The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study
Open accessAbstract
Background Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), with their findings inconsistent in terms of the anatomical locations and extent of abnormalities. This study examines white matter abnormalities in FESZ, compared with healthy controls, using a tract-based spatial statistics (TBSS) approach applied to multiple measures of tract integrity, and correlates these findings with symptom severity. Methods Seventeen first-episode patients with schizophrenia and seventeen age- and gender-matched healthy controls (HC) participated in this imaging study where FA, MD, and axial and radial diffusivities were compared between the two groups using TBSS. Results First-episode patients with schizophrenia showed lower FA values in the genu and body of corpus callosum, the internal capsule, the external capsule, the fornix, the superior, inferior fronto-occipital fasciculus, the cingulum, and the uncinate fasciculus compared with HC. Increased MD and radial diffusivity were shown in virtually all white matter regions. There was no significant difference, however, observed for axial diffusivity between the two groups. Pearson correlation analysis showed that the FA values of the right inferior fronto-occipital fasciculus were positively correlated with positive symptoms, negative symptoms, and total correct items of the Wisconsin Card Sorting Test. FA values of right external capsule also showed significant positive correlation with category completed scores of the WCST. Conclusions These data suggest extensive, possibly myelin related white matter disruptions in FESZ.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Lee et al. (2013) reported reduced FA in both the left and right cingulum of 17 first episode patients.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Lee et al. (2013)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen‐Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,598
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Self-citationChlorpromazine Equivalent Doses for the Newer Atypical Antipsychotics
Woods, S. W. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0607 · Cited by 2,056
Reproducibility of quantitative tractography methods applied to cerebral white matter
Wakana, S., Caprihan, A., Panzenboeck, M. M., Fallon, J. H., Perry, M., Gollub, R. L., Hua, K., Zhang, J., Jiang, H., Dubey, P., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.049 · Cited by 1,686
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658
Virtual in vivo interactive dissection of white matter fasciculi in the human brain
Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002) · NeuroImage · doi:10.1006/nimg.2002.1136 · Cited by 1,637
Hua, K., Zhang, J., Wakana, S., Jiang, H., Li, X., Reich, D. S., Calabresi, P. A., Pekar, J. J., van Zijl, P. C. M., & Mori, S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.053 · Cited by 1,507
Diffusion‐tensor MRI: theory, experimental design and data analysis – a technical review
Basser, P. J., & Jones, D. K. (2002) · NMR in Biomedicine · doi:10.1002/nbm.783 · Cited by 1,484
Cited by
Sorted by citations
The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740
Millan, M. J., Fone, K. C. F., Steckler, T., & Horan, W. P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.008 · Cited by 376
Herbet, G., Zemmoura, I., & Duffau, H. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00077 · Cited by 296
A review of structural neuroimaging in schizophrenia: from connectivity to connectomics
Wheeler, A. L., & Voineskos, A. N. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00653 · Cited by 266
Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy
Bernstein, H., Steiner, J. H., Guest, P. C., Dobrowolny, H., & Bogerts, B. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.035 · Cited by 203
Metadata
- Authors
- Lee, S.-H., Kubicki, M., Asami, T., Seidman, L. J., Goldstein, J. M., Mesholam-Gately, R. I., McCarley, R. W., & Shenton, M. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Corresponding author
- Lee, Sang-Hyuk
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 143
- Issue
- 2-3
- Pages
- 231-238
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC4354799
- OpenAlex
- W1965339644
- Cited by
- 176
- References
- 60
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 14 · 2020: 15 · 2019: 13 · 2018: 15 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 24 · 2013: 6
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Brigham and Women's Hospital (UL1RR025758)
- Massachusetts General Hospital
- Harvard University (UL1RR025758)
- National Institutes of Health
- National Institute of Mental Health (MH-50747, P50MH080272, MH40799, R01MH040799)
- National Center for Research Resources (M01-RR-01032, M01RR001032, UL1RR025758)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- first-episode schizophrenia, white matter abnormalities
- MeSH terms
- Adolescent, Adult, Brain, Female, Humans, Male, Schizophrenia, Severity of Illness Index, Young Adult, Diffusion Tensor Imaging, Leukoencephalopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
