Cited by 176Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

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Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study

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Lee, Sang-Hyuk, Kubicki, Marek, Asami, Takeshi, Seidman, Larry J., Goldstein, Jill M., Mesholam-Gately, Raquelle I., McCarley, Robert W., Shenton, Martha E.·2013·Schizophrenia Research

DOI 10.1016/j.schres.2012.11.029PMC PMC4354799

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Abstract

Background Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), with their findings inconsistent in terms of the anatomical locations and extent of abnormalities. This study examines white matter abnormalities in FESZ, compared with healthy controls, using a tract-based spatial statistics (TBSS) approach applied to multiple measures of tract integrity, and correlates these findings with symptom severity. Methods Seventeen first-episode patients with schizophrenia and seventeen age- and gender-matched healthy controls (HC) participated in this imaging study where FA, MD, and axial and radial diffusivities were compared between the two groups using TBSS. Results First-episode patients with schizophrenia showed lower FA values in the genu and body of corpus callosum, the internal capsule, the external capsule, the fornix, the superior, inferior fronto-occipital fasciculus, the cingulum, and the uncinate fasciculus compared with HC. Increased MD and radial diffusivity were shown in virtually all white matter regions. There was no significant difference, however, observed for axial diffusivity between the two groups. Pearson correlation analysis showed that the FA values of the right inferior fronto-occipital fasciculus were positively correlated with positive symptoms, negative symptoms, and total correct items of the Wisconsin Card Sorting Test. FA values of right external capsule also showed significant positive correlation with category completed scores of the WCST. Conclusions These data suggest extensive, possibly myelin related white matter disruptions in FESZ.

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Authors: Lee, S.-H., Kubicki, M., Asami, T., Seidman, L. J., Goldstein, J. M., Mesholam-Gately, R. I., McCarley, R. W., & Shenton, M. E.
Affiliations: Brigham and Women's Hospital (US)
Beth Israel Deaconess Medical Center (US)
Harvard University (US)
Corresponding author: Lee, Sang-Hyuk
ORCID: Lee, Sang-Hyuk
Kubicki, Marek
Asami, Takeshi
Seidman, Larry J.
Goldstein, Jill M.
McCarley, Robert W.
Shenton, Martha E.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2013-02
Volume: 143
Issue: 2-3
Pages: 231-238
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2012.11.029
PMC: PMC4354799
OpenAlex: W1965339644
Cited by: 176
References: 60
Citations by year: 2026: 2 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 14 · 2020: 15 · 2019: 13 · 2018: 15 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 24 · 2013: 6
FWCI: 17.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: Brigham and Women's Hospital (UL1RR025758)
Massachusetts General Hospital
Harvard University (UL1RR025758)
National Institutes of Health
National Institute of Mental Health (MH-50747, P50MH080272, MH40799, R01MH040799)
National Center for Research Resources (M01-RR-01032, M01RR001032, UL1RR025758)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: first-episode schizophrenia, white matter abnormalities
MeSH terms: Adolescent, Adult, Brain, Female, Humans, Male, Schizophrenia, Severity of Illness Index, Young Adult, Diffusion Tensor Imaging, Leukoencephalopathies

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Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study

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