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Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study
Open accessAbstract
Background Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), with their findings inconsistent in terms of the anatomical locations and extent of abnormalities. This study examines white matter abnormalities in FESZ, compared with healthy controls, using a tract-based spatial statistics (TBSS) approach applied to multiple measures of tract integrity, and correlates these findings with symptom severity. Methods Seventeen first-episode patients with schizophrenia and seventeen age- and gender-matched healthy controls (HC) participated in this imaging study where FA, MD, and axial and radial diffusivities were compared between the two groups using TBSS. Results First-episode patients with schizophrenia showed lower FA values in the genu and body of corpus callosum, the internal capsule, the external capsule, the fornix, the superior, inferior fronto-occipital fasciculus, the cingulum, and the uncinate fasciculus compared with HC. Increased MD and radial diffusivity were shown in virtually all white matter regions. There was no significant difference, however, observed for axial diffusivity between the two groups. Pearson correlation analysis showed that the FA values of the right inferior fronto-occipital fasciculus were positively correlated with positive symptoms, negative symptoms, and total correct items of the Wisconsin Card Sorting Test. FA values of right external capsule also showed significant positive correlation with category completed scores of the WCST. Conclusions These data suggest extensive, possibly myelin related white matter disruptions in FESZ.
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“Lee et al. (2013) reported reduced FA in both the left and right cingulum of 17 first episode patients.”
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Metadata
- Authors
- Lee, S.-H., Kubicki, M., Asami, T., Seidman, L. J., Goldstein, J. M., Mesholam-Gately, R. I., McCarley, R. W., & Shenton, M. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Corresponding author
- Lee, Sang-Hyuk
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 143
- Issue
- 2-3
- Pages
- 231-238
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC4354799
- OpenAlex
- W1965339644
- Cited by
- 176
- References
- 60
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 14 · 2020: 15 · 2019: 13 · 2018: 15 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 24 · 2013: 6
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Brigham and Women's Hospital (UL1RR025758)
- Massachusetts General Hospital
- Harvard University (UL1RR025758)
- National Institutes of Health
- National Institute of Mental Health (MH-50747, P50MH080272, MH40799, R01MH040799)
- National Center for Research Resources (M01-RR-01032, M01RR001032, UL1RR025758)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- first-episode schizophrenia, white matter abnormalities
- MeSH terms
- Adolescent, Adult, Brain, Female, Humans, Male, Schizophrenia, Severity of Illness Index, Young Adult, Diffusion Tensor Imaging, Leukoencephalopathies
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