Evidence for dysregulated high-frequency oscillations during sensory processing in medication-naïve, first episode schizophrenia
Abstract
Introduction High-frequency oscillations are important for sensory processing and dysfunctions in the amplitude and synchrony of beta- and gamma-band oscillations have been demonstrated in schizophrenia (ScZ). However, the presence of aberrant high-frequency oscillations in first-episode (FE), medication-naive patients during sensory processing is unclear. Methods Magnetoencephalographic (MEG) data were recorded from 15 never-medicated, FE-ScZ patients and 20 matched healthy controls during the perception of Mooney faces. MEG data were analysed for spectral power and single-sensor phase-locking in the beta (13-25Hz) and gamma- (25-140Hz) frequency range. Results FE-ScZ patients were characterized by significantly impaired sensory processing as indicated by a reduced discrimination index (A'). Impaired behavioural performance in ScZ-patients was accompanied by decreased spectral power in the high- (60-120Hz) gamma-band range. In contrast, oscillations in the lower (25-60Hz) gamma-band were largely intact and beta-band oscillations were increased. Analysis of cross-frequency coupling showed a reduced correlation between 60 and 120Hz amplitude values and beta-band power in FE-ScZ-patients relative to controls. Discussion Our findings show that impaired sensory processing in medication-naive, FE-schizophrenia is related to a dysregulation of neural oscillations which involves both an impairment in the generation of high gamma-band activity as well as a failure to downregulate tas…
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Deficits in gamma oscillations have been reported in first episode schizophrenia patients.
“deficits in gamma oscillations (a type of fast oscillatory activity that requires the function of PV+ fast spiking interneurons) has been reported in first episode schizophrenia patients 69,70 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [70]
Patients with established schizophrenia show reduced ability to spontaneously disambiguate two-tone images of faces without prior knowledge.
“it contrasts with previous studies in patients with established schizophrenia who show reduced ability to spontaneously disambiguate two-tone images of faces without prior knowledge (46,47).”
From Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals (2015) · cites this paper as [47]
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- Authors
- Sun, L., Castellanos, N., Grützner, C., Koethe, D., Rivolta, D., Wibral, M., Kranaster, L., Singer, W., Leweke, M. F., & Uhlhaas, P. J.
- Affiliations
- Harvard University (US)
- Universidad Politécnica de Madrid (ES)
- Max Planck Institute for Brain Research (DE)
- Heidelberg University (DE)
- Max Planck Society (DE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Uhlhaas, Peter J.
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 150
- Issue
- 2-3
- Pages
- 519-525
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W1972892012
- Cited by
- 96
- References
- 12
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 7
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, first-episode schizophrenia
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Cortical Synchronization, Electroencephalography, Female, Fourier Analysis, Humans, Male, Pattern Recognition, Visual, Perceptual Disorders, Photic Stimulation, Schizophrenia, Magnetoencephalography, Case-Control Studies, Young Adult
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