Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia
Open accessAbstract
BACKGROUND: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both to their proposed involvement in neuronal synchronization and to their association with neurotransmitter systems relevant for schizophrenia. Several task-related studies have confirmed reduced power and synchronization of gamma-band oscillations in schizophrenia, but it has been suggested that these findings might not apply to the resting state. The present study aimed to investigate resting-state gamma-band connectivity in patients with schizophrenia. METHODS: Sixty-four channel resting-state electroencephalography (eyes closed) was recorded in 22 patients with first-episode schizophrenia and 22 healthy controls matched for age and gender. Orthogonalized power envelope correlation was used as a measure of connectivity across 80 cortical regions at 40 Hz. Mean connectivity at each region was compared across groups using the nonparametric randomization approach. Additionally, the network-based statistic was applied to identify affected networks in patients. RESULTS: Patients displayed increased mean functional gamma-band connectivity compared to controls in the left rolandic operculum. Network-based analyses indicated increased connectivity in patients within a strongly lateralized network consisting mainly of left inferior frontal/orbitofrontal, lateral and medial temporal, and inferior parietal areas. Within this network, gamma-band connectivity was higher in patients with low positive and disorganization symptom levels. CONCLUSIONS: The present study provides a link between resting-state gamma-band connectivity and the core symptoms of schizophrenia. The observed findings are different than those reported by task-related studies, suggesting that resting-state studies might reveal new aspects in the pathophysiology of schizophrenia.
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Deficits in gamma oscillations have been reported in first episode schizophrenia patients.
“deficits in gamma oscillations (a type of fast oscillatory activity that requires the function of PV+ fast spiking interneurons) has been reported in first episode schizophrenia patients 69,70 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [69]
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- Authors
- Andreou, C., Nolte, G., Leicht, G., Polomac, N., Hanganu-Opatz, I. L., Lambert, M., Engel, A. K., & Mulert, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Andreou, Christina
- ORCID
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-08-28
- Volume
- 41
- Issue
- 4
- Pages
- 930-939
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC4466170
- OpenAlex
- W2028800859
- Cited by
- 129
- References
- 94
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 7 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 17 · 2019: 10 · 2018: 15 · 2017: 11 · 2016: 14 · 2015: 12 · 2014: 5
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- schizophrenia, first-episode schizophrenia
- MeSH terms
- Adult, Cerebral Cortex, Electroencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Schizophrenia, Young Adult, Connectome, Gamma Rhythm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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