Neuroanatomical correlates of perceptual aberrations in psychosis
Abstract
Background Aberrations in body perception are common in psychotic disorders. The insula and temporoparietal junction (TPJ) are involved in body ownership and spatial perception suggesting that abnormal structure of these regions might be related to the expression of perceptual aberrations in psychosis. Methods 58 individuals with a primary psychotic disorder and 40 healthy subjects completed the Chapman Perceptual Aberration Scale (PAS) and underwent structural magnetic resonance imaging (MRI). Grey matter volume was extracted from a-priori defined TPJ, whole insula, and insula sub-division regions-of-interest (ROIs) and correlated with PAS scores. Additionally, a voxel-based morphometry (VBM) analysis examining the correlation between voxel-wise grey matter volume and PAS scores was conducted. Results PAS scores in psychosis patients correlated with bilateral whole insula (right: r=-0.30, p=0.026; left: r=-0.35, p=0.011) and right TPJ (r=-0.27, p=0.024) volumes. The correlation between grey matter volume and PAS was strongest for the posterior sub-division of the insula (right: r=-0.32, p=0.017; left: r=-0.37, p=0.006). VBM analyses confirmed the ROI results: negative correlations with PAS were identified in clusters within the posterior and dorsal anterior insula, and the right TPJ. An exploratory, whole-brain analysis also revealed two additional regions located in the left middle orbitofrontal gyrus and left inferior temporal gyrus that inversely correlated with PAS score…
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Interoceptive abnormalities are noted in psychoses, obsessive-compulsive disorders and eating disorders.
“Interoceptive abnormalities are noted in psychoses (Brosey and Woodward, 2017), obsessive-compulsive disorders (Yoris et al., 2017) and eating disorders (Jenkinson et al., 2018).”
From Physiological feelings (2019) · cites this paper as Brosey and Woodward, 2017
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Pace-Schott, E. F., Amole, M. C., Aue, T., Balconi, M., Bylsma, L. M., Critchley, H., Demaree, H. A., Friedman, B. H., Gooding, A. E. K., Gosseries, O., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.002 · Cited by 221 · see citing works
“Interoceptive abnormalities are noted in psychoses (Brosey and Woodward, 2017), obsessive–compulsive disorders (Yoris et al.”
- Authors
- Brosey, E. A., & Woodward, N. D.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Woodward, Neil D.
- ORCID
- Woodward, Neil D.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 179
- Pages
- 125-131
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2530695124
- Cited by
- 12
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-07-01)
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- psychosis, perceptual aberration
- MeSH terms
- Adolescent, Adult, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Perceptual Disorders, Psychotic Disorders, Schizophrenia, Young Adult
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