Large-scale automated synthesis of human functional neuroimaging data.
Open accessAbstract
The rapid growth of the literature on neuroimaging in humans has led to major advances in our understanding of human brain function but has also made it increasingly difficult to aggregate and synthesize neuroimaging findings. Here we describe and validate an automated brain-mapping framework that uses text-mining, meta-analysis and machine-learning techniques to generate a large database of mappings between neural and cognitive states. We show that our approach can be used to automatically conduct large-scale, high-quality neuroimaging meta-analyses, address long-standing inferential problems in the neuroimaging literature and support accurate 'decoding' of broad cognitive states from brain activity in both entire studies and individual human subjects. Collectively, our results have validated a powerful and generative framework for synthesizing human neuroimaging data on an unprecedented scale.
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Claims the paper makes
19 of 35 cited sources checked · 13 supported · 0 flagged · accuracy not yet measured
- Premisecitation
Previous neuroimaging synthesis approaches relied heavily on researchers' manual efforts.
“previous approaches have relied heavily on researchers’ manual efforts (e.g., 7,8)”
Quote in the paperSubstantial claim2 of 2 sources checked - Findingown data
NeuroSynth replicated previous findings of visual category-specific activation in the fusiform face area and visual word form area.
“we used NeuroSynth to replicate previous findings of visual category-specific activation in regions such as the fusiform face area (FFA12) and visual word form area (VWFA13”
Quote in the paperSubstantial claim2 of 2 sources checked- cites [12] Kanwisher, N., McDermott, J. & Chun, M.M. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J. Neurosci. 17, 4302–4311 (1997). source
- cites [13] McCandliss, B.D., Cohen, L. & Dehaene, S. The visual word form area: expertise for reading in the fusiform gyrus. Trends Cogn. Sci. 7, 293–299 (2003). source
- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
- Findingown data
Automated meta-analyses of working memory, emotion, and pain converge markedly with previously published meta- or mega-analytic maps, both qualitatively and quantitatively.
“Comparison of automated meta-analyses of three broad psychological terms (‘working memory’, ‘emotion’, and ‘pain’) with previously published meta- or mega-analytic maps14-16 revealed a marked convergence between approaches both qualitatively (Fig. 2) and quantitatively (Supplementary Fig. 5).”
Quote in the paperSubstantial claim2 of 3 sources checked- cites [14] Atlas, L.Y., Bolger, N., Lindquist, M.A. & Wager, T.D. Brain mediators of predictive cue effects on perceived pain. J. Neurosci. 30, 12964–12977 (2010). source
- cites [15] Wager, T.D., Lindquist, M.A., Nichols, T.E., Kober, H. & Van Snellenberg, J.X. Evaluating the consistency and specificity of neuroimaging data using meta-analysis. Neuroimage 45, 210–221 (2009). source
- cites [16] Kober, H. et al. Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage 42, 998–1031 (2008). source
- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
- Interpretationreasoning
Distilling the extant literature necessitates new techniques for large-scale aggregation and synthesis of human neuroimaging data.
“Distilling the extant literature thus necessitates development of new techniques for large-scale aggregation and synthesis of human neuroimaging data4-6.”
Quote in the paperNot a substantial claim1 of 3 sources checked- cites [4] Yarkoni, T., Poldrack, R.A., Van Essen, D.C. & Wager, T.D. Cognitive neuroscience 2.0: building a cumulative science of human brain function. Trends Cogn. Sci. 14, 489–496 (2010). source
- cites [5] Van Horn, J.D., Grafton, S.T., Rockmore, D. & Gazzaniga, M.S. Sharing neuroimaging studies of human cognition. Nat. Neurosci. 7, 473–481 (2004). source
- cites [6] Fox, P.T., Parsons, L.M. & Lancaster, J.L. Beyond the single study: function/location metanalysis in cognitive neuroimaging. Curr. Opin. Neurobiol. 8, 178–187 (1998). source
- Findingown data
Automatically extracted coordinates compared with manually entered SumsDB foci had sensitivity of 84% and specificity of 97%.
“we compared automatically extracted coordinates with a reference set of manually-entered foci in the SumsDB database7,9, revealing high rates of sensitivity (84%) and specificity (97%).”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [7] Van Essen, D.C. Lost in localization—but found with foci?! Neuroimage 48, 14–17 (2009). source
- cites [9] Dickson, J., Drury, H.A. & Van Essen, D.C. “The surface management system” (SuMS) database: a surface-based database to aid cortical surface reconstruction, visualization and analysis. Phil. Trans. R. Soc. Lond. B 356, 1277–1292 (2001). source
- Findingown data
For working memory, the forward inference map revealed the most consistent associations in dorsolateral prefrontal cortex (DLPFC), anterior insula and dorsal medial frontal cortex (MFC).
“For working memory, the forward inference map revealed the most consistent associations in dorsolateral prefrontal cortex (DLPFC), anterior insula and dorsal medial frontal cortex (MFC), replicating previous findings15,20.”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [15] Wager, T.D., Lindquist, M.A., Nichols, T.E., Kober, H. & Van Snellenberg, J.X. Evaluating the consistency and specificity of neuroimaging data using meta-analysis. Neuroimage 45, 210–221 (2009). source
The Introduction’s discussion of functional specificity (page unavailable) reports consistent prefrontal activation when working memory is involved and consistent pre-supplementary motor activation across the task types examined. It does not identify DLPFC, anterior insula, and dorsal MFC together as the most consistent working-memory associations, so it supports only part of the claimed replication. (LLM, conf=0.80)
Experimental — accuracy not yet measured - cites [20] Owen, A.M., McMillan, K.M., Laird, A.R. & Bullmore, E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum. Brain Mapp. 25, 46–59 (2005). source
- Interpretationreasoning
The involvement of these frontal regions in pain and emotion likely reflected their much more general role in cognition rather than pain- or emotion-specific process.
“Thus, the fact that these regions showed involvement in pain and emotion likely reflected their much more general role in cognition (e.g., sustained attention or goal-directed processing22,23) rather than pain- or emotion-specific process.”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [22] Duncan, J. The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. Trends Cogn. Sci. 14, 172–179 (2010). source
- cites [23] Yarkoni, T., Barch, D.M., Gray, J.R., Conturo, T.E. & Braver, T.S. BOLD correlates of trial-by-trial reaction time variability in gray and white matter: a multi-study fMRI analysis. PLoS ONE 4, e4257 (2009). source
- Findingown data
NeuroSynth produced a database of term-to-coordinate mappings based on 100,953 activation foci drawn from 3,489 neuroimaging studies published in more than 15 journals.
“we report results based on 100,953 activation foci drawn from 3,489 neuroimaging studies published in more than 15 journals”
Quote in the paperSubstantial claim - Findingown data
The authors were able to quantify the probability of a term occurring in an article given the presence of activation in a particular brain region (P(Term|Activation), reverse inference).
“We were able to quantify both the probability of observing activation in specific brain regions given the presence a particular term (P(Activation|Term), or ‘forward inference’), and the probability of a term occurring in an article given the presence of activation in a particular brain region (i.e., P(Term|Activation), or reverse inference).”
Quote in the paperSubstantial claim - Findingown data
NeuroSynth accurately recaptured conventional boundaries between distinct anatomical regions when lexically defined ROIs were compared to anatomically defined ROIs.
“we demonstrated that NeuroSynth accurately recaptured conventional boundaries between distinct anatomical regions by comparing lexically defined regions-of-interest (ROIs) to anatomically defined ROIs”
Quote in the paperSubstantial claim- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
- Findingown data
Automated and manual analyses of pain studies showed a striking overlap, with a correlation across voxels of .84.
“Direct comparison between automated and manual results revealed a striking overlap (correlation across voxels = .84; Supplementary Fig. 6).”
Quote in the paperSubstantial claim- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
- Findingown data
Activation decreases have minimal effect on the results reported in the paper.
“have minimal effect on the results we report”
Quote in the paperNot a substantial claim - Findingown data
The authors were able to quantify the probability of observing activation in specific brain regions given the presence of a particular term (P(Activation|Term), forward inference).
“We were able to quantify both the probability of observing activation in specific brain regions given the presence a particular term (P(Activation|Term), or ‘forward inference’), and the probability of a term occurring in an article given the presence of activation in a particular brain region (i.e., P(Term|Activation), or reverse inference).”
Quote in the paperSubstantial claim - Findingown data
More conservative meta-analyses restricting the lexical search space to only article titles yielded similar, though less sensitive, meta-analysis results.
“more conservative meta-analyses restricting the lexical search space to only article titles yielded similar, though less sensitive, meta-analysis results”
Quote in the paperNot a substantial claim- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
- Findingown data
Automated coordinate extraction misses a minority of valid coordinates.
“automated extraction misses a minority of valid coordinates”
Quote in the paperSubstantial claim - Findingown data
Each of these domains (working memory, emotion, pain) has a relatively distinct neural signature.
“In a 10-fold cross-validated analysis, the classifier discriminated between studies of working memory, emotion, and pain, with high sensitivity and specificity (Fig. 4a), demonstrating that each of these domains has a relatively distinct neural signature (Fig. 4b).”
Quote in the paperSubstantial claim - Findingown data
Incorrectly classified subjects in physical pain tasks systematically activated lateral orbitofrontal cortex and dorsomedial prefrontal cortex, but not SII/posterior insula.
“For example, incorrectly classified subjects in physical pain tasks (e.g., Fig. 4c) systematically activated lateral orbitofrontal cortex and dorsomedial prefrontal cortex, but not SII/posterior insula, suggesting that the discomfort due to noxious heat in these subjects may have been qualitatively different (e.g., emotionally-generated vs. physically-generated pain).”
Quote in the paperSubstantial claim - Findingnone given
The automated tools are unable to extract information about fine-grained cognitive states, such as different negative emotions.
“they are unable to extract information about fine-grained cognitive states (e.g., different negative emotions)”
Quote in the paperSubstantial claim - Findingreasoning
Several frontal regions that showed consistent activation for emotion and pain in the forward analysis were associated with a decreased likelihood that a study involved emotion or pain in the reverse inference analysis.
“Perhaps most strikingly, several frontal regions that showed consistent activation for emotion and pain in the forward analysis were actually associated with a decreased likelihood that a study involved emotion or pain in the reverse inference analysis (Fig. 3).”
Quote in the paperSubstantial claim - Findingown data
In a 10-fold cross-validated analysis, the classifier discriminated between studies of working memory, emotion, and pain with high sensitivity and specificity.
“In a 10-fold cross-validated analysis, the classifier discriminated between studies of working memory, emotion, and pain, with high sensitivity and specificity (Fig. 4a), demonstrating that each of these domains has a relatively distinct neural signature (Fig. 4b).”
Quote in the paperSubstantial claim - Findingown data
A similar pattern was observed for pain and emotion.
“We observed a similar pattern for pain and emotion.”
Quote in the paperNot a substantial claim - Findingnone given
The automated tools accurately extract coordinates from articles.
“while our automated tools accurately extract coordinates from articles”
Quote in the paperNot a substantial claim - Findingown data
Pain was highly discriminable from other psychological concepts (all pairwise accuracies > 74%).
“For instance, pain was highly discriminable from other psychological concepts (all pairwise accuracies > 74%), suggesting that pain perception may be a distinctive state that is neither grouped with other sensory modalities or with other affective concepts like arousal and emotion.”
Quote in the paperSubstantial claim - Findingown data
For pain, the regions of maximal pain-related activation in insula and ACC shifted from anterior foci in the forward analysis to posterior ones in the reverse analysis.
“For pain, the regions of maximal pain-related activation in insula and ACC shifted from anterior foci in the forward analysis to posterior ones in the reverse analysis (Fig. 3).”
Quote in the paperSubstantial claim - Findingown data
Results revealed important differences between the forward and reverse inference maps in all three domains (working memory, emotion, pain).
“Results revealed important differences between the forward and reverse inference maps in all three domains (Fig. 2).”
Quote in the paperSubstantial claim - Findingown data
For working memory, the reverse inference map implicated anterior PFC and posterior parietal cortex as the regions most selectively activated by working memory tasks.
“However, the reverse inference map instead implicated anterior PFC and posterior parietal cortex as the regions most selectively activated by working memory tasks.”
Quote in the paperSubstantial claim - Findingown data
The authors demonstrated the viability of decoding broad psychological states in a relatively open-ended way in individual subjects.
“Second, we demonstrated the viability of decoding broad psychological states in a relatively open-ended way in individual subjects—to our knowledge, the first application of a domain-general classifier that can distinguish a broad range of cognitive states based solely on prior literature.”
Quote in the paperSubstantial claim - Findingreasoning
Conceptually related terms like 'executive' and 'working memory' could not be distinguished at a rate different from chance.
“Conversely, conceptually related terms like ‘executive’ and ‘working memory’ could not be distinguished at a rate different from chance, reflecting their closely overlapping usage in the literature.”
Quote in the paperNot a substantial claim - Findingown data
For emotion, the reverse inference map revealed much more selective activations in the amygdala and ventromedial PFC.
“For emotion, the reverse inference map revealed much more selective activations in the amygdala and ventromedial PFC (Fig. 3).”
Quote in the paperSubstantial claim - Findingown data
There were systematic differences in activation patterns for correctly vs. incorrectly classified subjects.
“Moreover, there were systematic differences in activation patterns for correctly vs. incorrectly classified subjects.”
Quote in the paperNot a substantial claim - Interpretationcitation
Reliance on manual efforts limits the scope and efficiency of resulting analyses.
“a constraint that limits the scope and efficiency of resulting analyses1”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [1] Derrfuss, J. & Mar, R.A. Lost in localization: the need for a universal coordinate database. Neuroimage 48, 1–7 (2009). source
- Interpretationown data
The majority of automatically extracted coordinates are extracted accurately.
“the majority of coordinates are extracted accurately”
Quote in the paperSubstantial claim - Premisecitation
Most neuroimaging studies are designed to identify neural changes resulting from known psychological manipulations, not to determine what cognitive state(s) a given pattern of activity implies.
“most neuroimaging studies are designed to identify neural changes that result from known psychological manipulations, and not to determine what cognitive state(s) a given pattern of activity implies”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Poldrack, R.A. Can cognitive processes be inferred from neuroimaging data? Trends Cogn. Sci. 10, 59–63 (2006). source
- Interpretationreasoning
The NeuroSynth framework is well suited for drawing quantitative inferences about mind-brain relationships in both the forward and reverse directions.
“Because the NeuroSynth database contains a broad set of term-to-activation mappings, our framework is well suited for drawing quantitative inferences about mind-brain relationships in both the forward and reverse directions.”
Quote in the paperSubstantial claim - Interpretationreasoning
Multiple studies are required to achieve consensus regarding even broad relationships between brain and cognitive function.
“multiple studies are required to achieve consensus regarding even broad relationships between brain and cognitive function.”
Quote in the paperSubstantial claim - Interpretationreasoning
Comparison of forward and reverse inference analyses provided a way to assess the validity of many common inferences about the relationship between neural and cognitive states.
“Comparison of these two analyses provided a way to assess the validity of many common inferences about the relationship between neural and cognitive states.”
Quote in the paperSubstantial claim - Interpretationown data
At least for broad domains, an automated meta-analysis approach generates results comparable in sensitivity and scope to those produced more effortfully in previous studies.
“Thus, these results demonstrated that, at least for broad domains, an automated meta-analysis approach generates results comparable in sensitivity and scope to those produced more effortfully in previous studies.”
Quote in the paperSubstantial claim- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
- Interpretationown data
A number of factors of a priori concern have relatively small influences on the results.
“a number of factors of a priori concern have relatively small influences on the results.”
Quote in the paperSubstantial claim - Interpretationown data
The inability to distinguish executive and working memory reflects their closely overlapping usage in the literature.
“Conversely, conceptually related terms like ‘executive’ and ‘working memory’ could not be distinguished at a rate different from chance, reflecting their closely overlapping usage in the literature.”
Quote in the paperSubstantial claim - Interpretationreasoning
The present NeuroSynth implementation provides no basis for inferences about more nuanced cognitive and affective states, as it distinguishes only between relatively broad psychological categories.
“However, the present NeuroSynth implementation provides no basis for such inferences, as it distinguishes only between relatively broad psychological categories.”
Quote in the paperSubstantial claim - Interpretationreasoning
Neglecting the high base rate of ACC activity might lead researchers in cognitive control, pain, and emotion to each conclude that the ACC plays a critical role in their particular domain.
“For instance, neglecting the high base rate of ACC activity might lead researchers in the areas of cognitive control, pain, and emotion each to conclude that the ACC plays a critical role in their particular domain.”
Quote in the paperSubstantial claim - Interpretationreasoning
A key benefit of the framework is the ability to quantitatively distinguish forward inference from reverse inference, enabling researchers to assess the specificity of mappings between neural and cognitive function.
“A key benefit is the ability to quantitatively distinguish forward inference from reverse inference, enabling researchers to assess the specificity of mappings between neural and cognitive function—a long-standing goal of cognitive neuroscience research.”
Quote in the paperSubstantial claim - Interpretationown data
These findings demonstrate the viability of decoding cognitive states in new subjects without training.
“Thus, these findings demonstrate the viability of decoding cognitive states in new subjects without training while suggesting novel hypotheses amenable to further exploration.”
Quote in the paperSubstantial claim - Interpretationown data
The results provide insights into the similarity structure of neural representation for different processes.
“Moreover, the results provide insights into the similarity structure of neural representation for different processes.”
Quote in the paperSubstantial claim - Interpretationreasoning
The ability to decode brain activity without prior training data or knowledge of the "ground truth" for an individual is particularly promising.
“Particularly promising is the ability to decode brain activity without prior training data or knowledge of the “ground truth” for an individual.”
Quote in the paperSubstantial claim - Interpretationown data
This is the first application of a domain-general classifier that can distinguish a broad range of cognitive states based solely on prior literature.
“Second, we demonstrated the viability of decoding broad psychological states in a relatively open-ended way in individual subjects—to our knowledge, the first application of a domain-general classifier that can distinguish a broad range of cognitive states based solely on prior literature.”
Quote in the paperSubstantial claim - Interpretationreasoning
The Neurosynth framework is currently useful primarily for large-scale analyses involving broad domains.
“Thus, the Neurosynth framework is currently useful primarily for large-scale analyses involving broad domains”
Quote in the paperSubstantial claim - Interpretationown data
Pain perception may be a distinctive state that is neither grouped with other sensory modalities nor with other affective concepts like arousal and emotion.
“For instance, pain was highly discriminable from other psychological concepts (all pairwise accuracies > 74%), suggesting that pain perception may be a distinctive state that is neither grouped with other sensory modalities or with other affective concepts like arousal and emotion.”
Quote in the paperSubstantial claim - Study design and conductnone given
The authors validated a novel approach for conducting large-scale automated neuroimaging meta-analyses of broad psychological concepts that are lexically well represented in the literature.
“First, we validated a novel approach for conducting large-scale automated neuroimaging meta-analyses of broad psychological concepts that are lexically well represented in the literature.”
Quote in the paperSubstantial claim - Interpretationreasoning
The NeuroSynth framework can potentially address this problem by enabling researchers to conduct quantitative reverse inference on a large scale.
“The NeuroSynth framework can potentially address this problem by enabling researchers to conduct quantitative reverse inference on a large scale.”
Quote in the paperSubstantial claim - Interpretationreasoning
Without the ability to distinguish consistency from selectivity, neuroimaging data can produce misleading inferences.
“These results demonstrate that without the ability to distinguish consistency from selectivity, neuroimaging data can produce misleading inferences.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 12
- May combine two claims. 12
- Not yet classified. 1
Classified as probably not a substantial claim.
PremisecitationTrue reverse inference requires knowledge of which brain regions and networks are selectively, and not just consistently, associated with particular cognitive states.
“True reverse inference requires knowledge of which brain regions and networks are selectively, and not just consistently, associated with particular cognitive states15,17.”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [15] Wager, T.D., Lindquist, M.A., Nichols, T.E., Kober, H. & Van Snellenberg, J.X. Evaluating the consistency and specificity of neuroimaging data using meta-analysis. Neuroimage 45, 210–221 (2009). source
- cites [17] Poldrack, R.A. Can cognitive processes be inferred from neuroimaging data? Trends Cogn. Sci. 10, 59–63 (2006). source
May combine two claims.
InterpretationcitationWorking memory, emotion, and pain are excellent candidates for quantitative reverse inference.
“These domains are excellent candidates for quantitative reverse inference, as they are thought to have somewhat confusable neural correlates, with common activation of regions such as dorsal anterior cingulate cortex (ACC)19 and anterior insula.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [19] Shackman, A.J. et al. The integration of negative affect, pain and cognitive control in the cingulate cortex. Nat. Rev. Neurosci. 12, 154–167 (2011). source
The ‘Functional imaging evidence of overlap in aMCC’ section reports overlapping dorsal cingulate activation for negative affect, pain, and cognitive control, supporting the rationale for comparing their neural correlates. Its cognitive-control analysis used tasks such as Stroop and Go/No-Go, not working-memory tasks, so the source does not establish the claimed overlap for working memory specifically. The judgment that these are ‘excellent candidates’ for reverse inference is the citing authors’ framing, not a finding attributed to this source. (LLM, conf=0.84)
Experimental — accuracy not yet measured
- Rests on an assumption: Working memory, emotion, and pain are of substantial basic and clinical interest and have been extensively studied using fMRI.
Classified as probably not a substantial claim. May combine two claims.
PremisecitationWorking memory, emotion, and pain are thought to have somewhat confusable neural correlates, with common activation of regions such as dorsal anterior cingulate cortex (ACC) and anterior insula.
“These domains are excellent candidates for quantitative reverse inference, as they are thought to have somewhat confusable neural correlates, with common activation of regions such as dorsal anterior cingulate cortex (ACC)19 and anterior insula.”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [19] Shackman, A.J. et al. The integration of negative affect, pain and cognitive control in the cingulate cortex. Nat. Rev. Neurosci. 12, 154–167 (2011). source
The Functional imaging evidence of overlap in aMCC section reports common anterior midcingulate activation for negative affect, pain, and cognitive control, supporting the cited point about overlapping dorsal cingulate correlates. Its cognitive-control tasks are Stroop, Go/No-Go, and Flanker tasks; it does not establish the same overlap specifically for working memory. The citation is attached to dorsal ACC, not anterior insula. (LLM, conf=0.83)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationIndividual neuroimaging studies are often underpowered and exhibit relatively high false positive rates.
“individual neuroimaging studies are often underpowered and exhibit relatively high false positive rate2-4”
Quote in the paperSubstantial claim2 of 3 sources checked- cites [2] Yarkoni, T. Big correlations in little studies: inflated fMRI correlations reflect low statistical power—commentary on Vul et al. (2009). Perspect. Psychol. Sci. 4, 294–298 (2009). source
- cites [3] Wager, T.D., Lindquist, M. & Kaplan, L. Meta-analysis of functional neuroimaging data: current and future directions. Soc. Cogn. Affect. Neurosci. 2, 150–158 (2007). source
The Introduction says small samples create pressure to maintain statistical power and that inadequately corrected thresholds are the rule; it estimates that about 17% of reported peaks in its sample are false positives. This supports the false-positive claim, but it does not establish that individual studies are often underpowered. (LLM, conf=0.82)
Experimental — accuracy not yet measured - cites [4] Yarkoni, T., Poldrack, R.A., Van Essen, D.C. & Wager, T.D. Cognitive neuroscience 2.0: building a cumulative science of human brain function. Trends Cogn. Sci. 14, 489–496 (2010). source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationFear consistently activates the human amygdala.
“fear consistently activates the human amygdala”
Quote in the paperNot a substantial claim1 of 2 sources checked- cites [4] Yarkoni, T., Poldrack, R.A., Van Essen, D.C. & Wager, T.D. Cognitive neuroscience 2.0: building a cumulative science of human brain function. Trends Cogn. Sci. 14, 489–496 (2010). source
In ‘Most neuroimaging studies are underpowered’ (page unavailable), the paper discusses amygdala activation for fear, but says meta-analytic evidence finds it at least as activated for disgust. That supports an association with fear, not the stronger claim that fear consistently activates the amygdala. The paper’s rejection of fear specificity does not itself contradict the claim. (LLM, conf=0.77)
Experimental — accuracy not yet measured - cites [18] Zald, D.H. The human amygdala and the emotional evaluation of sensory stimuli. Brain Res. Brain Res. Rev. 41, 88–123 (2003). source
May combine two claims.
InterpretationcitationAmygdala activation does not imply that a person is experiencing fear, because other affective and non-affective states have also been reported to produce amygdala activation.
“this does not imply that people who show amygdala activation must be experiencing fear, because other affective and non-affective states have also been reported to produce amygdala activation4,18.”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [4] Yarkoni, T., Poldrack, R.A., Van Essen, D.C. & Wager, T.D. Cognitive neuroscience 2.0: building a cumulative science of human brain function. Trends Cogn. Sci. 14, 489–496 (2010). source
In 'Selective association is difficult to establish' (page unavailable), the paper rejects the idea that increased amygdala activity is a specific marker of fear. In 'Most neuroimaging studies are underpowered' (page unavailable), it reports that disgust activates the amygdala at least as much as fear. These passages support the inference about fear and another affective state, but do not report amygdala activation in non-affective states. (LLM, conf=0.85)
Experimental — accuracy not yet measured - cites [18] Zald, D.H. The human amygdala and the emotional evaluation of sensory stimuli. Brain Res. Brain Res. Rev. 41, 88–123 (2003). source
May combine two claims.
Findingown dataIn pain and emotion, frontal regions broadly implicated in goal-directed cognition showed consistent activation in the forward analysis but were relatively non-selective in the reverse analysis.
“In both domains, frontal regions broadly implicated in goal-directed cognition21-23 showed consistent activation in the forward analysis, but were relatively non-selective in the reverse analysis (Fig. 2).”
Quote in the paperSubstantial claim1 of 3 sources checked- cites [21] Dosenbach, N.U. et al. A core system for the implementation of task sets. Neuron 50, 799–812 (2006). source
- cites [22] Duncan, J. The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. Trends Cogn. Sci. 14, 172–179 (2010). source
- cites [23] Yarkoni, T., Barch, D.M., Gray, J.R., Conturo, T.E. & Braver, T.S. BOLD correlates of trial-by-trial reaction time variability in gray and white matter: a multi-study fMRI analysis. PLoS ONE 4, e4257 (2009). source
May combine two claims.
InterpretationcitationThe shift in pain-related activation from anterior to posterior insula/ACC is consistent with nonhuman primate studies implicating dorsal posterior insula as a primary integration center for nociceptive afferents and human studies demonstrating that anterior aspects of the so-called 'pain matrix' respond non-selectively to multiple modalities.
“This is consistent with nonhuman primate studies implicating dorsal posterior insula as a primary integration center for nociceptive afferents24 as well as human studies demonstrating that anterior aspects of the so-called ‘pain matrix’ respond non-selectively to multiple modalities25.”
Quote in the paperSubstantial claim1 of 2 sources checked- cites [24] Craig, A.D. How do you feel? Interoception: the sense of the physiological condition of the body. Nat. Rev. Neurosci. 3, 655–666 (2002). source
- cites [25] Legrain, V., Iannetti, G.D., Plaghki, L. & Mouraux, A. The pain matrix reloaded: a salience detection system for the body. Prog. Neurobiol. 93, 111–124 (2011). source
Not yet classified.
FindingActivation decreases constitute a small proportion of results reported in the neuroimaging literature.
“decreases constitute a small proportion of results”
Quote in the paperNot yet classifiedClassified as probably not a substantial claim.
Findingnone givenThe NeuroSynth database contains a broad set of term-to-activation mappings.
“Because the NeuroSynth database contains a broad set of term-to-activation mappings, our framework is well suited for drawing quantitative inferences about mind-brain relationships in both the forward and reverse directions.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe seeming paradox reflected that lateral and medial frontal regions were consistently activated in studies of emotion and pain, but were activated even more frequently in studies that did not involve emotion or pain.
“This seeming paradox reflected the fact that even though lateral and medial frontal regions were consistently activated in studies of emotion and pain, they were activated even more frequently in studies that did not involve emotion or pain (Supplementary Fig. 8).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe classifier performed substantially above chance, identifying the originating study type with sensitivities of 94%, 70%, and 65%, respectively (chance = 33%), and specificities of 80%, 86%, and 98%.
“The classifier performed substantially above chance, identifying the originating study type with sensitivities of 94%, 70%, and 65%, respectively (chance = 33%), and specificities of 80%, 86%, and 98% (Fig. 4a).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe classifier performed substantially above chance in two-alternative classification (mean pairwise accuracy of 72%) and relatively open-ended multi-class classification on up to ten simultaneous terms.
“The classifier performed substantially above chance in both two-alternative classification (mean pairwise accuracy of 72%; Fig. 4) and relatively open-ended multi-class classification on up to ten simultaneous terms (Supplementary Fig. 9).”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningThe NeuroSynth framework is fully automated, enabling rapid and scalable synthesis of the neuroimaging literature.
“the present framework is fully automated, enabling rapid and scalable synthesis of the neuroimaging literature.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductnone givenThe automated extraction software did not discriminate activations from deactivations.
“the software did not discriminate activations from deactivations.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationIn 2010, more than 1,000 fMRI articles were published.
“In 2010 alone, over 1,000 fMRI articles were published1.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [1] Derrfuss, J. & Mar, R.A. Lost in localization: the need for a universal coordinate database. Neuroimage 48, 1–7 (2009). source
May combine two claims.
Interpretationown dataNeuroSynth supports accurate decoding of broad cognitive states from brain activity in both entire studies and individual human subjects.
“support accurate ‘decoding’ of broad cognitive states from brain activity in both entire studies and individual human subjects.”
Quote in the paperSubstantial claim- The authors state this as an assumption: Simple word counts are a reasonable proxy for the substantive content of articles.
Classified as probably not a substantial claim.
InterpretationreasoningThe NeuroSynth framework introduced here addresses the problem of comprehensive synthesis of the literature in several ways.
“The NeuroSynth framework introduced here addresses this problem in several ways.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Interpretationnone givenThe platform introduced is designed to support immediate use in a broad range of neuroimaging applications.
“Third, the platform we introduce is designed to support immediate use in a broad range of neuroimaging applications.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningThe present reliance on a purely lexical coding approach is suboptimal because it relies on traditional psychological terms that may fail to carve the underlying neural substrates at their natural joints.
“the present reliance on a purely lexical coding approach, while effective, is suboptimal in that it relies on traditional psychological terms that may fail to carve the underlying neural substrates at their natural joints”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningThe lexical coding approach fails to capitalize on redundancy across terms, modeling closely overlapping terms such as 'pain', 'nociception', and 'noxious' separately.
“fails to capitalize on redundancy across terms (e.g., ‘pain’, ‘nociception’, and ‘noxious’ overlap closely but are modeled separately)”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningBecause the ACC is activated consistently in all of these states, its activation may not be diagnostic of any one of them and might even predict their absence.
“Instead, because the ACC is activated consistently in all of these states, its activation may not be diagnostic of any one of them—and conversely, might even predict their absence.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningThe discomfort due to noxious heat in incorrectly classified subjects may have been qualitatively different (e.g., emotionally-generated vs. physically-generated pain).
“For example, incorrectly classified subjects in physical pain tasks (e.g., Fig. 4c) systematically activated lateral orbitofrontal cortex and dorsomedial prefrontal cortex, but not SII/posterior insula, suggesting that the discomfort due to noxious heat in these subjects may have been qualitatively different (e.g., emotionally-generated vs. physically-generated pain).”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
InterpretationreasoningThe lexical coding approach does not allow closely related constructs, such as physical versus emotional pain, to be easily distinguished.
“does not allow closely related constructs to be easily distinguished (e.g., physical vs. emotional pain)”
Quote in the paperSubstantial claim
The authors state this as an assumption.
Simple word counts are a reasonable proxy for the substantive content of articles.
“which rests on the assumption that simple word counts are a reasonable proxy for the substantive content of articles”
The paper relies on this without support.
Working memory, emotion, and pain are of substantial basic and clinical interest and have been extensively studied using fMRI.
“For illustration purposes, we focused on the sample domains of working memory, emotion, and pain, which are of substantial basic and clinical interest and have been extensively studied using fMRI (for additional examples, see Supplementary Fig. 7).”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The aMCC is among the most frequently reported areas of activation in functional MRI research, with activations in pain, emotion, reward, conflict monitoring, error detection, memory, and social cognition.
“Indeed, meta-analyses indicate that it is among the most frequently reported areas of activation in functional MRI research (Clark-Polner et al., 2016; Nelson et al., 2010; Yarkoni et al., 2011), with reported activations in processes including pain, emotion, reward, conflict monitoring, error detection, memory, and social cognition (Beckmann et al., 2009; Wager et al., 2016).”
From Motivation in the Service of Allostasis: The Role of Anterior Mid-Cingulate Cortex (2019) · cites this paper as Yarkoni et al., 2011
In Results > Quantitative reverse inference (page unavailable), the paper describes a high base rate of ACC activity across studies, supporting the general point that cingulate activation is frequently reported. It does not establish that the aMCC specifically is among the most frequently reported areas. The list of processes is attached to different citations in the citing sentence, so it is not assessed against Yarkoni et al. (LLM, conf=0.82)
Experimental — accuracy not yet measuredNeuroSynth meta-analyses showed the medial temporal subsystem corresponded most strongly with past and future autobiographical thought, episodic memory, and contextual retrieval.
“The medial temporal subsystem corresponded most strongly with meta-analytic maps pertaining to past and future autobiographical thought (i.e., autobiographical, past, future), episodic memory (i.e., episodic, memories, remember, recollection, recall) and contextual retrieval (i.e., contextual, retrieval) (Fig. 4).”
From The default network and self-generated thought: component processes, dynamic control, and clinical relevance (2014) · cites this paper as [65]
NeuroSynth meta-analyses showed the dorsal medial subsystem corresponded most strongly with mentalizing and social cognition, as well as story comprehension and semantic or conceptual processing.
“Out of 526 meta-analyses in the NeuroSynth database, the dorsal medial subsystem corresponded most strongly with meta-analytic maps pertaining to mentalizing and social cognition (i.e., mentalizing, social, person, theory of mind, mental, scenarios), as well as story comprehension and semantic/conceptual processing (i.e., comprehension, semantic, sentence, story, meaning, knowledge, language, word”
From The default network and self-generated thought: component processes, dynamic control, and clinical relevance (2014) · cites this paper as [65]
Neurosynth analysis of the terms shifting, updating, and inhibition shows highly overlapping activation maps in lateral frontoparietal and midcingulo-insular regions.
“Entering the terms describing the latent variables comprising executive function into Neurosynth reveals that the brain maps associated with these interrelated cognitive constructs are highly overlapping7 (Fig. 1a).”
From Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations (2021) · cites this paper as [29]
A recent database of nearly 4,400 studies, Neurosynth, permits the construction of meta-analytic maps of consistent activations across studies based on terms frequently used in articles.
“A recent database of nearly 4,400 studies, called Neurosynth (www.neurosynth.org; [21]), permits the construction of meta-analytic maps of consistent activations across studies based on terms frequently used in articles.”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [21]
Entering the term "SN" in Neurosynth yields a set of cortical regions that overlaps very closely with the more anterior cingulo-insular network of Yeo et al. (2011).
“Entering the term “SN” yields a set of cortical regions that overlaps very closely with the more anterior cingulo-insular network of Yeo et al. (2011).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Yarkoni et al., 2011
The regions most strongly associated with pain affect (dACC and aINS) are the most frequently activated brain areas in fMRI studies across all task types.
“the regions most strongly associated with pain affect (the aversiveness of pain; i.e., dorsal anterior cingulate cortex [dACC] and anterior insula [aINS]) are the most frequently activated brain areas in fMRI studies across all task types [36].”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [36]
The correlation between the map of stimulus intensity effects and the self-regulation effects was r = 0.02 across all voxels, and r = −0.13 across voxels in the Neurosynth meta-analytic map for pain.
“The correlation between the map of stimulus intensity effects and the self-regulation effects was r = 0.02 across all voxels, and r = −0.13 across voxels in the Neurosynth meta-analytic map for “pain” [36].”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [36]
NeuroSynth allows for reverse inference of cognitive states based on a given brain gene expression map with high specificity.
“By collecting data from more than 14,000 fMRI studies, NeuroSynth27 allows for reverse inference of cognitive states based on a given brain gene expression map with high specificity.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [27]
Commonly observed increases in medial and lateral frontal region activity during emotion and pain processing seem to be better explained by more general sustained attention processes.
“For instance, commonly observed increases in medial and lateral frontal region activity during emotion and pain processing seem to be better explained by more general sustained attention processes27.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [27]
The NeuroSynth framework has extracted text and neuroimaging data from 14,371 fMRI studies (release 0.7).
“The NeuroSynth framework27 has extracted text and neuroimaging data from 14,371 fMRI studies (release 0.7).”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [27]
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Self-citationFunctional Magnetic Resonance Imaging (fMRI)
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Lost in localization — But found with foci?!
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Self-citationPrecision Functional Mapping of Individual Human Brains
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The evolution of distributed association networks in the human brain
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Chang, L. J., Yarkoni, T., Khaw, M. W., & Sanfey, A. G. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs065 · Cited by 879 · see citing works
“Despite this limitation, the automated Neurosynth software has been highly successful at replicating findings using manually coded methods and decoding broad cognitive states in individual human subjects (Yarkoni et al. 2011), and we are currently working to improve specificity via alternative coding”
BackgroundMethodResultInfluentialSelf-citationRepresentational geometry: integrating cognition, computation, and the brain
Kriegeskorte, N., & Kievit, R. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.06.007 · Cited by 898 · see citing works
The neural network of motor imagery: An ALE meta-analysis
Hétu, S., Grégoire, M., Saimpont, A., Coll, M., Eugène, F., Michon, P., & Jackson, P. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.017 · Cited by 900 · see citing works
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
Self-citationThe neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844 · see citing works
Self-citationInferring mental states from neuroimaging data: from reverse inference to large-scale decoding
Poldrack, R. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.11.001 · Cited by 821 · see citing works
Self-citationHansen, J. Y., Shafiei, G., Markello, R. D., Smart, K., Cox, S. M. L., Nørgaard, M., Beliveau, V., Wu, Y., Gallezot, J.-D., Aumont, É., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01186-3 · Cited by 797 · see citing works
BrainGNN: Interpretable Brain Graph Neural Network for fMRI Analysis
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Sescousse, G., Caldú, X., Segura, B., & Dreher, J.-C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.002 · Cited by 782 · see citing works
“Importantly, recent studies using large-scale reverse inferences have suggested that the ventral striatum has a relatively specific role in reward processing, as compared to other cognitive processes (Cauda et al., 2011; Yarkoni et al., 2011).”
Bernhardt, B. C., & Singer, T. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150536 · Cited by 952 · see citing works
“F or p er so na l u se o nl y. repetition suppression study design may help to elucidate further the exact role of different regions involved in empathic networks (Bullmore & Sporns 2009, Caruana et al. 2011, Kurth et al. 2010, Shamay-Tsoory et al. 2009, Yarkoni et al. 2011).”
BackgroundTen simple rules for neuroimaging meta-analysis
Müller, V. I., Cieslik, E. C., Laird, A. R., Fox, P. T., Radua, J., Mataix-Cols, D., Tench, C. R., Yarkoni, T., Nichols, T. E., Turkeltaub, P. E., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.012 · Cited by 805 · see citing works
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Informatic parcellation of the network involved in the computation of subjective value
Clithero, J. A., & Rangel, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst106 · Cited by 706 · see citing works
Emotion and the prefrontal cortex: an integrative review
Dixon, M. L., Thiruchselvam, R., Todd, R., & Christoff, K. (2017) · Psychological Bulletin · doi:10.1037/bul0000096 · Cited by 745 · see citing works
On testing for spatial correspondence between maps of human brain structure and function
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Nociception, pain, negative moods, and behavior selection
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Eickhoff, S. B., Nichols, T. E., Laird, A. R., Hoffstaedter, F., Amunts, K., Fox, P. T., Bzdok, D., & Eickhoff, C. R. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.072 · Cited by 683 · see citing works
“…topics from cognitive (Chase et al., 2015; Molenberghs et al., 2012), affective (Kohn et al., 2014; Lamm et al., 2011) and motor (King et al., 2014; Yuan and Brown, 2015) neuroscience to the neurobiology of neurological (Herz et al., 2014; Rehme et al., 2012) and psychiatric (Bludau et al., 2015;…”
Self-citationCognitive and behavioural flexibility: Neural mechanisms and clinical considerations
Uddin, L. Q. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00428-w · Cited by 698 · see citing works
States of Curiosity Modulate Hippocampus-Dependent Learning via the Dopaminergic Circuit
Gruber, M. J., Gelman, B. D., & Charan Ranganath, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.060 · Cited by 742 · see citing works
“Accordingly, we used the NeuroSynth tool (Yarkoni et al., 2011) to conduct a meta-analysis based on 329 studies of reward processing in order to identify voxels within the three regions that are reliably recruited during extrinsic motivational states (see Methods and Figure S1).”
BackgroundMethodInfluentialSydnor, V. J., Larsen, B., Bassett, D. S., Alexander‐Bloch, A. F., Fair, D. A., Liston, C. M., Mackey, A. P., Milham, M. P., Pines, A. R., Roalf, D. R., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.016 · Cited by 725 · see citing works
Shared memories reveal shared structure in neural activity across individuals
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Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence
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“NeuroSynth (Yarkoni et al., 2011), which identifies locations with a high”
BackgroundMethodSelf-citationThe Neural Bases of Distraction and Reappraisal
McRae, K., Hughes, B., Chopra, S., Gabrieli, J. D. E., Gross, J. J., & Ochsner, K. N. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21243 · Cited by 642 · see citing works
Barrett, L. F., & Satpute, A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.012 · Cited by 58 · see citing works
Peters, S. K., Dunlop, K., & Downar, J. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00104 · Cited by 611 · see citing works
“The interested reader can readily perform an independent replication of this map of regions by using the online, automated meta-analytic tool Neurosynth (Yarkoni et al., 2011; Figure 2).”
MethodDixon, M. L., De La Vega, A., Mills, C., Andrews-Hanna, J., Spreng, R. N., Cole, M. W., & Christoff, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715766115 · Cited by 595 · see citing works
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“Meta-analytic decoding (www.neurosynth.org; Yarkoni et al., 2011) results are given in polar plots, expressed as image correlation, that is, Pearson’s r.”
BackgroundMethodInfluentialBoly, M., Massimini, M., Tsuchiya, N., Postle, B. R., Koch, C., & Tononi, G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3218-16.2017 · Cited by 557 · see citing works
“org) (Yarkoni et al., 2011) combines an automated tool to extract activation coordinates with a taxonomy of cognitive processes that includes a few entries for consciousness.”
MethodAnterior hippocampus: the anatomy of perception, imagination and episodic memory
Zeidman, P., & Maguire, E. A. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.24 · Cited by 542 · see citing works
Kong, R., Li, J., Orbán, C., Sabuncu, M. R., Liu, H., Schaefer, A., Sun, N., Zuo, X., Holmes, A. J., Eickhoff, S. B., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy123 · Cited by 581 · see citing works
A Review of Feature Reduction Techniques in Neuroimaging
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Gorgolewski, K. J., Varoquaux, G. P., Rivera, G., Schwarz, Y., Ghosh, S., Maumet, C., Sochat, V., Nichols, T. E., Poldrack, R. A., Poline, J., et al. (2015) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2015.00008 · Cited by 554 · see citing works
Self-citationMicrostructural and functional gradients are increasingly dissociated in transmodal cortices
Paquola, C., de Wael, R. V., Wagstyl, K., Bethlehem, R. A. I., Hong, S., Seidlitz, J., Bullmore, E. T., Evans, A. C., Mišić, B., Margulies, D. S., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000284 · Cited by 490 · see citing works
neuromaps: structural and functional interpretation of brain maps
Markello, R. D., Hansen, J. Y., Liu, Z.-Q., Bazinet, V., Shafiei, G., Suárez, L. E., Blostein, N., Seidlitz, J., Baillet, S., Satterthwaite, T. D., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01625-w · Cited by 479 · see citing works
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Seidlitz, J., Váša, F., Shinn, M., Romero-García, R., Whitaker, K. J., Vértes, P. E., Wagstyl, K., Reardon, P. K., CLASEN, L. S., Liu, S., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.039 · Cited by 488 · see citing works
Midcingulate cortex: Structure, connections, homologies, functions and diseases
Vogt, B. A. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.01.010 · Cited by 471 · see citing works
Consumer Neuroscience: Applications, Challenges, and Possible Solutions
Plaßmann, H., Venkatraman, V., Huettel, S. A., & Yoon, C. (2015) · Journal of Marketing Research · doi:10.1509/jmr.14.0048 · Cited by 517 · see citing works
Imaging-based parcellations of the human brain
Eickhoff, S. B., Yeo, B. T. T., & Genon, S. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0071-7 · Cited by 484 · see citing works
Li, X., Gu, Y., Dvornek, N., Staib, L. H., Ventola, P., & Duncan, J. S. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101765 · Cited by 480 · see citing works
“Further, we listed the correlations between the biomarkers with functional keyword maps in Table IV by Neurosynth [47].”
MethodInternet Research in Psychology
Gosling, S. D., & Mason, W. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015321 · Cited by 458 · see citing works
Davey, J., Thompson, H. E., Hallam, G., Karapanagiotidis, T., Murphy, C., De Caso, I., Krieger-Redwood, K., Bernhardt, B. C., Smallwood, J., & Jefferies, E. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.05.051 · Cited by 433 · see citing works
Atlas, L. Y., & Wager, T. D. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.039 · Cited by 463 · see citing works
Self-citationA nexus model of the temporal–parietal junction
Carter, R. M., & Huettel, S. A. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.05.007 · Cited by 489 · see citing works
Functional Specialization and Flexibility in Human Association Cortex
Yeo, B. T. T., Krienen, F. M., Eickhoff, S. B., Yaakub, S. N., Fox, P. T., Buckner, R. L., Asplund, C. L., & Chee, M. W. L. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu217 · Cited by 437 · see citing works
Psychopathology and the Human Connectome: Toward a Transdiagnostic Model of Risk For Mental Illness
Buckholtz, J. W., & Meyer‐Lindenberg, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.002 · Cited by 433 · see citing works
“…cognitive ontologies that enable classifier-based and meta-analytic parsing of cognitive constructs (Bilder et al., 2009; Poldrack et al., 2011), and large-scale syntheses of fMRI data that permit decoding of brain activity patterns for these constructs via similar methods (Yarkoni et al., 2011).”
Making big data open: data sharing in neuroimaging
Poldrack, R. A., & Gorgolewski, K. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3818 · Cited by 412 · see citing works
Self-citationThe cognitive atlas: toward a knowledge foundation for cognitive neuroscience
Poldrack, R. A., Kittur, A., Kalar, D., Miller, E., Seppa, C., Gil, Y., Parker, D. S., Sabb, F. W., & Bilder, R. M. (2011) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2011.00017 · Cited by 385 · see citing works
Self-citationCieslik, E. C., Zilles, K., Caspers, S., Roski, C., Kellermann, T. S., Jakobs, O., Langner, R., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs256 · Cited by 391 · see citing works
“One might even ask whether it is possible at all to define the functional role of the DLPFC with classic functional magnetic resonance imaging (fMRI), since this brain region is involved in a variety of cognitive processes (cf. Yarkoni et al. 2011).”
BackgroundDeficient approaches to human neuroimaging
Stelzer, J., Lohmann, G., Mueller, K., Buschmann, T., & Turner, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00462 · Cited by 413 · see citing works
“Most critically, such data mining should not be based on the reported results of individual studies [such as the Neurosynth project (Yarkoni et al., 2011)], because their results suffer from the same plethora of false positive and negative voxels, and mislocalization of activation maxima.”
ResultA Primer on Pattern-Based Approaches to fMRI: Principles, Pitfalls, and Perspectives
Haynes, J.-D. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.025 · Cited by 402 · see citing works
“As mentioned above, estimating the full p(rjs) is not tractable because it would require measuring brain responses to all possible stimuli (but see Yarkoni et al., 2011).”
BackgroundVisceral Signals Shape Brain Dynamics and Cognition
Azzalini, D., Rebollo, I., & Tallon-Baudry, C. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.03.007 · Cited by 409 · see citing works
A functional architecture of the human brain: emerging insights from the science of emotion
Lindquist, K. A., & Barrett, L. F. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.09.005 · Cited by 405 · see citing works
Deconstructing and reconstructing theory of mind
Schaafsma, S. M., Pfaff, D. W., Spunt, R. P., & Adolphs, R. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.11.007 · Cited by 498 · see citing works
“This, after all, is precisely the point of a tool such as Neurosynth [41]: it is data-driven with the aim to map activation patterns to processes.”
InfluentialDecoding the Nature of Emotion in the Brain
Kragel, P. A., & LaBar, K. S. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.03.011 · Cited by 388 · see citing works
“(A) Probabilistic reverse-inference maps from an automated meta-analysis of the neuroimaging literature [62] indicate the probability of a study including the terms ‘arousal’ (227 studies), ‘unpleasant’ (106 studies), or ‘fear’ (298 studies) given the observed activation.”
MethodRudolph, M. D., Graham, A. M., Feczko, E., Miranda-Dominguez, O., Rasmussen, J. M., Nardos, R., Entringer, S., Wadhwa, P. D., Buss, C., & Fair, D. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0128-y · Cited by 374 · see citing works
A convergent functional architecture of the insula emerges across imaging modalities
Kelly, C., Toro, R., Di Martino, A., Cox, C. L., Bellec, P., Castellanos, F. X., & Milham, M. P. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.021 · Cited by 374 · see citing works
“Indeed, more comprehensive and detailed text-based meta-analytic methods, such as those implemented in NeuroSynth (Yarkoni et al., 2011), may be required to derive a thorough and representative mapping of insular functional domains.”
The Default Mode Network in Autism
Padmanabhan, A., Lynch, C. J., Schaer, M., & Menon, V. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.004 · Cited by 381 · see citing works
Social Pain and the Brain: Controversies, Questions, and Where to Go from Here
Eisenberger, N. I. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115146 · Cited by 381 · see citing works
“To explore this question, we1 have recently used a publicly available database of over 5,800 neuroimaging studies, Neurosynth (neurosynth.org; Yarkoni et al. 2011), to examine reverse inference maps for pain as well as for other salience-relevant psychological processes, including control,…”
MethodKrienen, F. M., Yeo, B. T. T., & Buckner, R. L. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0526 · Cited by 372 · see citing works
“The whole-cortex fcMRI global coupling profile measured during passive rest was correlated with the coactivation patterns derived from the NeuroSynth database [75] (http://neurosynth.”
MethodFrom Brain Maps to Cognitive Ontologies: Informatics and the Search for Mental Structure
Poldrack, R. A., & Yarkoni, T. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033729 · Cited by 358 · see citing works
“Drawing on such databases and tools, researchers have conducted hundreds of fMRI metaanalyses on topics ranging from single-word reading (Turkeltaub et al. 2002) to rectal distension in irritable bowel syndrome (Tillisch et al. 2011).”
BackgroundMethodSelf-citationAdvanced lesion symptom mapping analyses and implementation as BCBtoolkit
Foulon, C., Cerliani, L., Kinkingnéhun, S., Lévy, R., Rosso, C., Urbanski, M., Emmanuelle Volle, C., & de Schotten, M. T. (2018) · GigaScience · doi:10.1093/gigascience/giy004 · Cited by 359 · see citing works
Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks
Vidaurre, D., Hunt, L. T., Quinn, A. J., Hunt, B. A. E., Brookes, M. J., Nobre, A. C., & Woolrich, M. W. (2018) · Nature Communications · doi:10.1038/s41467-018-05316-z · Cited by 362 · see citing works
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
The relation between statistical power and inference in fMRI
Cremers, H. R., Wager, T. D., & Yarkoni, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184923 · Cited by 336 · see citing works
Self-citationA Sensitive and Specific Neural Signature for Picture-Induced Negative Affect
Chang, L. J., Gianaros, P. J., Manuck, S. B., Krishnan, A., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002180 · Cited by 336 · see citing works
“This is consistent with our previous work demonstrating that pain is distinct from other emotional processes based on distributed spatial topography both across brain regions [28] and within local regions [35,67].”
BackgroundResultSelf-citationTracking ongoing cognition in individuals using brief, whole-brain functional connectivity patterns
González-Castillo, J., Hoy, C. W., Handwerker, D. A., Robinson, M. E., Buchanan, L. C., Saad, Z. S., & Bandettini, P. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501242112 · Cited by 344 · see citing works
Toward open sharing of task-based fMRI data: the OpenfMRI project
Poldrack, R. A., Barch, D. M., Mitchell, J. P., Wager, T. D., Wagner, A. D., Devlin, J. T., Cumba, C., Koyejo, S., & Milham, M. P. (2013) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2013.00012 · Cited by 341 · see citing works
“These include Brainmap (http://www . brainmap . org) (Laird et al., 2005), SumsDB (http://sumsdb . wustl . edu/sums/), and Neurosynth (http://www . neurosynth . org) (Yarkoni et al., 2011), each of which provides tools to perform coordinate-based meta-analyses.”
BackgroundMethodSelf-citationComparing spatial null models for brain maps
Markello, R. D., & Mišić, B. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118052 · Cited by 343 · see citing works
“…( Vos de Wael et al., 2020 ), IPython ( Pérez and Granger, 2007 ), Jupyter ( Kluyver et al., 2016 ), Matplotlib ( Hunter, 2007 ), NeuroSynth ( Yarkoni et al., 2011 ), NiBabel ( Brett et al., 2020 ), NumPy ( Oliphant, 2006; Van Der Walt et al., 2011 ), Pandas ( McKinney, 2010 ), PySurfer (…”
InfluentialCausal mapping of human brain function
Siddiqi, S., Kording, K. P., Parvizi, J., & Fox, M. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00583-8 · Cited by 343 · see citing works
Hanson, J. L., Hariri, A. R., & Williamson, D. E. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.010 · Cited by 338 · see citing works
A Synergistic Core for Human Brain Evolution and Cognition
Luppi, A. I., Mediano, P. A. M., Rosas, F. E., Holland, N., Fryer, T. D., O’Brien, J. T., Rowe, J. B., Menon, D. K., Bor, D., & Stamatakis, E. A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01070-0 · Cited by 314 · see citing works
Multi-echo fMRI: A review of applications in fMRI denoising and analysis of BOLD signals
Kundu, P., Voon, V., Balchandani, P., Lombardo, M. V., Poser, B. A., & Bandettini, P. A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.033 · Cited by 324 · see citing works
Revisiting the role of the insula in addiction
Droutman, V., Read, S. J., & Bechara, A. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.005 · Cited by 317 · see citing works
When Math Hurts: Math Anxiety Predicts Pain Network Activation in Anticipation of Doing Math
Lyons, I. M., & Beilock, S. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048076 · Cited by 329 · see citing works
Separate neural representations for physical pain and social rejection
Woo, C.-W., Koban, L., Kross, E., Lindquist, M. A., Banich, M. T., Ruzic, L., Andrews-Hanna, J. R., & Wager, T. D. (2014) · Nature Communications · doi:10.1038/ncomms6380 · Cited by 310 · see citing works
Self-citationAndrews-Hanna, J. R., Saxe, R., & Yarkoni, T. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.032 · Cited by 313 · see citing works
Self-citationThe impact of the human thalamus on brain-wide information processing
Shine, J. M., Lewis, L. D., Garrett, D. D., & Hwang, K. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00701-0 · Cited by 308 · see citing works
Longitudinal Growth Curves of Brain Function Underlying Inhibitory Control through Adolescence
Ordaz, S. J., Foran, W., Velanova, K., & Luna, B. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1741-13.2013 · Cited by 302 · see citing works
“…generate unbiased ROIs based on the large extant literature, central coordinates were identified using the Neurosynth platform and database (www.Neurosynth.org, accessed March, 2012), a meta-analytic program that generates voxelwise statistical maps for a given term or topic (Yarkoni et al., 2011).”
Method
- Authors
- Yarkoni, T., Poldrack, R. A., Nichols, T. E., Van Essen, D. C., & Wager, T. D.
- Affiliations
- University of Colorado Boulder (US)
- The University of Texas at Austin (US)
- University of Warwick (GB)
- Corresponding author
- Yarkoni, Tal
- Venue
- Nature Methods
- Published
- 2011-06-26
- Volume
- 8
- Issue
- 8
- Pages
- 665-670
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- PMC
- PMC3146590
- OpenAlex
- W2124757386
- Cited by
- 3,686
- References
- 45
- Citations by year
- 2026: 238 · 2025: 371 · 2024: 355 · 2023: 286 · 2022: 362 · 2021: 364 · 2020: 322 · 2019: 280 · 2018: 303 · 2017: 212 · 2016: 191 · 2015: 147 · 2014: 98 · 2013: 80 · 2012: 60
- FWCI
- 40.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH060974, R01MH082795, R01MH076136)
- National Institute on Drug Abuse (RC1DA028608, R01DA027794)
- National Institute of Nursing Research (F32NR012081)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
- Social Sciences › General Social Sciences › Computational and Text Analysis Methods
- Keywords
- text mining, cognitive state decoding, machine learning, web interface
- MeSH terms
- Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Natural Language Processing, Periodicals as Topic, Software, Internet, Data Mining
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-18.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-18.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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