Dissociable auditory mismatch response and connectivity patterns in adolescents with schizophrenia and adolescents with bipolar disorder with psychosis: A magnetoencephalography study
Open accessAbstract
Background There is overlap between schizophrenia and bipolar disorder regarding genetic risk as well as neuropsychological and structural brain deficits. Finding common and distinct event-response potential (ERP) responses and connectivity patterns may offer potential biomarkers to distinguish the disorders.Objective To examine the neuronal auditory response elicited by a roving mismatch negativity (MMN) paradigm using magnetoencephalography (MEG).Participants 15 Adolescents with schizophrenia (ASZ), 16 adolescents with bipolar disorder with psychosis (ABP), and 14 typically developing individuals (TD) METHODS: The data were analysed using time-series techniques and dynamic causal modelling (DCM).Outcome measures MEG difference wave (deviant - standard) at primary auditory (~90ms), MMN (~180ms) and long latency (~300ms).Results The amplitude of difference wave showed specific patterns at all latencies. Most notably, it was significantly reduced ABP compared to both controls and ASZ at early latencies. In contrast, the amplitude was significantly reduced in ASZ compared to both controls and ABP. The DCM analysis showed differential connectivity patterns in all three groups. Most notably, inter-hemispheric connections were strongly dominated by the right side in ASZ only.Conclusions Dissociable patterns of the primary auditory response and MMN response indicate possible developmentally sensitive, but separate biomarkers for schizophrenia and bipolar disorder.
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Braeutigam et al. found DCM selected different models among schizophrenia, bipolar disorder, and healthy controls.
“DCM selected different models among schizophrenia, bipolar disorder, and healthy controls.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [45]
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Mismatch negativity (MMN) as a tool for translational investigations into early psychosis: A review
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A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia
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- Authors
- Braeutigam, S., Dima, D., Frangou, S., & James, A.
- Affiliations
- University of Oxford (GB)
- University of London (GB)
- Icahn School of Medicine at Mount Sinai (US)
- Warneford Hospital (GB)
- Corresponding author
- Braeutigam, Sven
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 193
- Pages
- 313-318
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2739603642
- Cited by
- 20
- References
- 49
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by-nc-nd)
- City Research Online (City University London) (acceptedVersion)
- Funders
- Oxford University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- mismatch negativity, schizophrenia
- MeSH terms
- Acoustic Stimulation, Adolescent, Bipolar Disorder, Brain Mapping, Contingent Negative Variation, Electroencephalography, Evoked Potentials, Auditory, Female, Humans, Male, Models, Neurological, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Reaction Time, Schizophrenia, Magnetoencephalography
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