Mismatch negativity (MMN) as a tool for translational investigations into early psychosis: A review

Tada, Mariko; Kirihara, Kenji; Mizutani, Shunsuke; Uka, Takanori; Kunii, Naoto; Koshiyama, Daisuke; Fujioka, Mao; Usui, Kaori; Nagai, Tatsuya; Araki, Tsuyoshi; Kasai, Kiyoto

doi:10.1016/j.ijpsycho.2019.02.009

Cited by 74Schizophrenia research and treatmentNeural dynamics and brain functionNeuroscience and Music Perception

Mismatch negativity (MMN) as a tool for translational investigations into early psychosis: A review

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Tada, Mariko, Kirihara, Kenji, Mizutani, Shunsuke, Uka, Takanori, Kunii, Naoto, Koshiyama, Daisuke, Fujioka, Mao, Usui, Kaori +3 more·2019·International Journal of Psychophysiology

DOI 10.1016/j.ijpsycho.2019.02.009

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Abstract

Mismatch negativity (MMN) reduction is one of the most robust findings among several neurophysiological and neurocognitive measures in patients with schizophrenia. MMN is a promising biomarker for schizophrenia because of the following properties: 1) its relationship with early psychosis, including clinical high-risk (CHR); 2) its relationship with the functional abilities of patients; and 3) its translatability into basic research using animal models. Specifically, the utility of the passive auditory oddball paradigm that does not require subjects to make behavioral responses enables identical physiological activities to be obtained from both experimental animals and patients. This advantage has contributed to clarifying the generating mechanism of MMN in various animal studies. We reviewed clinical reports focused on early psychosis; specifically differential effects of deviance type and relationships to clinical and functional outcome. For the utility of MMN as a tool for translational research, we next reviewed recent MMN studies in rodents and nonhuman primates (NHP) as well as studies using intracranial recordings in humans, a rare opportunity to detect neural signals in vivo in humans. Neural computations of MMN, such as adaptation, deviance detection, and predictive coding, have been recent topics for understanding MMN generating mechanisms. Finally, several significant research questions were provided for future directions. MMN research could contribute to innovative, novel, therapeutic strategies in the future by becoming a bridge between basic and clinical research.

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Recent studies have explained reduced MMN as altered predictive coding in schizophrenia.
“Based on these findings, recent studies have explained reduced MMN as altered predictive coding in schizophrenia (12, 24).”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [24]
Section 4 describes predictive coding as a proposed mechanism for MMN and says recent studies suggest altered predictive coding may be related to schizophrenia. It also says MMN’s underlying neural computation remains under debate, so the review does not establish altered predictive coding as the explanation for reduced MMN. (LLM, conf=0.82)
Experimental — accuracy not yet measured
MMN can serve as a translational biomarker.
“Because MMN can serve as a translational biomarker (24), animal studies measuring MMN can be used to investigate neurobiological mechanisms underlying altered predictive coding in schizophrenia.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [24]
MMN is considered a translatable biomarker because paradigms for the measurement of MMN can be applied to non-human animals.
“MMN is considered a translatable biomarker because paradigms for the measurement of MMN can be applied to non-human animals (24).”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [24]

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Dynamic causal modelling
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583 · see citing works
Early selective-attention effect on evoked potential reinterpreted
Näätänen, R., Gaillard, A. W. K., & Mäntysalo, S. (1978) · Acta Psychologica · doi:10.1016/0001-6918(78)90006-9 · Cited by 2,725 · see citing works
Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental States
Yung, A. R., Yung, A. R., Yuen, H. P., McGorry, P. D., Phillips, L., Kelly, D., Dell’Olio, M., Francey, S. M., Cosgrave, E., Killackey, E. J., et al. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01714.x · Cited by 2,195 · see citing works
The mismatch negativity: a review of underlying mechanisms
Garrido, M. I., Kilner, J. M., Stephan, K. E., & Friston, K. J. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.11.029 · Cited by 1,441 · see citing works
Processing of low-probability sounds by cortical neurons
Ulanovsky, N., Las, L., & Nelken, I. (2003) · Nature Neuroscience · doi:10.1038/nn1032 · Cited by 1,049 · see citing works
From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment
Moghaddam, B., & Javitt, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.181 · Cited by 1,035 · see citing works
Prospective Diagnosis of the Initial Prodrome for Schizophrenia Based on the Structured Interview for Prodromal Syndromes: Preliminary Evidence of Interrater Reliability and Predictive Validity
Miller, T. J., McGlashan, T. H., Rosen, J. L., Somjee, L., Markovich, P. J., Stein, K., & Woods, S. W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.863 · Cited by 872 · see citing works
Brain disorders? Precisely
Insel, T. R., & Cuthbert, B. N. (2015) · Science · doi:10.1126/science.aab2358 · Cited by 840 · see citing works
Mismatch negativity in schizophrenia: a meta-analysis
Umbricht, D., & Krljes, S. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.12.002 · Cited by 742 · see citing works
Neural signature of the conscious processing of auditory regularities
Bekinschtein, T. A., Dehaene, S., Rohaut, B., Tadel, F., Cohen, L., & Naccache, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809667106 · Cited by 738 · see citing works
Learning and inference in the brain
Friston, K. (2003) · Neural Networks · doi:10.1016/j.neunet.2003.06.005 · Cited by 724 · see citing works
Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.
Javitt, D. C., Steinschneider, M., Schroeder, C. E., & Arezzo, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11962 · Cited by 662 · see citing works
Attentive novelty detection in humans is governed by pre-attentive sensory memory
Tiitinen, H., May, P., Reinikainen, K., & Näätänen, R. (1994) · Nature · doi:10.1038/372090a0 · Cited by 637 · see citing works
Promises and limitations of human intracranial electroencephalography
Parvizi, J., & Kastner, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0108-2 · Cited by 631 · see citing works
Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained
May, P. J. C., & Tiitinen, H. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00856.x · Cited by 549 · see citing works
A neuronal model of predictive coding accounting for the mismatch negativity.
Wacongne, C., Changeux, J.-P., & Dehaene, S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5003-11.2012 · Cited by 542 · see citing works
Intracerebral potentials to rare target and distractor auditory and visual stimuli. I. Superior temporal plane and parietal lobe
Halgren, E., Baudena, P., Clarke, J. M., Heit, G., Liégeois‐Chauvel, C., Chauvel, P., & Musolino, A. (1995) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)00259-n · Cited by 513 · see citing works
High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research
Lachaux, J.-P., Axmacher, N., Mormann, F., Halgren, E., & Crone, N. E. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.008 · Cited by 501 · see citing works
Human posterior auditory cortex gates novel sounds to consciousness
Jääskeläinen, I. P., Ahveninen, J., Bonmassar, G., Dale, A. M., Ilmoniemi, R. J., Levänen, S., Lin, F., May, P., Melcher, J. R., Stufflebeam, S. M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303760101 · Cited by 464 · see citing works
The functional anatomy of the MMN: a DCM study of the roving paradigm
Garrido, M. I., Friston, K. J., Kiebel, S. J., Stephan, K. E., Baldeweg, T., & Kilner, J. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.018 · Cited by 458 · see citing works
The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions
Näätänen, R., Kujala, T., Escera, C., Baldeweg, T., Kreegipuu, K., Carlson, S., & Ponton, C. W. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.09.020 · Cited by 426 · see citing works
A Meta-Analysis of Mismatch Negativity in Schizophrenia: From Clinical Risk to Disease Specificity and Progression
Erickson, M. A., Ruffle, A., & Gold, J. M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.025 · Cited by 426 · see citing works
Mismatch Negativity Deficits Are Associated With Poor Functioning in Schizophrenia Patients
Light, G. A., & Braff, D. L. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.127 · Cited by 407 · see citing works
The Neural Circuitry of Pre-attentive Auditory Change-detection: An fMRI Study of Pitch and Duration Mismatch Negativity generators
Molholm, S., Martı́nez, A., Ritter, W., Javitt, D. C., & Foxe, J. J. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh155 · Cited by 397 · see citing works
Progressive and Interrelated Functional and Structural Evidence of Post-Onset Brain Reduction in Schizophrenia
Salisbury, D. F., Kuroki, N., Kasai, K., Shenton, M. E., & McCarley, R. W. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.5.521 · Cited by 379 · see citing works
Self-citation
Auditory dysfunction in schizophrenia: integrating clinical and basic features
Javitt, D. C., & Sweet, R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4002 · Cited by 363 · see citing works
Are screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview
Kelleher, I., Harley, M., Murtagh, A., & Cannon, M. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp057 · Cited by 352 · see citing works
Neurons along the auditory pathway exhibit a hierarchical organization of prediction error
Parras, G. G., Nieto-Diego, J., Carbajal, G. V., Valdés-Baizabal, C., Escera, C., & Malmierca, M. S. (2017) · Nature Communications · doi:10.1038/s41467-017-02038-6 · Cited by 344 · see citing works
High Gamma Activity in Response to Deviant Auditory Stimuli Recorded Directly From Human Cortex
Edwards, E., Soltani, M., Deouell, L. Y., Berger, M. S., & Knight, R. T. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00324.2005 · Cited by 334 · see citing works
Prediction of Psychosis by Mismatch Negativity
Bodatsch, M., Ruhrmann, S., Wagner, M., Müller, R., Schultze‐Lutter, F., Frommann, I., Brinkmeyer, J., Gäebel, W., Maier, W., Klosterkötter, J., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.057 · Cited by 284 · see citing works
Evoked potential correlates of stimulus deviance during wakefulness and sleep in cat — animal model of mismatch negativity
Csépe, V., Karmos, G., & Molnár, M. (1987) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(87)90103-9 · Cited by 266 · see citing works
Deviant matters: duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia
Todd, J., Michie, P. T., Schall, U., Karayanidis, F., Yabe, H., & Näätänen, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.016 · Cited by 257 · see citing works
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
Perez, V. B., Woods, S. W., Roach, B. J., Ford, J. M., McGlashan, T. H., Srihari, V. H., & Mathalon, D. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.038 · Cited by 246 · see citing works
Capturing the Angel in "Angel Dust": Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans
Moghaddam, B., & Krystal, J. H. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs075 · Cited by 238 · see citing works
Measuring duration mismatch negativity
Jacobsen, T., & Schröger, E. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00043-9 · Cited by 238 · see citing works
Large-scale cortical networks for hierarchical prediction and prediction error in the primate brain
Chao, Z. C., Takaura, K., Wang, L., Fujii, N., & Dehaene, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.004 · Cited by 238 · see citing works
Glutamatergic model psychoses: prediction error, learning, and inference
Corlett, P. R., Honey, G. D., Krystal, J. H., & Fletcher, P. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.163 · Cited by 229 · see citing works
Detection of stimulus deviance within primate primary auditory cortex: intracortical mechanisms of mismatch negativity (MMN) generation
Javit, D. C., Steinschneider, M., Schroeder, C. E., Vaughan, H. G., & Arezzo, J. C. (1994) · Brain Research · doi:10.1016/0006-8993(94)91496-6 · Cited by 219 · see citing works
Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia
Thomas, M. L., Green, M. F., Hellemann, G., Sugar, C. A., Tarasenko, M., Calkins, M. E., Greenwood, T. A., Gur, R. E., Gur, R. C., Lazzeroni, L. C., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2980 · Cited by 206 · see citing works
Duration Mismatch Negativity and P3a in First-Episode Psychosis and Individuals at Ultra-High Risk of Psychosis
Atkinson, R. J., Michie, P. T., & Schall, U. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.023 · Cited by 204 · see citing works
Single-trial decoding of auditory novelty responses facilitates the detection of residual consciousness
King, J. R., Faugeras, F., Gramfort, A., Schurger, A., El Karoui, I., Sitt, J. D., Rohaut, B., Wacongne, C., Labyt, E., Bekinschtein, T., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.013 · Cited by 197 · see citing works
Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex
Kropotov, J. D., NÄÄÄNEN, R., Sevostianov, A. V., Alho, K., Reinikainen, K., & Kropotova, O. V. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb01226.x · Cited by 196 · see citing works
Mismatch Negativity, Social Cognition, and Functioning in Schizophrenia Patients
Wynn, J. K., Sugar, C. A., Horan, W. P., Kern, R. S., & Green, M. F. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.024 · Cited by 194 · see citing works
Automatic sensory information processing abnormalities across the illness course of schizophrenia
Jahshan, C. S., Cadenhead, K. S., Rissling, A. J., Kirihara, K., BRAFF, D. L., & Light, G. A. (2011) · Psychological Medicine · doi:10.1017/s0033291711001061 · Cited by 190 · see citing works
Self-citation
Characterization of Neurophysiologic and Neurocognitive Biomarkers for Use in Genomic and Clinical Outcome Studies of Schizophrenia
Light, G. A., Swerdlow, N. R., Rissling, A. J., Radant, A. D., Sugar, C. A., Sprock, J., Pela, M., Geyer, M. A., & BRAFF, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039434 · Cited by 189 · see citing works
Complementary control of sensory adaptation by two types of cortical interneurons
Natan, R. G., Briguglio, J. J., Mwilambwe-Tshilobo, L., Jones, S. I., Aizenberg, M., Goldberg, E. M., & Geffen, M. N. (2015) · eLife · doi:10.7554/elife.09868 · Cited by 189 · see citing works
Stimulus-Specific Adaptation in Auditory Cortex Is an NMDA-Independent Process Distinct from the Sensory Novelty Encoded by the Mismatch Negativity
Farley, B. J., Quirk, M. C., Doherty, J. J., & Christian, E. P. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2793-10.2010 · Cited by 183 · see citing works
Nonhuman primate model of schizophrenia using a noninvasive EEG method
Gil-da-Costa, R., Stoner, G. R., Fung, R., & Albright, T. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312264110 · Cited by 182 · see citing works
Demonstration of mismatch negativity in the monkey
Javitt, D. C., Schroeder, C. E., Steinschneider, M., Arezzo, J. C., & Vaughan, H. G. (1992) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(92)90137-7 · Cited by 179 · see citing works
Searching for the Mismatch Negativity in Primary Auditory Cortex of the Awake Monkey: Deviance Detection or Stimulus Specific Adaptation?
Fishman, Y. I., & Steinschneider, M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2835-12.2012 · Cited by 174 · see citing works
Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus
Sweet, R. A., Dorph‐Petersen, K., & Lewis, D. A. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20702 · Cited by 168 · see citing works
Representation of Numerical and Sequential Patterns in Macaque and Human Brains
Wang, L., Uhrig, L., Jarraya, B., & Dehaene, S. (2015) · Current Biology · doi:10.1016/j.cub.2015.06.035 · Cited by 166 · see citing works
Somatostatin Interneurons Control a Key Component of Mismatch Negativity in Mouse Visual Cortex
Hamm, J. P., & Yuste, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.037 · Cited by 165 · see citing works
Hierarchy of prediction errors for auditory events in human temporal and frontal cortex
Dürschmid, S., Edwards, E., Reichert, C., Dewar, C., Hinrichs, H., Heinze, H.-J., Kirsch, H. E., Dalal, S. S., Deouell, L. Y., & Knight, R. T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525030113 · Cited by 161 · see citing works
Gray Matter Deficits, Mismatch Negativity, and Outcomes in Schizophrenia
Rasser, P. E., Schall, U., Todd, J., Michie, P. T., Ward, P. B., Johnston, P., Helmbold, K., Case, V., Soyland, A., Tooney, P. A., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp060 · Cited by 159 · see citing works
Future clinical uses of neurophysiological biomarkers to predict and monitor treatment response for schizophrenia
Light, G. A., & Swerdlow, N. R. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12730 · Cited by 156 · see citing works
Discrimination of speech-like contrasts in the auditory thalamus and cortex
Kraus, N., McGee, T., Carrell, T. D., King, C. D., Littman, T. A., & Nicol, T. G. (1994) · The Journal of the Acoustical Society of America · doi:10.1121/1.411282 · Cited by 151 · see citing works
Reduced mismatch negativity predates the onset of psychosis
Shaikh, M., Valmaggia, L., Broome, M. R., Dutt, A., Lappin, J., Day, F., Woolley, J., Tabraham, P., Walshe, M., Johns, L., et al. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.022 · Cited by 150 · see citing works
Rhesus Monkeys (Macaca mulatta) Detect Rhythmic Groups in Music, but Not the Beat
Honing, H., Merchant, H., Háden, G. P., Prado, L., & Bartolo, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051369 · Cited by 148 · see citing works
Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia
Brockhaus‐Dumke, A., Tendolkar, I., Pukrop, R., Schultze‐Lutter, F., Klosterkötter, J., & Ruhrmann, S. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.05.016 · Cited by 146 · see citing works
Localizing pre-attentive auditory memory-based comparison: Magnetic mismatch negativity to pitch change
Maeß, B., Jacobsen, T., Schröger, E., & Friederici, A. D. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.040 · Cited by 145 · see citing works
Mismatch Negativity in First-Episode Schizophrenia
Haigh, S. M., Coffman, B. A., & Salisbury, D. F. (2016) · Clinical EEG and Neuroscience · doi:10.1177/1550059416645980 · Cited by 145 · see citing works
Specific Early and Late Oddball-Evoked Responses in Excitatory and Inhibitory Neurons of Mouse Auditory Cortex
Chen, I.-W., Helmchen, F., & Lütcke, H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2240-15.2015 · Cited by 142 · see citing works
Forecasting psychosis by event-related potentials-systematic review and specific meta-analysis
Bodatsch, M., Brockhaus-Dumke, A., Klosterkötter, J., & Ruhrmann, S. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.025 · Cited by 135 · see citing works
Neural mechanisms of mismatch negativity dysfunction in schizophrenia
Lee, M., Sehatpour, P., Hoptman, M. J., Lakatos, P., Dias, E. C., Kantrowitz, J. T., Martı́nez, A., & Javitt, D. C. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.3 · Cited by 124 · see citing works
A Hierarchy of Responses to Auditory Regularities in the Macaque Brain
Uhrig, L., Dehaene, S., & Jarraya, B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3165-13.2014 · Cited by 123 · see citing works
The effects of ketamine on the mismatch negativity (MMN) in humans - A meta-analysis.
Rosburg, T., & Kreitschmann-Andermahr, I. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.10.062 · Cited by 123 · see citing works
Improvement in mismatch negativity generation during d-serine treatment in schizophrenia: Correlation with symptoms
Kantrowitz, J. T., Epstein, M. L., Lee, M., Lehrfeld, N., Nolan, K. A., Shope, C., Petkova, E., Silipo, G., & Javitt, D. C. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.027 · Cited by 123 · see citing works
Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy
Rosburg, T. (2005) · Brain · doi:10.1093/brain/awh442 · Cited by 121 · see citing works
Mismatch Negativity: Translating the Potential
Todd, J., Harms, L. R., Schall, U., & Michie, P. T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00171 · Cited by 118 · see citing works
The relationship between preattentive sensory processing deficits and age in schizophrenia patients
Michael Kiang, A., BRAFF, D. L., Sprock, J., & Light, G. A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.019 · Cited by 117 · see citing works
Event-Related Potential, Time-frequency, and Functional Connectivity Facets of Local and Global Auditory Novelty Processing: An Intracranial Study in Humans
El Karoui, I., King, J.-R., Sitt, J., Meyniel, F., Van Gaal, S., Hasboun, D., Adam, C., Navarro, V., Baulac, M., Dehaene, S., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu143 · Cited by 114 · see citing works
Mismatch Negativity as a “Translatable” Brain Marker Toward Early Intervention for Psychosis: A Review
Nagai, T., Tada, M., Kirihara, K., Araki, T., Jinde, S., & Kasai, K. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00115 · Cited by 114 · see citing works
Self-citation
Neuronal adaptation, novelty detection and regularity encoding in audition
Malmierca, M. S. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00111 · Cited by 113 · see citing works
Mismatch Negativity and Cognitive Performance for the Prediction of Psychosis in Subjects with At-Risk Mental State
Higuchi, Y., Sumiyoshi, T., Seo, T., Miyanishi, T., Kawasaki, Y., & Suzuki, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054080 · Cited by 110 · see citing works
Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice
Siegel, S. J., Connolly, P. M., Liang, Y., Lenox, R. H., Gur, R. E., Bilker, W. B., Kanes, S. J., & Turetsky, B. I. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300087 · Cited by 104 · see citing works
Memantine Effects On Sensorimotor Gating and Mismatch Negativity in Patients with Chronic Psychosis
Swerdlow, N. R., Bhakta, S. G., Chou, H., Talledo, J., Balvaneda, B., & Light, G. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.162 · Cited by 102 · see citing works
Auditory mismatch negativity and P3a in response to duration and frequency changes in the early stages of psychosis
Nagai, T., Tada, M., Kirihara, K., Yahata, N., Hashimoto, R., Araki, T., & Kasai, K. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.005 · Cited by 102 · see citing works
Self-citation
Differential Relationships of Mismatch Negativity and Visual P1 Deficits to Premorbid Characteristics and Functional Outcome in Schizophrenia
Friedman, T., Sehatpour, P., Dias, E., Perrin, M., & Javitt, D. C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.037 · Cited by 102 · see citing works
Frontal Glutamate and γ-Aminobutyric Acid Levels and Their Associations With Mismatch Negativity and Digit Sequencing Task Performance in Schizophrenia
Rowland, L. M., Summerfelt, A. T., Wijtenburg, S. A., Du, X. M., Chiappelli, J., Krishna, N., West, J., Muellerklein, F., Kochunov, P. V., & Hong, L. E. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2680 · Cited by 96 · see citing works
Pre-Attentive Auditory Processing in Ultra-High-Risk for Schizophrenia with Magnetoencephalography
Shin, K. S., Kim, J. S., Kang, D.-H., Koh, Y., Choi, J., O’Donnell, B. F., Chung, C. K., & Kwon, J. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.024 · Cited by 87 · see citing works
Rhesus Monkeys (Macaca mulatta) Sense Isochrony in Rhythm, but Not the Beat: Additional Support for the Gradual Audiomotor Evolution Hypothesis
Honing, H., Bouwer, F. L., Prado, L., & Merchant, H. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00475 · Cited by 86 · see citing works
Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia
Avissar, M., Xie, S., Vail, B., López‐Calderón, J., Wang, Y., & Javitt, D. C. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.009 · Cited by 81 · see citing works
Hierarchical Organization of Frontotemporal Networks for the Prediction of Stimuli across Multiple Dimensions
Phillips, H. N., Blenkmann, A. O., Hughes, L. E., Bekinschtein, T. A., & Rowe, J. B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5095-14.2015 · Cited by 80 · see citing works
Rodent Mismatch Negativity/theta Neuro-Oscillatory Response as a Translational Neurophysiological Biomarker for N-Methyl-D-Aspartate Receptor-Based New Treatment Development in Schizophrenia
Lee, M., Balla, A., Sershen, H. W., Sehatpour, P., Lakatos, P., & Javitt, D. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.176 · Cited by 78 · see citing works
Effects of NMDA receptor antagonist memantine on mismatch negativity
Korostenskaja, M., Nikulin, V. V., Kičić, D., Nikulina, A. V., & Kähkönen, S. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.01.007 · Cited by 77 · see citing works
Criteria for determining whether mismatch responses exist in animal models: Focus on rodents
Harms, L. R., Michie, P. T., & Näätänen, R. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.07.006 · Cited by 74 · see citing works
Auditory event-related potential of subjects with suspected pre-psychotic state and first‐episode psychosis
Hsieh, M. H., Shan, J., Huang, W., Cheng, W.-C., Chiu, M., Jaw, F., Hwu, H., & Liu, C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.021 · Cited by 72 · see citing works
Frontal and temporal sources of mismatch negativity in healthy controls, patients at onset of schizophrenia in adolescence and others at 15 years after onset
Oknina, L. B., Wild–Wall, N., Oades, R. D., Juran, S. A., Röpcke, B., Pfueller, U., Weisbrod, M., Chan, E., & Chen, E. Y. H. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.10.003 · Cited by 70 · see citing works
The effects of glycine on auditory mismatch negativity in schizophrenia
Greenwood, L., Leung, S., Michie, P. T., Green, A. E., Nathan, P. J., Fitzgerald, P. B., Johnston, P., Solowij, N., Kulkarni, J., & Croft, R. J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.05.031 · Cited by 69 · see citing works
Electrophysiological, cognitive and clinical profiles of at-risk mental state: The longitudinal Minds in Transition (MinT) study
Atkinson, R. J., Fulham, W. R., Michie, P. T., Ward, P. B., Todd, J., Stain, H. J., Langdon, R. A., Thienel, R., Paulik, G., Cooper, G. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171657 · Cited by 67 · see citing works
Abnormal intrinsic and extrinsic connectivity within the magnetic mismatch negativity brain network in schizophrenia: a preliminary study
Dima, D., Frangou, S., Burge, L., Braeutigam, S., & James, A. C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2011.12.024 · Cited by 65 · see citing works
Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia
Gaebler, A. J., Mathiak, K., Koten, J. W., König, A. A., Koush, Y., Weyer, D., Depner, C., Matentzoglu, S., Edgar, J. C., Willmes, K., et al. (2015) · Brain · doi:10.1093/brain/awv049 · Cited by 65 · see citing works
Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis
Nagai, T., Kirihara, K., Tada, M., Koshiyama, D., Koike, S., Suga, M., Araki, T., Hashimoto, K., & Kasai, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-02267-1 · Cited by 61 · see citing works
Self-citation
Mismatch Negativity But Not P300 Is Associated With Functional Disability in Schizophrenia
Hamilton, H., Perez, V. B., Ford, J. M., Roach, B. J., Jaeger, J., & Mathalon, D. H. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx104 · Cited by 58 · see citing works
Mismatch negativity in common marmosets: Whole-cortical recordings with multi-channel electrocorticograms
Komatsu, M., Takaura, K., & Fujii, N. (2015) · Scientific Reports · doi:10.1038/srep15006 · Cited by 57 · see citing works
Duration and frequency mismatch negativity shows no progressive reduction in early stages of psychosis
Koshiyama, D., Kirihara, K., Tada, M., Nagai, T., Koike, S., Suga, M., Araki, T., & Kasai, K. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.015 · Cited by 53 · see citing works
Self-citation
Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
Koshiyama, D., Kirihara, K., Tada, M., Nagai, T., Fujioka, M., Koike, S., Suga, M., Araki, T., & Kasai, K. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.09.045 · Cited by 50 · see citing works
Self-citation
Deviance detection is the dominant component of auditory contextual processing in the lateral superior temporal gyrus: A human ECoG study
Ishishita, Y., Kunii, N., Shimada, S., Ibayashi, K., Tada, M., Kirihara, K., Kawai, K., Uka, T., Kasai, K., & Saito, N. (2018) · Human Brain Mapping · doi:10.1002/hbm.24438 · Cited by 50 · see citing works
Self-citation
Mismatch Negativity and P3a/Reorienting Complex in Subjects with Schizophrenia or At-Risk Mental State
Higuchi, Y., Seo, T., Miyanishi, T., Kawasaki, Y., Suzuki, M., & Sumiyoshi, T. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00172 · Cited by 48 · see citing works
Auditory ERPs to Stimulus Deviance in an Awake Chimpanzee (Pan troglodytes): Towards Hominid Cognitive Neurosciences
Ueno, A., Hirata, S., Fuwa, K., Sugama, K., Kusunoki, K., Matsuda, G., Fukushima, H., Hiraki, K., Tomonaga, M., & Hasegawa, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001442 · Cited by 45 · see citing works
Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity
Kim, M., Lee, T. H., Yoon, Y. B., Lee, T. Y., & Kwon, J. S. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx102 · Cited by 45 · see citing works
Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis
Murphy, J. R., Rawdon, C., Kelleher, I., Twomey, D. M., Markey, P. S., Cannon, M. D., & Roche, R. A. P. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-45 · Cited by 44 · see citing works
Statistical context shapes stimulus-specific adaptation in human auditory cortex
Herrmann, B., Henry, M. J., Fromboluti, E. K., McAuley, J. D., & Obleser, J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00634.2014 · Cited by 43 · see citing works
Characteristic profiles of high gamma activity and blood oxygenation level-dependent responses in various language areas
Kunii, N., Kamada, K., Ota, T., Kawai, K., & Saito, N. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.059 · Cited by 42 · see citing works
Self-citation
Late deviance detection in rats is reduced, while early deviance detection is augmented by the NMDA receptor antagonist MK-801
Harms, L., Fulham, W. R., Todd, J., Meehan, C., Schall, U., Hodgson, D. M., & Michie, P. T. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.042 · Cited by 40 · see citing works
A tale of two sites: Differential impairment of frequency and duration mismatch negativity across a primarily inpatient versus a primarily outpatient site in schizophrenia
Lee, M., Sehatpour, P., Dias, E. C., Silipo, G. S., Kantrowitz, J. T., Martı́nez, A., & Javitt, D. C. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.032 · Cited by 40 · see citing works
Mismatch negativity impairment is associated with deficits in identifying real-world environmental sounds in schizophrenia
Joshi, Y. B., Breitenstein, B., Tarasenko, M. A., Thomas, M. L., Chang, W.-L., Sprock, J., Sharp, R. F., & Light, G. A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.05.020 · Cited by 40 · see citing works
Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis.
Solís-Vivanco, R., Mondragón-Maya, A., León-Ortíz, P., Rodríguez-Agudelo, Y., Cadenhead, K., & de la Fuente-Sandoval, C. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.009 · Cited by 38 · see citing works
No association between symptom severity and MMN impairment in schizophrenia: A meta-analytic approach
Erickson, M. A., Albrecht, M., Ruffle, A., Fleming, L., Corlett, P., & Gold, J. (2017) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2017.05.002 · Cited by 38 · see citing works
LORETA Current Source Density for Duration Mismatch Negativity and Neuropsychological Assessment in Early Schizophrenia
Miyanishi, T., Sumiyoshi, T., Higuchi, Y., Seo, T., & Suzuki, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061152 · Cited by 37 · see citing works
Impaired mismatch negativity to frequency deviants in individuals at ultra-high risk for psychosis, and preliminary evidence for further impairment with transition to psychosis
Lavoie, S., Jack, B. N., Griffiths, O., Ando, A., Amminger, G. P., Couroupis, A., Jago, A., Markulev, C., McGorry, P. D., Nelson, B., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.11.005 · Cited by 35 · see citing works
Parsing components of auditory predictive coding in schizophrenia using a roving standard mismatch negativity paradigm
McCleery, A., Mathalon, D. H., Wynn, J. K., Roach, B. J., Hellemann, G. S., Marder, S. R., & Green, M. F. (2019) · Psychological Medicine · doi:10.1017/s0033291718004087 · Cited by 35 · see citing works
Temporo-frontal phase synchronization supports hierarchical network for mismatch negativity
MacLean, S. E., & Ward, L. M. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.12.109 · Cited by 33 · see citing works
Peripheral Glutamate Levels in Schizophrenia: Evidence from a Meta-Analysis
Song, J., Viggiano, A., Monda, M., & Luca, V. D. (2014) · Neuropsychobiology · doi:10.1159/000364828 · Cited by 29 · see citing works
ERPs to pitch changes: a result of reduced responses to standard tones in rabbits.
Ruusuvirta, T., Korhonen, T., Arikoski, J., et al. (1996) · PubMed · Cited by 26 · see citing works
ERPs to pitch changes
Ruusuvirta, T., Korhonen, T., Arikoski, J., et al. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00009 · Cited by 26 · see citing works
The dynamics of language-related high-gamma activity assessed on a spatially-normalized brain
Kunii, N., Kamada, K., Ota, T., Greenblatt, R. E., Kawai, K., & Saito, N. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.06.006 · Cited by 25 · see citing works
Self-citation
Facilitative effect of repetitive presentation of one stimulus on cortical responses to other stimuli in macaque monkeys – a possible neural mechanism for mismatch negativity
Takaura, K., & Fujii, N. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13136 · Cited by 25 · see citing works
Tonal frequency affects amplitude but not topography of rhesus monkey cranial EEG components
Teichert, T. (2016) · Hearing Research · doi:10.1016/j.heares.2016.04.001 · Cited by 24 · see citing works
Dissociable auditory mismatch response and connectivity patterns in adolescents with schizophrenia and adolescents with bipolar disorder with psychosis: A magnetoencephalography study
Braeutigam, S., Dima, D., Frangou, S., & James, A. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.048 · Cited by 20 · see citing works
Magnetoencephalographic recording of auditory mismatch negativity in response to duration and frequency deviants in a single session in patients with schizophrenia
Suga, M., Nishimura, Y., Kawakubo, Y., Yumoto, M., & Kasai, K. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12397 · Cited by 17 · see citing works
Self-citation
Mapping phonemic processing zones along human perisylvian cortex: an electro-corticographic investigation
Molholm, S., Mercier, M. R., Liebenthal, E., Schwartz, T. H., Ritter, W., Foxe, J. J., & Sanctis, P. D. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0574-y · Cited by 10 · see citing works

Flagged first, then by citations

Research works printed but not linked: 4

Gross, G., Huber, G., Klosterkftter, J., Linz, M., 1987. Bonner Skala fqr die Beurteilung von Basissymptomen (BSABS; Bonn Scale for the Assessment of Basic Symptoms). Springer, Berlin.
Hamilton, H.K., Perez, V.B., Ford, J.M., Roach, B.J., Jaeger, J., Mathalon, D.H., 2018. Schizophr. Bull. 44 (3), 492-504.
Hsieh, M.H., Shan, J.C., Huang, W.L., Cheng, W.C., Chiu, M.J., Jaw, F.S., Hwu, H.G., Liu, C.C., 2012. Schizophr. Res. 140 (1-3), 243-249.
Swerdlow, N.R., Bhakta, S., Chou, H.H., Talledo, J.A., Balvaneda, B., Light, G.A., 2016. Neuropsychopharmacology 41 (2), 419-430.

Sorted by citations

A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia
Kirihara, K., Tada, M., Koshiyama, D., Fujioka, M., Usui, K., Araki, T., & Kasai, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00660 · Cited by 51 · see citing works
Self-citation
A neural mechanism underlying predictive visual motion processing in patients with schizophrenia
Scheliga, S., Schwank, R., Scholle, R., Habel, U., & Kellermann, T. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114934 · Cited by 8 · see citing works

Neurocognition and conversion to psychosis in adolescents at high-risk
Walder, D. J., Mittal, V. A., Trotman, H. D., McMillan, A. L., & Walker, E. F. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.12.477 · Cited by 40 · see citing works
32.4 EARLY TREATMENT ENGAGEMENT AMONG TRANSITION-AGE YOUTH WITH PSYCHOSIS: FINDINGS FROM AN EARLY PSYCHOSIS INTERVENTION PROGRAM
Kozloff, N. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2020.07.740
Importance of Early Detection in Early Psychosis
Joo, S. W. (2024) · Korean Journal of Schizophrenia Research · doi:10.16946/kjsr.2024.27.1.14
Book Review: Implementing Early Intervention in Psychosis: A Guide to Establishing Early Psychosis Services
Voineskos, G. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900713
Early Intervention for Psychosis: The Calgary Early Psychosis Treatment and Prevention Program
Addington, J., & Addington, D. E. (2001) · PsycEXTRA Dataset · doi:10.1037/e495602004-001 · Cited by 30 · see citing works

Authors: Tada, M., Kirihara, K., Mizutani, S., Uka, T., Kunii, N., Koshiyama, D., Fujioka, M., Usui, K., Nagai, T., Araki, T., & Kasai, K.
Affiliations: International Research Center for Neurointelligence, The University of Tokyo (JP)
The University of Tokyo (JP)
University of Yamanashi (JP)
University of Tokyo Hospital (JP)
Corresponding author: Kasai, Kiyoto
ORCID: Tada, Mariko
Kirihara, Kenji
Mizutani, Shunsuke
Uka, Takanori
Kunii, Naoto
Koshiyama, Daisuke
Fujioka, Mao
Usui, Kaori
Nagai, Tatsuya
Araki, Tsuyoshi
Kasai, Kiyoto
Venue: International Journal of Psychophysiology
Publisher: Elsevier BV
Published: 2019-11
Volume: 145
Pages: 5-14
ISSN: 0167-8760 (ISSN-L)
DOI: 10.1016/j.ijpsycho.2019.02.009
OpenAlex: W2919708535
Cited by: 74
References: 123
Citations by year: 2026: 5 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 13 · 2019: 2
FWCI: 1.64
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: International Journal of Psychophysiology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (15H06166, 18K07588)
Japan Agency for Medical Research and Development (JP17dm0207004)
University of Tokyo Institutes for Advanced Study
University of Tokyo Center for Integrative Science of Human Behavior
SENSHIN Medical Research Foundation
Takeda Science Foundation
Naito Foundation
Kurata Grants
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords: mismatch negativity, early psychosis, schizophrenia, deviance detection, predictive coding, neural adaptation, biomarkers, animal models of schizophrenia, non-human primates, rodent models, intracranial recordings, functional outcome
MeSH terms: Animals, Auditory Cortex, Auditory Perception, Disease Models, Animal, Electroencephalography, Evoked Potentials, Auditory, Humans, Psychotic Disorders, Schizophrenia, Translational Research, Biomedical

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