Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer
Abstract
Black phosphorus (BP) nanomaterials have attracted extensive attention due to their unique physical, chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging. They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer.
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BP has outstanding photothermal properties when exposed to NIR radiation, opening applications for cancer photoacoustic imaging and PTT.
“It is widely known that BP has outstanding photothermal properties when exposed to NIR radiation, which opens up a wide range of applications for it as smart nanoparticles for cancer photoacoustic (PA) imaging and PTT.120”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [120]
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Deng, L., Xu, Y., Sun, C., Yun, B., Sun, Q., Zhao, C., & Li, Z.
- Affiliations
- East China University of Science and Technology (CN)
- Soochow University (CN)
- Corresponding author
- Zhao, Chongjun
- Li, Zhen
- Venue
- Science Bulletin
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 63
- Issue
- 14
- Pages
- 917-924
- ISSN
- 2095-9273 (ISSN-L)
- OpenAlex
- W2803634211
- Cited by
- 104
- References
- 36
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 17 · 2023: 8 · 2022: 13 · 2021: 17 · 2020: 13 · 2019: 13 · 2018: 2
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- 中国科学通报:英文版 (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81471657, 81527901)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Materials Science › Materials Chemistry › Carbon and Quantum Dots Applications
- Keywords
- nanoparticle functionalization, dextran coating, poly(ethyleneimine), folic acid, targeted imaging, photoacoustic imaging, near-infrared fluorescence imaging, photothermal therapy, cancer nanotheranostics, near-infrared optical properties
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