One-pot solventless preparation of PEGylated black phosphorus nanoparticles for photoacoustic imaging and photothermal therapy of cancer
Abstract
Black phosphorus (BP) nanostructures such as nanosheets and nanoparticles have attracted considerable attention in recent years due to their unique properties and great potential in various physical, chemical, and biological fields. In this article, water-soluble and biocompatible PEGylated BP nanoparticles with a high yield were prepared by one-pot solventless high energy mechanical milling technique. The resultant BP nanoparticles can efficiently convert near infrared (NIR) light into heat, and exhibit excellent photostability, which makes them suitable as a novel nanotheranostic agent for photoacoustic (PA) imaging and photothermal therapy of cancer. The in-vitro results demonstrate the excellent biocompatibility of PEGylated BP nanoparticles, which can be used for photothermal ablation of cancer cells under irradiation with NIR light. The in-vivo PA images demonstrate that these BP nanoparticles can be efficiently accumulated in tumors through the enhanced permeability retention effect. The resultant BP nanoparticles can be further utilized for photothermal ablation of tumors by irradiation with NIR light. The tumor-bearing mice were completely recovered after photothermal treatment with BP nanoparticles, in comparison with mice from control groups. Our research highlights the great potential of PEGylated BP nanoparticles in detection and treatment of cancer.
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PEGylated BP nanoparticles prepared by solventless HEMM have homogeneous size, high biocompatibility, photostability, and capacity to generate heat from NIR light, making them appropriate as a novel nanotheranostic agent for PTT and PA imaging of cancer.
“The resulting PEGylated BP nanoparticles have a homogeneous size, high biocompatibility, photostability, and the capacity to generate heat from NIR light, making them appropriate as a novel nanotheranostic agent for photothermal therapy and PA imaging of cancer.121”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [121]
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Deng, L., Xu, Y., Sun, C., Yun, B., Sun, Q., Zhao, C., & Li, Z. (2018) · Science Bulletin · doi:10.1016/j.scib.2018.05.022 · Cited by 104 · see citing works
Self-citation
- Authors
- Sun, C., Wen, L., Zeng, J., Wang, Y., Sun, Q., Deng, L., Zhao, C., & Li, Z.
- Affiliations
- East China University of Science and Technology (CN)
- Soochow University (CN)
- Corresponding author
- Zhao, Chongjun
- Li, Zhen
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 91
- Pages
- 81-89
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2297431152
- Cited by
- 473
- References
- 57
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 44 · 2023: 29 · 2022: 53 · 2021: 53 · 2020: 68 · 2019: 71 · 2018: 63 · 2017: 40 · 2016: 8
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81471657, 81527901, 20504026)
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Shanghai Natural Science Foundation (13ZR1411900)
- Shanghai Leading Academic Discipline Project (B502)
- Shanghai Key Laboratory Project (08DZ2230500)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- PEGylation, high-energy ball milling, photoacoustic imaging, photothermal therapy, cancer theranostics, photostability, enhanced permeability and retention effect, tumor accumulation, biocompatibility, tumor ablation
- MeSH terms
- Animals, Breast, Breast Neoplasms, Female, Hyperthermia, Induced, Mice, Inbred BALB C, Phosphorus, Phototherapy, Polyethylene Glycols, Cell Line, Tumor, Mice, Nanoparticles, Photoacoustic Techniques
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