The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions
Abstract
During 2001, 76 water samples were collected upstream and downstream of select towns and cities in Iowa during high-, normal- and low-flow conditions to determine the contribution of urban centers to concentrations of pharmaceuticals and other organic wastewater contaminants (OWCs) in streams under varying flow conditions. The towns ranged in population from approximately 2000 to 200,000. Overall, one or more OWCs were detected in 98.7% of the samples collected, with 62 of the 105 compounds being found. The most frequently detected compounds were metolachlor (pesticide), cholesterol (plant and animal sterol), caffeine (stimulant), beta-sitosterol (plant sterol) and 1,7-dimethylxanthine (caffeine degradate). The number of OWCs detected decreased as streamflow increased from low- (51 compounds detected) to normal- (28) to high-flow (24) conditions. Antibiotics and other prescription drugs were only frequently detected during low-flow conditions. During low-flow conditions, 15 compounds (out of the 23) and ten compound groups (out of 11) detected in more than 10% of the streams sampled had significantly greater concentrations in samples collected downstream than in those collected upstream of the urban centers. Conversely, no significant differences in the concentrations were found during high-flow conditions. Thus, the urban contribution of OWCs to streams became progressively muted as streamflow increased.
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“Such observations are typical for effluent-dominated or -influenced streams during low-flow conditions.51−53”
From Sources and Pathways of PFAS Occurrence in Water Sources: Relative Contribution of Land-Applied Biosolids in an Agricultural Dominated Watershed (2025) · cites this paper as [52]
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Cites
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es011055j · Cited by 7,953
Self-citationPharmaceuticals and Personal Care Products in the Environment: Agents of Subtle Change?
Daughton, C. G., & Ternes, T. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s6907 · Cited by 4,703
Occurrence of drugs in German sewage treatment plants and rivers
Ternes, T. A. (1998) · Water Research · doi:10.1016/s0043-1354(98)00099-2 · Cited by 3,502
Occurrence, fate and effects of pharmaceutical substances in the environment- A review
Halling-Sørensen, B., Nors Nielsen, S., Lanzky, P. F., Ingerslev, F., Holten Lützhøft, H. C., & Jørgensen, S. E. (1998) · Chemosphere · doi:10.1016/s0045-6535(97)00354-8 · Cited by 3,285
Heberer, T. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(02)00041-3 · Cited by 2,995
Statistical Methods in Water Resources
Helsel, D. R., & Hirsch, R. M. (1992) · Studies in environmental science · doi:10.1016/s0166-1116(08)x7035-9 · Cited by 2,892
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es0201350 · Cited by 1,706
Self-citationRemoval of Pharmaceuticals during Drinking Water Treatment
Ternes, T. A., Meisenheimer, M., McDowell, D. C., Sacher, F., Brauch, H., Haist-Gulde, B., Preuß, G., Willme, U., & Zullei-Seibert, N. (2002) · Environmental Science & Technology · doi:10.1021/es015757k · Cited by 1,293
Silva, E., Rajapakse, N., & Kortenkamp, A. (2002) · Environmental Science & Technology · doi:10.1021/es0101227 · Cited by 914
Kuch, H., & Ballschmiter, K. (2001) · Environmental Science & Technology · doi:10.1021/es010034m · Cited by 740
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Nicholson, B. W. (2006) · Cited by 1
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Şen, F. (2019) · Materials research foundations · doi:10.21741/9781644900291-4 · Cited by 1
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Segura, P. A. (2009) · doi:10.71781/11863 · Cited by 1
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Watkins, C. (2012) · OakTrust (Texas A&M University Libraries) · Cited by 1
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Hantoosh, M. (2016) · UA Campus Repository (The University of Arizona) · Cited by 1
(2008) · Wiley eBooks · doi:10.1002/9780470369340.refs · Cited by 1
Sims, N. F., Holton, E., Archer, E., Botes, M., Wolfaardt, G. M., & Kasprzyk‐Hordern, B. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4189361 · Cited by 1
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Kullberg, A. T. (2018) · Digital Commons - Colby (Colby College)
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Alamino, D. A., & Silva, D. C. V. R. (2021) · doi:10.4322/978-65-86819-07-6-03
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Wijekoon, K. C. (2015) · Research Online (University of Wollongong)
Occurrences and impacts of pharmaceuticals and personal care products in soils and groundwater
Yang, Y., Zheng, Y., Huang, J., Zhang, Y., & Gao, B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824088-5.00006-9
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Naeem, S. S. (2018) · Advances in Pharmacology & Clinical Trials · doi:10.23880/apct-16000126
Sims, N. F., Holton, E., Archer, E., Botes, M., Wolfaardt, G. M., & Kasprzyk‐Hordern, B. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4104069
Prevalence and Impact of Emerging Chemical Contaminants in the Life Style Products on Human Health
Das, C. (2024) · Oriental Journal of Physical Sciences · doi:10.13005/ojps09.01.03
Biodiversity of macrobenthic fauna at Lake Taoura (Souk-Ahras, North East Algeria)
Benmalek, L., Bendali-Saoudi, F., Mahmoudi, K., & Soltani, N. (2024) · Brazilian Journal of Animal and Environmental Research · doi:10.34188/bjaerv7n4-116
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Verhagen, R., Veal, C., O'Malley, E., Gallen, M., Sturm, K., Bartkow, M., & Kaserzon, S. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgaf007
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Vallero, D. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-31446-9.00008-0
Paige, T., Taleski, D., Lu, J., Nguyen, H., BUDDHADASA, S. C., Nugegoda, D., & Pettigrove (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128360
Guo, Z., Lin, H. H., Yang, J.-S., & Lin, A. Y. (2026) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2026.110410
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Li, J., Guo, L., Wu, X., Sun, M., Xu, L., Xu, C., Kuang, H., & Xu, X. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c00568
Бекбергеновна, С. Г., Тураевич, К. Н., АКБАРОВ, Х., Aytmuratova, A., Usnatdinova, S., Mamatov, J., Otajonov, O., Muyassarova, R., & Tileubaev, S. (2026) · Voprosy Khimii i Khimicheskoi Tekhnologii · doi:10.32434/0321-4095-2026-167-4-30-42
Vallero, D. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44925-3.00008-9
Alula, G. A., Masindi, V., & Foteinis, S. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.124844
Li, K., Liu, J., Cheng, Y., Zhou, C., Shan, K., Peng, C., Yan, W., Liu, Y., Xu, A., & Zuo, M. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.143443
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Fent, K. (2006) · Springer eBooks · doi:10.1007/3-540-33638-9_8
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Metadata
- Authors
- KOLPIN, D., SKOPEC, M., MEYER, M., FURLONG, E., & ZAUGG, S.
- Affiliations
- United States Geological Survey (US)
- Iowa Geological Survey (US)
- Corresponding author
- KOLPIN, D
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2004-07-26
- Volume
- 328
- Issue
- 1-3
- Pages
- 119-130
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W1980686360
- Cited by
- 579
- References
- 40
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 15 · 2023: 12 · 2022: 20 · 2021: 31 · 2020: 30 · 2019: 19 · 2018: 32 · 2017: 20 · 2016: 34 · 2015: 26 · 2014: 37 · 2013: 35 · 2012: 35
- FWCI
- 31.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Geological Survey
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Environmental Engineering › Urban Stormwater Management Solutions
- Physical Sciences › Environmental Science › Water Science and Technology › Water Quality and Pollution Assessment
- Keywords
- pharmaceuticals, urban rivers, urban runoff, metolachlor, cholesterol, β-sitosterol, caffeine, 1,7-dimethylxanthine, antibiotics, prescription drugs, Iowa streams
- MeSH terms
- Chromatography, Liquid, Cities, Pharmaceutical Preparations, Environmental Monitoring, Iowa, Mass Spectrometry, Waste Disposal, Fluid, Rivers
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