The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
CDH2 and CDH11 act as regulators of stem cell fate decisions
Open accessAbstract
Accumulating evidence suggests that the mechanical and biochemical signals originating from cell-cell adhesion are critical for stem cell lineage specification. In this review, we focus on the role of cadherin mediated signaling in development and stem cell differentiation, with emphasis on two well-known cadherins, cadherin-2 (CDH2) (N-cadherin) and cadherin-11 (CDH11) (OB-cadherin). We summarize the existing knowledge regarding the role of CDH2 and CDH11 during development and differentiation in vivo and in vitro. We also discuss engineering strategies to control stem cell fate decisions by fine-tuning the extent of cell-cell adhesion through surface chemistry and microtopology. These studies may be greatly facilitated by novel strategies that enable monitoring of stem cell specification in real time. We expect that better understanding of how intercellular adhesion signaling affects lineage specification may impact biomaterial and scaffold design to control stem cell fate decisions in three-dimensional context with potential implications for tissue engineering and regenerative medicine.
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Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299
Myotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587
Myofibroblast development is characterized by specific cell-cell adherens junctions
Hinz, B., Pittet, P., Smith-Clerc, J., Chaponnier, C., & Meister, J.-J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0386 · Cited by 231
Role of N‐cadherin in bone formation
Marie, P. J. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10073 · Cited by 132
Cited by
Elmentaite, R., Ross, A. D. B., Roberts, K., James, K. R., Ortmann, D., Gomes, T., Nayak, K., Tuck, L., Pritchard, S., Bayraktar, O. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.11.010 · Cited by 316
Lodyga, M., Cambridge, E., Karvonen, H. M., Pakshir, P., Wu, B., Boo, S., Kiebalo, M., Kaarteenaho, R., Glogauer, M., Kapoor, M., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aao3469 · Cited by 181
Wan, H., Huang, X., Cong, P., He, M., Chen, A., Wu, T., Dai, D., Li, W., Gao, X., Tian, L., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.711239 · Cited by 33
Metadata
- Authors
- Alimperti, S., & Andreadis, S. T.
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 14
- Issue
- 3
- Pages
- 270-282
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W1967265511
- Cited by
- 166
- References
- 6
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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