Cerebrospinal fluid apolipoprotein E concentration decreases after seizure
Open accessAbstract
Purpose In epilepsy, many studies were focus on apoE gene polymorphism and found APOE epsilon4 to be associated with earlier onset of temporal lobe epilepsy. There is not any study about apoE in cerebrospinal fluid (CSF) of epileptic patients, so we detect the CSF-apoE and determine whether it is changed after seizure. Methods A total of 60 epileptic patients and 28 subjects with no evidence of any neurological diseases were studied. The concentrations of CSF-apoE were detected with enzyme-linked immunosorbent assay. Results The CSF-apoE levels in epilepsy and control group were 5.78+/-2.15 mg/l and 13.60+/-12.11 mg/l, and there were statistical difference. In epilepsy group, the CSF-apoE concentration was 6.53+/-2.55 mg/l in male patients, and 4.98+/-1.21 mg/l in female. In secondary epilepsy group was 5.06+/-1.31 mg/l, and in idiopathic epilepsy was 6.04+/-2.34 mg/l. In different seizure types groups, including complex partial seizure (CPS), secondarily generalized tonic-clonic seizure (SGTC), generalized tonic-clonic seizure (GTCS), and absence seizure (AS), the mean concentrations of CSF-apoE were 6.62+/-3.13 mg/l, 5.21+/-1.22 mg/l, 5.00+/-1.09 mg/l and 7.25+/-1.88 mg/l, respectively. Conclusions CSF-apoE concentration decreases after seizures, correlated with the gender, etiological factor and seizure types.
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The concentration 0.375 M is similar to the reported concentration of apoE in human cerebrospinal fluid (0.365-0.395 M).
“More importantly, toxicity (28% decrease in cell viability) was evident even when lipidated apoE4[L28P] was used at the lower concentration of 0.375 M, which is similar to the reported concentration of apoE in human cerebrospinal fluid (0.365-0.395M) (47,48).”
From Molecular Basis for Increased Risk for Late-onset Alzheimer Disease Due to the Naturally Occurring L28P Mutation in Apolipoprotein E4 (2014) · cites this paper as [48]
The Results report apoE in control subjects’ cerebrospinal fluid at 13.60 ± 12.11 mg/L, and the Introduction gives apoE’s molecular mass as 32 kDa. That mean converts to approximately 0.425 µM, broadly comparable to 0.375 µM, but the paper does not report the claimed 0.365–0.395 µM range. If the citing sentence’s printed unit “M” is literal rather than an omitted micro symbol, the concentrations are not comparable. (LLM, conf=0.86)
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- Authors
- Wang, L., Han, Y., Chen, D., Xiao, Z., Xi, Z., Xiao, F., & Wang, X.
- Affiliations
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Corresponding author
- Wang, Xuefeng
- Venue
- Seizure
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 19
- Issue
- 2
- Pages
- 79-83
- ISSN
- 1059-1311 (ISSN-L)
- OpenAlex
- W2038533852
- Cited by
- 23
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2021: 3 · 2016: 2 · 2014: 7 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Seizure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- apolipoprotein E, cerebrospinal fluid, epilepsy, seizures, seizure types, complex partial seizures, generalized tonic-clonic seizures, symptomatic epilepsy, idiopathic epilepsy, sex differences, APOE ε4
- MeSH terms
- Adolescent, Adult, Apolipoproteins E, Child, Female, Humans, Male, Middle Aged, Seizures, Sex Factors, Young Adult
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