DNA replication fidelity and cancer

Comprehensive Analysis of DNA Repair Gene Variants and Risk of Meningioma

Bethke, L., Murray, A., Webb, E. L., Schoemaker, M. J., Muir, K. R., McKinney, P. A., Hepworth, S. J., Dimitropoulou, P., Lophatananon, A., Feychting, M., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn004 · Cited by 64

DNA polymerase ɛ is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts

Shou, W.-G., Masuda, T., Takisawa, H., & Sugino, A. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.081088798 · Cited by 60

Mutations affecting a putative MutLα endonuclease motif impact multiple mismatch repair functions

Erdeniz, N., Nguyen, M. M., Deschênes, S. M., & Liskay, R. M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.04.013 · Cited by 59

Exonucleolytic proofreading of leading and lagging strand DNA replication errors.

Roberts, J. D., Thomas, D. C., & Kunkel, T. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3465 · Cited by 57

Reduced Levels of DNA Polymerase δ Induce Chromosome Fragile Site Instability in Yeast

Lemoine, F. J., Degtyareva, N. P., Kokoska, R. J., & Petes, T. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02084-07 · Cited by 54

Genetic interaction between HAP1/REF-1 and p53

Meira, L. B., Cheo, D. L., Hammer, R. E., Burns, D. K., Reis, A., & Friedberg, E. C. (1997) · Nature Genetics · doi:10.1038/ng1097-145 · Cited by 53

Genetic Factors Affecting the Impact of DNA Polymerase ∂ Proofreading Activity on Mutation Avoidance in Yeast

Tran, H. T., Degtyareva, N. P., Gordenin, D. A., & Resnick, M. A. (1999) · Genetics · doi:10.1093/genetics/152.1.47 · Cited by 51

A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replication

Pospiech, H. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.19.3799 · Cited by 47

Evidence for Extrinsic Exonucleolytic Proofreading

McElhinny, S. A. N., Pavlov, Y. I., & Kunkel, T. A. (2006) · Cell Cycle · doi:10.4161/cc.5.9.2736 · Cited by 47

Spontaneous Frameshift Mutations in Saccharomyces cerevisiae: Accumulation During DNA Replication and Removal by Proofreading and Mismatch Repair Activities

Greene, C. N., & Jinks-Robertson, S. (2001) · Genetics · doi:10.1093/genetics/159.1.65 · Cited by 45

Alterations of DNA and Chromatin Structures at Telomeres and Genetic Instability in Mouse Cells Defective in DNA Polymerase α

Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F., & Ishikawa, F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11073-11088.2005 · Cited by 44

Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts

Andrew, S. E., Xu, X., Baross, Á., Narayanan, L., Milhausen, K., Liskay, R. M., Jirik, F. R., & Glazer, P. M. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.291 · Cited by 44

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations

Pavlov, Y. I., Maki, S., Maki, H., & Kunkel, T. A. (2004) · BMC Biology · doi:10.1186/1741-7007-2-11 · Cited by 41

Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer

Meira, L. B., Cheo, D. L., Reis, A., Claij, N., Burns, D. K., Riele, H. T., & Friedberg, E. C. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00143-x · Cited by 41

Lynch Syndrome and Related Familial Colorectal Cancers

Abdel‐Rahman, W. M., & Peltomäki, P. (2008) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v14.i1.10 · Cited by 40

Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions

Meira, L. B., Reis, A., Cheo, D. L., Nahari, D., Burns, D. K., & Friedberg, E. C. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00097-5 · Cited by 35

Elevated mutant frequencies and increased C : G→T : A transitions in Mlh1−/− versus Pms2−/− murine small intestinal epithelial cells

Baross, Á., Makhani, N., Liskay, R. M., & Jirik, F. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204138 · Cited by 35

Loss of Heterozygosity and Base Substitution at the APRT Locus in Mismatch-Repair-Proficient and -Deficient Colorectal Carcinoma Cell Lines

Phear, G. A., Bhattacharyya, N. P., & Meuth, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6516 · Cited by 34

Schizosacchromyces pombeDpb2 Binds to Origin DNA Early in S Phase and Is Required for Chromosomal DNA Replication

Feng, W., Rodriguez-Menocal, L., Tolun, G., & D’Urso, G. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-02-0088 · Cited by 33

Fidelity of DNA synthesis in a mammalian in vitro replication system.

Hauser, J. M., Levine, A. S., & Dixon, K. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3267 · Cited by 31

Distinctive activities of DNA polymerases during human DNA replication

Rytkönen, A. K., Vaara, M., Nethanel, T., Kaufmann, G., Sormunen, R. T., Läärä, E., Nasheuer, H., Rahmeh, A. A., Lee, M., Syväoja, J. E., et al. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05310.x · Cited by 29

Random mutations, selected mutations: A PIN opens the door to new genetic landscapes

Klein, C. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609000103 · Cited by 29

Low Levels of DNA Polymerase Alpha Induce Mitotic and Meiotic Instability in the Ribosomal DNA Gene Cluster of Saccharomyces cerevisiae

Casper, A. M., Mieczkowski, P. A., Gaweł, M., & Petes, T. D. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000105 · Cited by 27

Proofreading Activity of DNA Polymerase Pol2 Mediates 3′-End Processing during Nonhomologous End Joining in Yeast

Tseng, S., Gabriel, A., & Teng, S. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000060 · Cited by 25

DNA Replication Fidelity: Proofreading in Trans

Albertson, T., & Preston, B. D. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.031 · Cited by 23

Case Series

Treuting, P. M., Albertson, T., & Preston, B. D. (2010) · Toxicologic Pathology · doi:10.1177/0192623310362249 · Cited by 21

DNA polymerase δ-dependent repair of DNA single strand breaks containing 3′-end proximal lesions

Parsons, J. L., Preston, B. D., O'Connor, T. R., & Dianov, G. L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1115 · Cited by 21

Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk

Monsees, G. M., Kraft, P., Chanock, S. J., Hunter, D. J., & Han, J. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0947-3 · Cited by 19

Stationary-phase mutations in proofreading exonuclease-deficient strains of the yeast Saccharomyces cerevisiae

Babudri, N., Pavlov, Y. I., Matmati, N., Ludovisi, C., & Achili, A. (2001) · Molecular Genetics and Genomics · doi:10.1007/s004380000424 · Cited by 19

Base Excision Repair

Meira, L. B., Burgis, N. E., & Samson, L. D. (2006) · Springer eBooks · doi:10.1007/1-4020-3764-3_5 · Cited by 17

Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer.

Zhou, Q., Effati, R., Talvinen, K., Pospiech, H., Syväoja, J. E., & Collan, Y. U. (2008) · PubMed · Cited by 16

Preferential inhibition of DNA polymerases?,?, and? from Novikoff hepatoma cells by inhibitors of cell proliferation

Fox, G., Popanda, O., Edler, L., & Thielmann, H. W. (1996) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01226265 · Cited by 15

A mutation detected in DNA polymerase δ cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme

Popanda, O., Flohr, T., Fox, G., & Thielmann, H. W. (1999) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050322 · Cited by 12

Erratum to: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations

Pavlov, Y. I., Maki, S., Maki, H., & Kunkel, T. A. (2007) · BMC Biology · doi:10.1186/1741-7007-5-27 · Cited by 11

DNA polymerases ?, ?, and ? of Novikoff hepatoma cells differ from those of normal rat liver in physicochemical and catalytic properties

Popanda, O., Fox, G., & Thielmann, H. W. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00189927 · Cited by 8

Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer.

Zhou, Q., Talvinen, K., Sundström, J. T. T., Elzagheid, A., Pospiech, H., Syväoja, J. E., & Collan, Y. U. (2009) · PubMed · Cited by 7

The Unstable Path To Cancer

Kiberstis, P. A., & Marx, J. L. (2002) · Science · doi:10.1126/science.297.5581.543 · Cited by 5

Evidence for reduced copying fidelity of DNA polymerases α, δ, and ε from Novikoff hepatoma cells

Fox, G., Popanda, O., & Thielmann, H. W. (1997) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050121 · Cited by 4

Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.

Zhou, Q., Lehtonen, T., Lehtonen, J., Laakso, S., Szymaś, J., Pospiech, H., Huoponen, K., Syväoja, J. E., & Collan, Y. U. (2010) · PubMed · Cited by 2

DNA polymerases α, σ and ε of Novikoff hepatoma cells deviate from those of normal rat liver in physico-chemical and catalytic properties

Popanda, O., Fox, G., & Thielmann, H. W. (1995) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf02572030 · Cited by 1

Rapid screening for psychologic distress in men with prostate carcinoma

Roth, A. J., Kornblith, A. B., Batel-Copel, L., Peabody, E., Scher, H. I., & Holland, J. C. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980515)82:10

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

Wang, Y., Waters, J., Leung, M. L., Unruh, A., Roh, W., Shi, X., Chen, K., Scheet, P., Vattathil, S., Liang, H., et al. (2014) · Nature · doi:10.1038/nature13600 · Cited by 1,029

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Palles, C., Cazier, J., Howarth, K. M., Domingo, E., Jones, A. M., Broderick, P., Kemp, Z., Spain, S. L., Guarino, E., Salguero, I., et al. (2012) · Nature Genetics · doi:10.1038/ng.2503 · Cited by 1,008

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

Smith, M. T., Guyton, K., Gibbons, C., Fritz, J. M., Portier, C., Rusyn, I., DeMarini, D., Caldwell, J., Kavlock, R., Lambert, P., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509912 · Cited by 599

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

Griendling, K. K., Touyz, R. M., Zweier, J. L., Dikalov, S., Chilian, W. M., Chen, Y., Harrison, D. G., & Bhatnagar, A. (2016) · Circulation Research · doi:10.1161/res.0000000000000110 · Cited by 470

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes

Kim, T., Laird, P. W., & Park, P. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.015 · Cited by 387

DNA‐replication Fidelity, Mismatch Repair and Genome Instability in Cancer Cells

Umar, A., & Kunkel, T. A. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0297z.x · Cited by 207

The role of replication fidelity in mutator phenotypes and carcinogenesis.

Singh, M. (2012) · J. Willard Marriott Library · doi:10.26053/0h-er5q-gj00

Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

Blumenfeld, B., Ben‐Zimra, M., & Simon, I. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061138 · Cited by 41

Aberrant DNA replication in cancer

Suzuki, M., & Takahashi, T. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.07.003 · Cited by 32

Genetic systems for stability of DNA.

Sekiguchi, M. (1997) · Seibutsu Butsuri · doi:10.2142/biophys.37.100