Cited by 163DNA Repair MechanismsCancer-related Molecular PathwaysGenetic factors in colorectal cancer

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DNA replication fidelity and cancer

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Preston, Bradley D., Albertson, Tina M., Herr, Alan J.·2010·Seminars in Cancer Biology

DOI 10.1016/j.semcancer.2010.10.009PMC PMC2993855

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Abstract

Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

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The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
DNA Repair and Mutagenesis
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 3×
“[14].”
Background
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,884
Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456
Genomic instability — an evolving hallmark of cancer
Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271
Hereditary Colorectal Cancer
Lynch, H. T., & de la Chapelle, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra012242 · Cited by 2,240
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050
Genetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995
Lynch Syndrome Patients with Limited Family History Identified in a Laboratory Setting: A Descriptive Study
Landon, M., Saam, J. R., Brown, K. L., Moyes, K., Evans, B. A., & WENSTRUP, R. J. (2015) · Oncology · doi:10.1159/000430097 · Cited by 1,943
Rates of spontaneous mutation
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Mutation of a mutL Homolog in Hereditary Colon Cancer
Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,822
The Biology of Cancer
Weinberg, R. A., & Weinberg, R. A. (2006) · W.W. Norton eBooks · doi:10.1201/9780203852569 · Cited by 1,806
A comprehensive catalogue of somatic mutations from a human cancer genome
Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696
Mechanisms and functions of DNA mismatch repair
Li, G. (2007) · Cell Research · doi:10.1038/cr.2007.115 · Cited by 1,479
The impact of translocations and gene fusions on cancer causation
Mitelman, F., Johansson, B., & Mertens, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2091 · Cited by 1,400
The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,375
DNA MISMATCH REPAIR
Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,372
Hereditary and Familial Colon Cancer
Jasperson, K. W., Tuohy, T. M. F., Neklason, D. W., & Burt, R. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.054 · Cited by 1,370
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,144
Endogenous DNA damage in humans: a review of quantitative data
Bont, R. D. (2004) · Mutagenesis · doi:10.1093/mutage/geh025 · Cited by 1,099
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
Strand, M. K., Prolla, T. A., Liskay, R. M., & Petes, T. D. (1993) · Nature · doi:10.1038/365274a0 · Cited by 1,090
Transcription-coupled DNA repair: two decades of progress and surprises
Hanawalt, P. C., & Spivak, G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2549 · Cited by 1,081
A small-cell lung cancer genome with complex signatures of tobacco exposure
Pleasance, E., Stephens, P. J., O’Meara, S., McBride, D. J., Meynert, A. M., Jones, D., Lin, M., Beare, D. M., Lau, K. W., Greenman, C., et al. (2009) · Nature · doi:10.1038/nature08629 · Cited by 1,076
Hypermutability and mismatch repair deficiency in RER+ tumor cells
Parsons, R. E., Li, G., Longley, M. J., Fang, W.-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., & Modrich, P. L. (1993) · Cell · doi:10.1016/0092-8674(93)90331-j · Cited by 1,054
DNA Replication Fidelity
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003
Rules for Making Human Tumor Cells
Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2005) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 935
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
Lynch, H. T., Lynch, P. M., Lanspa, S. J., Snyder, C., Lynch, J. F., & Boland, C. R. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01230.x · Cited by 864
Eukaryotic DNA mismatch repair
Kolodner, R. D., & Marsischky, G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80013-6 · Cited by 861
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., & Barnes, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13300 · Cited by 807
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
de Wind, N., Dekker, M., Berns, A. J. M., Radman, M., & Riele, H. T. (1995) · Cell · doi:10.1016/0092-8674(95)90319-4 · Cited by 780
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753
Genetic instability and darwinian selection in tumours
Cahill, D. P., Kinzler, K. W., Vogelstein, B., & Lengauer, C. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01661-x · Cited by 747
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
Miyaki, M., Konishi, M., Tanaka, K., Kikuchi‐Yanoshita, R., Muraoka, M., Yasuno, M., Igari, T., Koike, M., Chiba, M., & Mori, T. (1997) · Nature Genetics · doi:10.1038/ng1197-271 · Cited by 720
Repair of Endogenous DNA Damage
LINDAHL, T., & BARNES, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.127 · Cited by 714
The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
Michaels, M. L., & Miller, J. H. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.20.6321-6325.1992 · Cited by 697
Eukaryotic DNA Polymerases
Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691
Genetic predisposition to colorectal cancer
de la Chapelle, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1453 · Cited by 670
Endonucleolytic Function of MutLα in Human Mismatch Repair
Kadyrov, F. A., Dzantiev, L., Constantin, N., & Modrich, P. L. (2006) · Cell · doi:10.1016/j.cell.2006.05.039 · Cited by 626
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis
Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A., Liskay, R. M., & Kunkel, T. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81323-9 · Cited by 577
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
McCulloch, S. D., & Kunkel, T. A. (2008) · Cell Research · doi:10.1038/cr.2008.4 · Cited by 569
Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication
Pursell, Z. F., Isoz, I., Lundström, E.-B., Johansson, E., & Kunkel, T. A. (2007) · Science · doi:10.1126/science.1144067 · Cited by 565
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
Acharya, S., Wilson, T., Gradia, S., Kane, M., Guerrette, S., Marsischky, G., Kolodner, R. D., & Fishel, R. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13629 · Cited by 534
Division of Labor at the Eukaryotic Replication Fork
McElhinny, S. A. N., Gordenin, D. A., Stith, C. M. W., Burgers, P., & Kunkel, T. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.022 · Cited by 528
Errors in DNA replication as a basis of malignant changes.
Loeb, L. A., Springgate, C. F., & Battula, N. (1974) · PubMed · Cited by 521
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
Lee, W., Jiang, Z., Liu, J., Haverty, P. M., Guan, Y., Stinson, J., Yue, P., Zhang, Y., Pant, K. P., Bhatt, D., et al. (2010) · Nature · doi:10.1038/nature09004 · Cited by 492
Maintenance of Genome Stability in Saccharomyces cerevisiae
Kolodner, R. D., Putnam, C. D., & Myung, K. (2002) · Science · doi:10.1126/science.1075277 · Cited by 470
DNA mismatch repair: Molecular mechanism, cancer, and ageing
Hsieh, P., & Yamane, K. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.012 · Cited by 463
Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred.
Akiyama, Y., Sato, H., Yamada, T., Nagasaki, H., Tsuchiya, A., Abe, R., & Yuasa, Y. (1997) · PubMed · Cited by 463
The Biochemistry of Somatic Hypermutation
Peled, J. U., Kuang, F. L., Iglesias-Ussel, M. D., Roa, S., Kalis, S. L., Goodman, M. F., & Scharff, M. D. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090236 · Cited by 460
Biochemical Basis of DNA Replication Fidelity
Goodman, M. F., Creighton, S., Bloom, L. B., Petruska, J., & Kunkel, T. A. (1993) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239309086792 · Cited by 446 · cited 2×
“1; reviewed in [53–71]).”
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
Kat, A. G., Thilly, W. G., Fang, W.-H., Longley, M. J., Li, G., & Modrich, P. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6424 · Cited by 443
Mutations Associated with HNPCC Predisposition — Update of ICG‐HNPCC/INSiGHT Mutation Database
Peltomäki, P., & Vasen, H. F. A. (2004) · Disease Markers · doi:10.1155/2004/305058 · Cited by 442
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics
Imai, K., & Yamamoto, H. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm228 · Cited by 433
Repeat instability as the basis for human diseases and as a potential target for therapy
López Castel, A., Cleary, J. D., & Pearson, C. E. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2854 · Cited by 429
Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
Cleaver, J. E., Lam, E. T., & Revet, I. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2663 · Cited by 428 · cited 2×
“[PubMed: 11927276] [24].”
Background
Mutator phenotypes in human colorectal carcinoma cell lines.
Bhattacharyya, N. P., Skandalis, A., Ganesh, A. N., Groden, J. L., & Meuth, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6319 · Cited by 424
Mitelman Database (Chromosome Aberrations and Gene Fusions in Cancer)
Griffith, M., & Griffith, O. L. (2004) · Dictionary of Bioinformatics and Computational Biology · doi:10.1002/9780471650126.dob0996 · Cited by 420
Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα
Genschel, J., Littman, S. J., Drummond, J. T., & Modrich, P. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19895 · Cited by 419
Familial endometrial cancer in female carriers of MSH6 germline mutations
Wijnen, J., de Leeuw, W. J. F., Vasen, H. F. A., van der Klift, H. M., Møller, P., Stormorken, A. T., Meijers-Heijboer, H. E. J., Lindhout, D., Menko, F. H., Vossen, S., et al. (1999) · Nature Genetics · doi:10.1038/13773 · Cited by 415
Genetic Progression and the Waiting Time to Cancer
Beerenwinkel, N., Tibor Antal, A., Dingli, D., Traulsen, A., Kinzler, K. W., Velculescu, V. E., Vogelstein, B., & Nowak, M. A. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030225 · Cited by 413
DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint
Navas, T. A., Zhou, Z. Y., & Elledge, S. J. (1995) · Cell · doi:10.1016/0092-8674(95)90448-4 · Cited by 403
Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability.
Duval, A., & Hamelin, R. (2002) · PubMed · Cited by 398
Mismatch repair and DNA damage signalling
Stojic, L., Brun, R., & Jiricny, J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.006 · Cited by 396
Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers
Baglietto, L., Lindor, N. M., Dowty, J. G., White, D. M., Wagner, A., Gómez-García, E. B., Vriends, A. H. J. T., Dutch Lynch Syndrome Study Group, Cartwright, N., Barnetson, R. A., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp473 · Cited by 375
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeastPreprint
Takayama, Y., Kamimura, Y., Okawa, M., Muramatsu, S., Sugino, A., & Araki, H. (2003) · Genes & Development · doi:10.1101/gad.1065903 · Cited by 372
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
Branch, P., Aquilina, G., Bignami, M., & Karran, P. (1993) · Nature · doi:10.1038/362652a0 · Cited by 364
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair
Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J., Yao, X., Bronner, C. E., Zheng, B., Gordon, M. D., Reneker, J., Arnheim, N., et al. (1998) · Nature Genetics · doi:10.1038/ng0398-276 · Cited by 363
Human cancers express a mutator phenotype
Bielas, J. H., Loeb, K. R., Rubin, B. P., True, L. D., & Loeb, L. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607057103 · Cited by 354
Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
Minowa, O., Arai, T., Hirano, M., Monden, Y., Nakai, S., Fukuda, M., Itoh, M., Takano, H., Hippou, Y., Aburatani, H., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050404497 · Cited by 348
BACTERIAL MUTATOR GENES AND THE CONTROL OF SPONTANEOUS MUTATION
Cox, E. C. (1976) · Annual Review of Genetics · doi:10.1146/annurev.ge.10.120176.001031 · Cited by 340
Polymerase Dynamics at the Eukaryotic DNA Replication Fork
Burgers, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800062200 · Cited by 338
Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli
Tajiri, T., Maki, H., & Sekiguchi, M. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)00062-b · Cited by 337
DNA polymerases and human disease
Loeb, L. A., & Monnat, R. J. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2345 · Cited by 330
Germ-line msh6 mutations in colorectal cancer families.
Kolodner, R. D., Tytell, J. D., Schmeits, J. L., Kane, M., Gupta, R. D., Weger, J., Wahlberg, S., Fox, E. A., Peel, D. A., Ziogas, A., et al. (1999) · PubMed · Cited by 324
DNA precursor metabolism and genomic stability
Mathews, C. K. (2006) · The FASEB Journal · doi:10.1096/fj.06-5730rev · Cited by 311
Chromosomal Translocations in Yeast Induced by Low Levels of DNA Polymerase
Lemoine, F. J., Degtyareva, N. P., Lobachev, K. S., & Petes, T. D. (2005) · Cell · doi:10.1016/j.cell.2004.12.039 · Cited by 306
Hypermutability of Homonucleotide Runs in Mismatch Repair and DNA Polymerase Proofreading Yeast Mutants
Tran, H. T., Keen, J. D., Kricker, M., Resnick, M. A., & Gordenin, D. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2859 · Cited by 306
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
Parsons, R. E., Li, G., Longley, M. J., Modrich, P. L., Liu, B., Berk, T., Hamilton, S. R., Kinzler, K. W., & Vogelstein, B. (1995) · Science · doi:10.1126/science.7632227 · Cited by 305
Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.
Schaaper, R. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80446-3 · Cited by 305
Dividing the workload at a eukaryotic replication fork
Kunkel, T., & Burgers, P. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.005 · Cited by 294
The 3′–5′ exonucleases
Shevelev, I. V., & Hübscher, U. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm804 · Cited by 292
Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors
Xie, Y., Yang, H., Cunanan, C., Okamoto, K., Shibata, D., Pan, J., Barnes, D. E., Lindahl, T., McIlhatton, M., Fishel, R., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3834 · Cited by 291
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase
Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K. D., Ide, F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191086798 · Cited by 288
ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts
Yoshioka, K.-I., Yoshioka, Y., & Hsieh, P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.023 · Cited by 288
DNA Polymerase ε Catalytic Domains Are Dispensable for DNA Replication, DNA Repair, and Cell Viability
Kesti, T., Flick, K. M., Keränen, S., Syväoja, J. E., & Wittenberg, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80361-5 · Cited by 276
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.
Morrison, A., Bell, J. B., Kunkel, T. A., & Sugino, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9473 · Cited by 276
Bladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle–Control Genes
Wu, X., Gu, J. H., Grossman, H. B., Amos, C. I., Etzel, C. J., Huang, M., Zhang, Q. H., Millikan, R. E., Lerner, S., Dinney, C. P., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/500848 · Cited by 273
Mutational Heterogeneity in Human Cancers: Origin and Consequences
Salk, J. J., Fox, E., & Loeb, L. A. (2009) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102113 · Cited by 266
Pathway correcting DNA replication errors in Saccharomyces cerevisiae.
Morrison, A., Johnson, A. L., Johnston, L. H., & Sugino, A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05790.x · Cited by 264
SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair
Miller, J. H. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.625 · Cited by 259
Mouse Models of Colon Cancer
Taketo, M. M., & Edelmann, W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.049 · Cited by 257
Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
Aparicio, O. M., Stout, A. M., & Bell, S. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9130 · Cited by 247
Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
Tlsty, T. D., Margolin, B. H., & Lum, K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9441 · Cited by 246
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Eshleman, J. R., Lang, E. Z., Bowerfind, G. K., Parsons, R. E., Vogelstein, B., Willson, J. K. V., Veigl, M. L., Sedwick, W. D., & Markowitz, S. D. (1995) · PubMed · Cited by 242
Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion
Hicks, W. M., Kim, M., & Haber, J. E. (2010) · Science · doi:10.1126/science.1191125 · Cited by 240
DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice
Albertson, T., Ogawa, M., Bugni, J. M., Hays, L. E., Chen, Y., Wang, Y., Treuting, P. M., Heddle, J. A., Goldsby, R. E., & Preston, B. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907147106 · Cited by 239
Self-citation
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
Sakumi, K., Tominaga, Y., Furuichi, M., Xu, P., Tsuzuki, T., Sekiguchi, M., & Nakabeppu, Y. (2003) · PubMed · Cited by 237
Oxidative nucleotide damage: consequences and prevention
Sekiguchi, M., & Tsuzuki, T. (2002) · Oncogene · doi:10.1038/sj.onc.1206023 · Cited by 231
Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
Kunz, B. A., Kohalmi, S. E., Kunkel, T. A., Mathews, C. K., McIntosh, E. M., & Reidy, J. A. (1994) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(94)90006-x · Cited by 229
The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool
Colussi, C., Parlanti, E., Degan, P., Aquilina, G., Barnes, D., Macpherson, P., Karran, P., Crescenzi, M., Eugenia Dogliotti, Y., & Bignami, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00863-1 · Cited by 228
The 3′ to 5′ exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.
Simon, M., Giot, L., & Faye, G. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07751.x · Cited by 228
Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes
Clark, A., Valle, F., Drotschmann, K., Gary, R. K., & Kunkel, T. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000513200 · Cited by 227
Mechanisms of tolerance to DNA damaging therapeutic drugs
Karran, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.12.1931 · Cited by 226
Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.
Boulet, A., Simon, M., Faye, G., Bauer, G. A., & Burgers, P. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03580.x · Cited by 226
MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae
Ni, T. T., Marsischky, G., & Kolodner, R. D. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80346-9 · Cited by 222
Cancers Exhibit a Mutator Phenotype: Clinical Implications
Loeb, L. A., Bielas, J. H., & Beckman, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5835 · Cited by 220
The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells
Meuth, M. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90090-6 · Cited by 219
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
de Wind, N., Dekker, M., Claij, N., Jansen, L. A. M., van Klink, Y., Radman, M., Riggins, G., van der Valk, M., Wout, K. V. '., & Riele, H. T. (1999) · Nature Genetics · doi:10.1038/15544 · Cited by 215
Evolving Views of DNA Replication (In)FidelityPreprint
Kunkel, T. A. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.027 · Cited by 206
The 3′ → 5′ exonucleases of both DNA polymerases δ and ε participate in correcting errors of DNA replication in Saccharomyces cerevisiae
Morrison, A., & Sugino, A. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00280418 · Cited by 205
Human DNA polymerase α: predicted functional domains and relationships with viral DNA polymerases
Wang, T. S., Wong, S. W., & Korn, D. A. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.1.2642867 · Cited by 203
Signalling cell cycle arrest and cell death through the MMR System
O’Brien, V., & Brown, R. E. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi298 · Cited by 203
The 3′→5′ Exonucleases of DNA Polymerases δ and ɛ and the 5′→3′ Exonuclease Exo1 Have Major Roles in Postreplication Mutation Avoidance in Saccharomyces cerevisiae
Tran, H. T., Gordenin, D. A., & Resnick, M. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2000 · Cited by 201
Analysis of the Essential Functions of the C-terminal Protein/Protein Interaction Domain of Saccharomyces cerevisiae pol ε and Its Unexpected Ability to Support Growth in the Absence of the DNA Polymerase Domain
Dua, R., Levy, D. L., & Campbell, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22283 · Cited by 200
exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair
Amin, N. S., Nguyen, M.-N., Oh, S., & Kolodner, R. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5142-5155.2001 · Cited by 198
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
Lin, D. P., Wang, Y., Scherer, S. J., Clark, A. B., Yang, K., Avdievich, E., Jin, B., Werling, U., Parris, T., Kurihara, N., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2957 · Cited by 195
Requirement of the Yeast MSH3 and MSH6 Genes for MSH2-dependent Genomic Stability
Johnson, R. E., Kovvali, G. K., Prakash, L., & Prakash, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7285 · Cited by 188
Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast
Masumoto, H., Sugino, A., & Araki, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2809-2817.2000 · Cited by 184
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
Duckett, D. R., Bronstein, S. M., Taya, Y., & Modrich, P. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12384 · Cited by 178
Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ
Pavlov, Y. I., Frahm, C., McElhinny, S. A. N., Niimi, A., Suzuki, M., & Kunkel, T. A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.002 · Cited by 177
Apoptosis induced by overexpression of hMSH2 or hMLH1.
Zhang, H., Richards, B. T., Wilson, T., Lloyd, M., Cranston, A. N., Thorburn, A. M., Fishel, R. A., & Meuth, M. (1999) · PubMed · Cited by 176
Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice
Goldsby, R. E., Lawrence, N. A., Hays, L. E., Olmsted, E. A., Chen, X., Singh, M., & Preston, B. D. (2001) · Nature Medicine · doi:10.1038/88963 · Cited by 171
Self-citation
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
Yang, G., Scherer, S. J., Shell, S. S., Yang, K., Kim, M., Lipkin, M., Kucherlapati, R., Kolodner, R. D., & Edelmann, W. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.024 · Cited by 168
The Saccharomyces cerevisiae Msh2 and Msh6 Proteins Form a Complex That Specifically Binds to Duplex Oligonucleotides Containing Mismatched DNA Base Pairs
Alani, E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5604 · Cited by 167
High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading
Goldsby, R. E., Hays, L. E., Chen, X., Olmsted, E. A., Slayton, W. B., Spangrude, G. J., & Preston, B. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232340999 · Cited by 166
Self-citation
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
Reitmair, A. H., Redston, M. S., Cai, J. C., Chuang, T. C.-Y., Bjerknes, M., Cheng, H., Hay, K., Gallinger, S., Bapat, B. V., & Mak, T. W. (1996) · PubMed · Cited by 166
DNA polymerase proofreading: Multiple roles maintain genome stability
Reha-Krantz, L. J. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.06.012 · Cited by 162
Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk
Smith, T. R., Levine, E. A., Freimanis, R. I., Akman, S. A., Allen, G. O., Hoang, K. N., Liu‐Mares, W., & Hu, J. J. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn193 · Cited by 162
Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7
Friedberg, E. C., & Meira, L. B. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.09.009 · Cited by 160
The 3′→5′ exonuclease of DNA polymerase δ can substitute for the 5′ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability
Jin, Y. H., Obert, R., Burgers, P., Kunkel, T. A., Resnick, M. A., & Gordenin, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091095198 · Cited by 158
The kinetic and chemical mechanism of high-fidelity DNA polymerases
Johnson, K. A. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.01.006 · Cited by 156
DNA polymerase III, a second essential DNA polymerase, is encoded by the S. cerevisiae CDC2 gene
Sitney, K. C., Budd, M. E., & Campbell, J. L. (1989) · Cell · doi:10.1016/0092-8674(89)90582-5 · Cited by 154
The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis.
Fishel, R. A. (2001) · PubMed · Cited by 153
Functional Overlap in Mismatch Repair by Human MSH3 and MSH6
Umar, A., Risinger, J. I., Glaab, W. E., Tindall, K. R., Barrett, J. C., & Kunkel, T. A. (1998) · Genetics · doi:10.1093/genetics/148.4.1637 · Cited by 151
Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast
Pavlov, Y. I., Mian, I. M., & Kunkel, T. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00284-7 · Cited by 149
MUTYH-Null Mice Are Susceptible to Spontaneous and Oxidative Stress–Induced Intestinal Tumorigenesis
Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4802 · Cited by 143
Caretaker tumour suppressor genes that defend genome integrity
Levitt, N. C., & Hickson, I. D. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02298-0 · Cited by 138
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
Kadyrov, F. A., Genschel, J., Fang, Y., Penland, E., Edelmann, W., & Modrich, P. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903654106 · Cited by 138
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis
Hollander, M. C., Philburn, R. T., Patterson, A. D., Velasco-Miguel, S., Friedberg, E. C., Linnoila, R. I., & Fornace, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503133102 · Cited by 135
Common Genetic Variants and Risk for HPV Persistence and Progression to Cervical Cancer
WANG, S. S., González, P., Yu, K. F., Porras, C., Li, Q., Safaeian, M., Rodríguez, A. C., Sherman, M. E., Bratti, C., SCHIFFMAN, M. H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008667 · Cited by 134
Cancers beget mutations versus mutations beget cancers.
Prehn, R. T. (1994) · PubMed · Cited by 133
3′ → 5′ Exonucleases of DNA Polymerases ϵ and δ Correct Base Analog Induced DNA Replication Errors on Opposite DNA Strands in Saccharomyces cerevisiae
Shcherbakova, P. V., & Pavlov, Y. I. (1996) · Genetics · doi:10.1093/genetics/142.3.717 · Cited by 130
Noncompetitive Counteractions of DNA Polymerase ε and ISW2/yCHRAC for Epigenetic Inheritance of Telomere Position Effect in Saccharomyces cerevisiae
Iida, T., & Araki, H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.217-227.2004 · Cited by 130
Problems of somatic mutation and cancer
Frank, S. A., & Nowak, M. A. (2004) · BioEssays · doi:10.1002/bies.20000 · Cited by 129
Biochemical Characterization of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 Complex and Mispaired Bases in DNA
Marsischky, G., & Kolodner, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.26668 · Cited by 126
Schizosaccharomyces pombe Cells Lacking the Amino-Terminal Catalytic Domains of DNA Polymerase Epsilon Are Viable but Require the DNA Damage Checkpoint Control
Feng, W., & D’Urso, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4495-4504.2001 · Cited by 125
Mouse models for human DNA mismatch-repair gene defects
Wei, K., Kucherlapati, R., & Edelmann, W. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02359-6 · Cited by 124
Polymerase δ variants in RER colorectal tumours
da Costa, L. T., Liu, B., El‐Deiry, W. S., Hamilton, S. R., Kinzler, K. W., Vogelstein, B., Markowitz, S. D., Willson, J. K. V., de la Chapelle, A., Downey, K. M., et al. (1995) · Nature Genetics · doi:10.1038/ng0195-10 · Cited by 124
Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes
Pavlov, Y. I., Shcherbakova, P. V., & Rogozin, I. B. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55002-8 · Cited by 123
Cancer genetics: from Boveri and Mendel to microarrays
Balmain, A. (2001) · Nature reviews. Cancer · doi:10.1038/35094086 · Cited by 122
In Vivo Consequences of Putative Active Site Mutations in Yeast DNA Polymerases α, ε, δ, and ζ
Pavlov, Y. I., Shcherbakova, P. V., & Kunkel, T. A. (2001) · Genetics · doi:10.1093/genetics/159.1.47 · Cited by 122
Yeast Origins Establish a Strand Bias for Replicational Mutagenesis
Pavlov, Y. I., Newlon, C. S., & Kunkel, T. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00567-1 · Cited by 121
Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells
Papouli, E., Ćejka, P., & Jiricny, J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0513 · Cited by 116
DNA polymerase epsilon may be dispensable for SV40‐ but not cellular‐DNA replication.
Zlotkin, T., Kaufmann, G., Jiang, Y. Q., Lee, M. Y., Uitto, L., Syväoja, J. E., Dornreiter, I., Fanning, E., & Nethanel, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00583.x · Cited by 115
UV-B Radiation Induces Epithelial Tumors in Mice Lacking DNA Polymerase η and Mesenchymal Tumors in Mice Deficient for DNA Polymerase ι
Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01076-06 · Cited by 111
Transfer of the MSH2·MSH6 Complex from Proliferating Cell Nuclear Antigen to Mispaired Bases in DNA
Lau, P. J., & Kolodner, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200627200 · Cited by 110
Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
Tahirov, T. H., Makarova, K. S., Rogozin, I. B., Pavlov, Y. I., & Koonin, E. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-11 · Cited by 110
Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis
Chao, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj489 · Cited by 105
Mutation at the Polymerase Active Site of Mouse DNA Polymerase δ Increases Genomic Instability and Accelerates Tumorigenesis
Venkatesan, R. N., Treuting, P. M., Fuller, E. D., Goldsby, R. E., Norwood, T. H., Gooley, T. A., Ladiges, W., Preston, B. D., & Loeb, L. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00002-07 · Cited by 102
Self-citation
The Protein Components and Mechanism of Eukaryotic Okazaki Fragment Maturation
Kao, H.-I., & Bambara, R. A. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230390259382 · Cited by 100
Mutator phenotypes of yeast strains heterozygous for mutations in the MSH 2 gene
Drotschmann, K., Clark, A., Tran, H. T., Resnick, M. A., Gordenin, D. A., & Kunkel, T. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2970 · Cited by 99
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
York, S. J., & Modrich, P. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603667200 · Cited by 98
Significance of error‐avoiding mechanisms for oxidative DNA damage in carcinogenesis
Tsuzuki, T., Nakatsu, Y., & Nakabeppu, Y. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00409.x · Cited by 97
Different DNA repair strategies to combat the threat from 8-oxoguanine
Russo, M. T., Luca, G. D., Degan, P., & Bignami, M. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.03.007 · Cited by 95
Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice
Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95
Saccharomyces cerevisiae Msh2-Msh3 Acts in Repair of Base-Base Mispairs
Harrington, J. M., & Kolodner, R. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00855-07 · Cited by 93
DNA polymerases and human diseases
Sweasy, J. B., Lauper, J. M., & Eckert, K. A. (2006) · Radiation Research · doi:10.1667/rr0706.1 · Cited by 93
The DNA Polymerase Domain of polε Is Required for Rapid, Efficient, and Highly Accurate Chromosomal DNA Replication, Telomere Length Maintenance, and Normal Cell Senescence inSaccharomyces cerevisiae
Ohya, T., Kawasaki, Y., Hiraga, S., Kanbara, S., Nakajo, K., Nakashima, N., Suzuki, A., & Sugino, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111573200 · Cited by 92
Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes
Sigurdson, A. J., Hauptmann, M., Chatterjee, N., Alexander, B. H., Doody, M. M., Rutter, J. L., & Struewing, J. P. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-9 · Cited by 92
Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors
Kyo, S., Kanaya, T., Takakura, M., Tanaka, M., Yamashita, A., Inoue, H., & Inoue, M. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990315)80:6 · Cited by 90
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
Hegan, D. C., Narayanan, L., Jirik, F. R., Edelmann, W., Liskay, R. M., & Glazer, P. M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl079 · Cited by 90
Saccharomyces cerevisiae DNA Polymerase ε and Polymerase σ Interact Physically and Functionally, Suggesting a Role for Polymerase ε in Sister Chromatid Cohesion
Edwards, S., Li, C. M., Levy, D. L., Brown, J. A., Snow, P. M., & Campbell, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2733-2748.2003 · Cited by 88
Increased Rates of Genomic Deletions Generated by Mutations in the Yeast Gene Encoding DNA Polymerase δ or by Decreases in the Cellular Levels of DNA Polymerase δ
Kokoska, R. J., Stefanovic, L., DeMai, J., & Petes, T. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7490-7504.2000 · Cited by 87
Human DNA Polymerase ε Colocalizes with Proliferating Cell Nuclear Antigen and DNA Replication Late, but Not Early, in S Phase
Fuss, J. O., & Linn, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110615200 · Cited by 87
Mismatch repair proteins as sensors of alkylation DNA damage
Wang, J. Y. J., & Edelmann, W. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.013 · Cited by 86
Distinct roles of DNA polymerases delta and epsilon at the replication fork inXenopusegg extracts
Fukui, T., Yamauchi, K., Muroya, T., Akiyama, M., Maki, H., Sugino, A., & Waga, S. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00716.x · Cited by 82
Mismatch repair and response to DNA-damaging antitumour therapies
Bignami, M., Casorelli, I., & Karran, P. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00569-0 · Cited by 81
The Multiple Biological Roles of the 3′→5′ Exonuclease ofSaccharomyces cerevisiaeDNA Polymerase δ Require Switching between the Polymerase and Exonuclease Domains
Jin, Y. H., Garg, P., Stith, C. M. W., Al-Refai, H., Sterling, J. F., Murray, L. J. W., Kunkel, T. A., Resnick, M. A., Burgers, P., & Gordenin, D. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.461-471.2005 · Cited by 80
Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer
Cheo, D. L., Meira, L. B., Hammer, R. E., Burns, D. K., Doughty, A. T. B., & Friedberg, E. C. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70794-x · Cited by 79
Evidence from mutational specificity studies that yeast DNA polymerases δ and ϵ replicate different DNA strands at an intracellular replication fork 1 1Edited by A. R. Fersht
Karthikeyan, R., Vonarx, E. J., Straffon, A. F. L., Simon, M., Faye, G., & Kunz, B. A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3744 · Cited by 76
Mutator Phenotypes Caused by Substitution at a Conserved Motif A Residue in Eukaryotic DNA Polymerase δ
Venkatesan, R. N., Hsu, J. J., Lawrence, N. A., Preston, B. D., & Loeb, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510245200 · Cited by 75
Self-citation
Genetic variation in the DNA repair genes is predictive of outcome in lung cancer
Matakidou, A., Galta, R. E., Webb, E. L., Rudd, M. F., Bridle, H. L., Eisen, T. G., & Houlston, R. S. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm190 · Cited by 74
Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors.
Cheo, D. L., Meira, L. B., Burns, D. K., Reis, A., Issac, T., & Friedberg, E. C. (2000) · PubMed · Cited by 73
A cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability
Daee, D. L., Mertz, T. M., & Shcherbakova, P. V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907526106 · Cited by 72
Cancer Genome Sequencing—An Interim Analysis
Fox, E., Salk, J. J., & Loeb, L. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1231 · Cited by 70
Genetic Instability Is Not a Requirement for Tumor Development
Bodmer, W. F. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6544 · Cited by 69
The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.
Buermeyer, A. B., Patten, C. W.-V., Baker, S. M., & Liskay, R. M. (1999) · PubMed · Cited by 68
Cancer: the evolved consequence of a destabilized genome
Anderson, G. R., Stoler, D. L., & Brenner, B. M. (2001) · BioEssays · doi:10.1002/bies.1149 · Cited by 66
EXO1 and MSH6 Are High-Copy Suppressors of Conditional Mutations in the MSH2 Mismatch Repair Gene of Saccharomyces cerevisiae
Sokolsky, T. D., & Alani, E. (2000) · Genetics · doi:10.1093/genetics/155.2.589 · Cited by 65
Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice
Andrew, S. E., Reitmair, A. H., Fox, J. A., Hsiao, L., Francis, A., McKinnon, M. L., Mak, T. W., & Jirik, F. R. (1997) · Oncogene · doi:10.1038/sj.onc.1201180 · Cited by 65
Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.
Reitmair, A. H., Risley, R., Bristow, R. G., Wilson, T., Ganesh, A. N., Jang, A., Peacock, J., Benchimol, S., Hill, R. P., Mak, T. W., et al. (1997) · PubMed · Cited by 64

Flagged first, then by citations

10 of the 251 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Zhou, 2003, Highly conserved region of the catalytic subunit of DNA polymerase epsilon in human breast cancer, Exp Oncol, 25, 206
Boveri, 1902, Über mehrpolige Mitosen als Mittel zur Analyze des Zellkerns, Verh Dtsch Zool Ges Würzburg, 35, 67

Sorted by citations

Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Wang, Y., Waters, J., Leung, M. L., Unruh, A., Roh, W., Shi, X., Chen, K., Scheet, P., Vattathil, S., Liang, H., et al. (2014) · Nature · doi:10.1038/nature13600 · Cited by 1,029
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Palles, C., Cazier, J., Howarth, K. M., Domingo, E., Jones, A. M., Broderick, P., Kemp, Z., Spain, S. L., Guarino, E., Salguero, I., et al. (2012) · Nature Genetics · doi:10.1038/ng.2503 · Cited by 1,008
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Smith, M. T., Guyton, K., Gibbons, C., Fritz, J. M., Portier, C., Rusyn, I., DeMarini, D., Caldwell, J., Kavlock, R., Lambert, P., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509912 · Cited by 599
Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System
Griendling, K. K., Touyz, R. M., Zweier, J. L., Dikalov, S., Chilian, W. M., Chen, Y., Harrison, D. G., & Bhatnagar, A. (2016) · Circulation Research · doi:10.1161/res.0000000000000110 · Cited by 470
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes
Kim, T., Laird, P. W., & Park, P. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.015 · Cited by 387

See all 163

Authors: Preston, B. D., Albertson, T. M., & Herr, A. J.
Affiliations: University of Washington (US)
Corresponding author: Preston, Bradley D.
ORCID: Herr, Alan J.
Venue: Seminars in Cancer Biology
Publisher: Elsevier BV
Published: 2010-10
Volume: 20
Issue: 5
Pages: 281-293
ISSN: 1044-579X (ISSN-L)
DOI: 10.1016/j.semcancer.2010.10.009
PMC: PMC2993855
OpenAlex: W2056156376
Cited by: 160
References: 251
Citations by year: 2026: 6 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 17 · 2012: 16
FWCI: 1.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cancer Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P01AG001751)
National Cancer Institute (P20CA103728, R01CA111582, P01CA077852, R01CA098243)
National Institute of Environmental Health Sciences (R01ES009927, P30ES007033)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: DNA replication fidelity, carcinogenesis, replication errors, mutation avoidance, positive selection, genome stability
MeSH terms: Animals, Chromosome Aberrations, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Mutation, Neoplasms, Gene Rearrangement, Point Mutation, Microsatellite Instability, DNA Mismatch Repair

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DNA replication fidelity and cancer

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