Cited by 163DNA Repair MechanismsCancer-related Molecular PathwaysGenetic factors in colorectal cancer

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DNA replication fidelity and cancer

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Preston, Bradley D., Albertson, Tina M., Herr, Alan J.·2010·Seminars in Cancer Biology

DOI 10.1016/j.semcancer.2010.10.009PMC PMC2993855

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Abstract

Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

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Authors: Preston, B. D., Albertson, T. M., & Herr, A. J.
Affiliations: University of Washington (US)
Corresponding author: Preston, Bradley D.
ORCID: Herr, Alan J.
Venue: Seminars in Cancer Biology
Publisher: Elsevier BV
Published: 2010-10
Volume: 20
Issue: 5
Pages: 281-293
ISSN: 1044-579X (ISSN-L)
DOI: 10.1016/j.semcancer.2010.10.009
PMC: PMC2993855
OpenAlex: W2056156376
Cited by: 160
References: 251
Citations by year: 2026: 6 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 17 · 2012: 16
FWCI: 1.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cancer Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P01AG001751)
National Cancer Institute (P20CA103728, R01CA111582, P01CA077852, R01CA098243)
National Institute of Environmental Health Sciences (R01ES009927, P30ES007033)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: DNA replication fidelity, carcinogenesis, replication errors, mutation avoidance, positive selection, genome stability
MeSH terms: Animals, Chromosome Aberrations, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Mutation, Neoplasms, Gene Rearrangement, Point Mutation, Microsatellite Instability, DNA Mismatch Repair

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DNA replication fidelity and cancer

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