The DOI matches its Crossref record; 241 of the 251 references it cites were found in a registry or an index.
DNA replication fidelity and cancer
Open accessAbstract
Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.
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“Additionally, tumor genomes can become highly unstable as a result of impaired DNA damage repair or DNA proofreading functions, giving rise to spontaneous mutations throughout a cancer’s lifespan [98].”
From KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance (2024) · cites this paper as [98]
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Cites
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Clonal evolution in breast cancer revealed by single nucleus genome sequencing
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The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes
Kim, T., Laird, P. W., & Park, P. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.015 · Cited by 387
Metadata
- Authors
- Preston, B. D., Albertson, T. M., & Herr, A. J.
- Affiliations
- University of Washington (US)
- Corresponding author
- Preston, Bradley D.
- ORCID
- Herr, Alan J.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 20
- Issue
- 5
- Pages
- 281-293
- ISSN
- 1044-579X (ISSN-L)
- PMC
- PMC2993855
- OpenAlex
- W2056156376
- Cited by
- 160
- References
- 251
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 17 · 2012: 16
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cancer Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG001751)
- National Cancer Institute (P20CA103728, R01CA111582, P01CA077852, R01CA098243)
- National Institute of Environmental Health Sciences (R01ES009927, P30ES007033)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- DNA replication fidelity, carcinogenesis, replication errors, mutation avoidance, positive selection, genome stability
- MeSH terms
- Animals, Chromosome Aberrations, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Mutation, Neoplasms, Gene Rearrangement, Point Mutation, Microsatellite Instability, DNA Mismatch Repair
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