The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
CRISPR/Cas9 for cancer research and therapy
Open accessAbstract
CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First discovered in bacteria as part of an adaptive immune system, CRISPR/Cas9 and modified versions have found a widespread use to engineer genomes and to activate or to repress the expression of genes. As such, CRISPR/Cas9 promises to accelerate cancer research by providing an efficient technology to dissect mechanisms of tumorigenesis, identify targets for drug development, and possibly arm cells for cell-based therapies. Here, we review current applications of the CRISPR/Cas9 technology for cancer research and therapy. We describe novel Cas9 variants and how they are used in functional genomics to discover novel cancer-specific vulnerabilities. Furthermore, we highlight the impact of CRISPR/Cas9 in generating organoid and mouse models of cancer. Finally, we provide an overview of the first clinical trials that apply CRISPR/Cas9 as a therapeutic approach against cancer.
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Cited by
The Limitless Future of RNA Therapeutics
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Metadata
- Authors
- Zhan, T., Rindtorff, N., Betge, J., Ebert, M. P., & Boutros, M.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 55
- Pages
- 106-119
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W2803039783
- Cited by
- 328
- References
- 135
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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