The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functions and regulation of the APOBEC family of proteins
Open accessAbstract
APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in the APOBEC family to be functionally characterized. Under appropriate conditions APOBEC1 also deaminates deoxycytidine in single-stranded DNA (ssDNA). The other ten members of the APOBEC family have not been fully characterized however several have deoxycytidine deaminase activity on ssDNAs. Despite the nucleic acid substrate preferences of different APOBEC proteins, a common feature appears to be their intrinsic ability to bind to RNA as well as to ssDNA. RNA binding to APOBEC proteins together with protein-protein interactions, post-translation modifications and subcellular localization serve as biological modulators controlling the DNA mutagenic activity of these potentially genotoxic proteins.
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Citations
Cites
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Mangeat, B., Turelli, P., Caron, G., Friedli, M., Perrin, L., & Trono, D. (2003) · Nature · doi:10.1038/nature01709 · Cited by 1,486
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Bolli, N., Avet-Loiseau, H., Wedge, D. C., Van Loo, P., Alexandrov, L. B., Martincorena, I., Dawson, K. J., Iorio, F., Nik-Zainal, S., Bignell, G. R., et al. (2014) · Nature Communications · doi:10.1038/ncomms3997 · Cited by 875
The APOBEC Protein Family: United by Structure, Divergent in Function
Salter, J. D., Bennett, R. P., & Smith, H. C. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.001 · Cited by 408
Self-citationThe double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme
Sharma, S., Patnaik, S. K., Taggart, R. T., & Baysal, B. E. (2016) · Scientific Reports · doi:10.1038/srep39100 · Cited by 97
Host Immune Response Driving SARS-CoV-2 Evolution
Wang, R., Hozumi, Y., Zheng, Y.-H., Yin, C., & Wei, G.-W. (2020) · Viruses · doi:10.3390/v12101095 · Cited by 74
Metadata
- Authors
- Smith, H. C., Bennett, R. P., Kizilyer, A., McDougall, W. M., & Prohaska, K. M.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 23
- Issue
- 3
- Pages
- 258-268
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2091939828
- Cited by
- 202
- References
- 1
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, H. C., Bennett, R. P., Kizilyer, A., McDougall, W. M., & Prohaska, K. M. (2012). Functions and regulation of the APOBEC family of proteins. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2011.10.004
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