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mTORC1 signaling controls multiple steps in ribosome biogenesis
Abstract
Ribosome biogenesis is critical for cells to generate the ribosomes they need for protein synthesis in order to survive, grow and proliferate. It is a complex process, involving the coordinated production of four different RNA species and about 80 proteins, as well as their assembly into functional ribosomal subunits. Given its high demand for amino acids and nucleotides, it is also a metabolically expensive process for the cell. The mammalian target of rapamycin complex 1 (mTORC1) is a protein kinases which is activated by nutrients, anabolic hormones and oncogenic signaling pathways. mTORC1 positively regulates several steps in ribosome biogenesis, including ribosomal RNA transcription, the synthesis of ribosomal proteins and other components required for ribosome assembly. mTORC1 can thus coordinate stimuli which promote ribosome production with the various steps involved in this process. Although important advances have been made in our understanding of mTORC1 signaling, major questions remain about the molecular mechanisms by which it regulates ribosome biogenesis.
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“However, mTORC1 increases not only protein synthesis from existing ribosomes but also the synthesis of more ribosomes, a process known as ribosomal biogenesis [176].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [176]
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Metadata
- Authors
- Iadevaia, V., Liu, R., & Proud, C. G.
- Affiliations
- University of Southampton (GB)
- Corresponding author
- Proud, Christopher G.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 36
- Pages
- 113-120
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W1965611273
- Cited by
- 248
- References
- 95
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 19 · 2023: 28 · 2022: 29 · 2021: 29 · 2020: 20 · 2019: 21 · 2018: 26 · 2017: 18 · 2016: 11 · 2015: 9 · 2014: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- mTORC1 signaling, ribosome biogenesis, rDNA transcription, ribosomal protein synthesis, ribosome assembly, nutrient signaling, kinase regulation
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Humans, Ribosomal Proteins, Ribosomes, RNA Polymerase I, RNA Polymerase III, RNA, Ribosomal, Protein Biosynthesis, Signal Transduction, Multiprotein Complexes, TOR Serine-Threonine Kinases
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