Cited by 248PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanismsBiochemical and Molecular Research

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mTORC1 signaling controls multiple steps in ribosome biogenesis

Iadevaia, Valentina, Liu, Rui, Proud, Christopher G.·2014·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2014.08.004

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Abstract

Ribosome biogenesis is critical for cells to generate the ribosomes they need for protein synthesis in order to survive, grow and proliferate. It is a complex process, involving the coordinated production of four different RNA species and about 80 proteins, as well as their assembly into functional ribosomal subunits. Given its high demand for amino acids and nucleotides, it is also a metabolically expensive process for the cell. The mammalian target of rapamycin complex 1 (mTORC1) is a protein kinases which is activated by nutrients, anabolic hormones and oncogenic signaling pathways. mTORC1 positively regulates several steps in ribosome biogenesis, including ribosomal RNA transcription, the synthesis of ribosomal proteins and other components required for ribosome assembly. mTORC1 can thus coordinate stimuli which promote ribosome production with the various steps involved in this process. Although important advances have been made in our understanding of mTORC1 signaling, major questions remain about the molecular mechanisms by which it regulates ribosome biogenesis.

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2 of the 95 references couldn’t be matched to a known paper.

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Pianese, 1896, Beitraege zur Histologie und Aetiologie der Carconoms, Beitr Pathol Anat Allgem Pathol, 142, 1

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“Enhancing ribosome biogenesis is a major function of mTORC1 [33].”
Background
mTOR in Brain Physiology and Pathologies
Bockaert, J., & Marin, P. (2015) · Physiological Reviews · doi:10.1152/physrev.00038.2014 · Cited by 379
“In addition, mTORC1, via S6K1, promotes the expression of ribosomal RNA (rRNA), the transcription of 5S rRNA, and transfer RNA (tRNA) and thereby contributes to ribosome biogenesis (109).”
Background

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Authors: Iadevaia, V., Liu, R., & Proud, C. G.
Affiliations: University of Southampton (GB)
Corresponding author: Proud, Christopher G.
ORCID: Iadevaia, Valentina
Liu, Rui
Proud, Christopher G.
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2014-12
Volume: 36
Pages: 113-120
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2014.08.004
OpenAlex: W1965611273
Cited by: 248
References: 95
Citations by year: 2026: 10 · 2025: 25 · 2024: 19 · 2023: 28 · 2022: 29 · 2021: 29 · 2020: 20 · 2019: 21 · 2018: 26 · 2017: 18 · 2016: 11 · 2015: 9 · 2014: 3
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Open Research (University of Surrey) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders: Cancer Research UK
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: mTORC1 signaling, ribosome biogenesis, rDNA transcription, ribosomal protein synthesis, ribosome assembly, nutrient signaling, kinase regulation
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Humans, Ribosomal Proteins, Ribosomes, RNA Polymerase I, RNA Polymerase III, RNA, Ribosomal, Protein Biosynthesis, Signal Transduction, Multiprotein Complexes, TOR Serine-Threonine Kinases

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mTORC1 signaling controls multiple steps in ribosome biogenesis

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