The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
MYC and metabolism on the path to cancer
Open accessAbstract
The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic programs that orchestrate biological processes to promote growth and proliferation. Altered metabolism characterized by heightened nutrients uptake, enhanced glycolysis and glutaminolysis and elevated fatty acid and nucleotide synthesis is the hallmark of MYC-driven cancer. Recent evidence strongly suggests that Myc-dependent metabolic reprogramming is critical for tumorigenesis, which could be attenuated by targeting specific metabolic pathways using small drug-like molecules. Understanding the complexity of MYC-mediated metabolic re-wiring in cancers as well as how MYC cooperates with other metabolic drivers such as mammalian target of rapamycin (mTOR) will provide translational opportunities for cancer therapy.
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1 retracted
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Cited by
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Hay, N. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.77 · Cited by 1,115
LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Wang, Y., Lu, J.-H., Wu, Q.-N., Jin, Y., Wang, D.-S., Chen, Y.-X., Liu, J., Luo, X.-J., Meng, Q., Pu, H.-Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1105-0 · Cited by 507
Rewiring urea cycle metabolism in cancer to support anabolism
Keshet, R., Szlosarek, P., Carracedo, A., & Erez, A. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0054-z · Cited by 323
Drosophila melanogaster: A Model Organism to Study Cancer
Mirzoyan, Z., Sollazzo, M., Allocca, M., Valenza, A. M., Grifoni, D., & Bellosta, P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00051 · Cited by 317
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
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Metadata
- Authors
- Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 43
- Pages
- 11-21
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W1159008209
- Cited by
- 332
- References
- 101
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V. (2015). MYC and metabolism on the path to cancer. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2015.08.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
