The DOI matches its Crossref record; 138 of the 139 references it cites were found in a registry or an index.
Extracellular matrix scaffolding in angiogenesis and capillary homeostasis
Open accessAbstract
The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to blood vessels and regulates properties of endothelial cells and pericytes. The major components of the BM are collagen IV, laminins, heparan sulfate proteoglycans and nidogen and also associated proteins such as collagen XVIII and fibronectin. Their organization and scaffolding in the BM is required for proper capillary morphogenesis and maintenance of vascular homeostasis. The BM also regulates vascular mechanosensing. A better understanding of the mechanical and structural properties of the vascular BM and interstitial ECM therefore opens new perspectives to control physiological and pathological angiogenesis and vascular homeostasis. The overall aim of this review is to explain how ECM scaffolding influences angiogenesis and capillary integrity.
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“For instance, laminin, collagen IV, and fibronectin loss may impair angiogenesis [60, 61], and glycosaminoglycans (GAGs) removal accompanies growth factors depletion, impairing subsequent cell migration and differentiation [53].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [60]
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Cites
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Mathew‐Steiner, S. S., Roy, S., & Sen, C. K. (2021) · Bioengineering · doi:10.3390/bioengineering8050063 · Cited by 1,080
3D and 4D Printing of Polymers for Tissue Engineering Applications
Tamay, D. G., Usal, T. D., Alagoz, A. S., Yücel, D., Hasırcı, N., & Hasırcı, V. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00164 · Cited by 432
Kasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316
Hydrogel Network Dynamics Regulate Vascular Morphogenesis
Zhao, W., Schnellmann, R., Pruitt, H. C., & Gerecht, S. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.08.005 · Cited by 166
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Metadata
- Authors
- Marchand, M., Monnot, C., Muller, L., & Germain, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Germain, Stéphane
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 89
- Pages
- 147-156
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2891724652
- Cited by
- 205
- References
- 139
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 29 · 2023: 28 · 2022: 41 · 2021: 32 · 2020: 23 · 2019: 18
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Seminars in Cell and Developmental Biology (acceptedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Fondation pour la Recherche Médicale
- INSERM
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- extracellular matrix, angiogenesis, vascular basement membrane, type IV collagen, laminin, heparan sulfate proteoglycans, nidogen, collagen XVIII, fibronectin, pericytes, endothelial cells, capillary morphogenesis, vascular integrity
- MeSH terms
- Basement Membrane, Blood Vessels, Extracellular Matrix, Fibronectins, Humans, Laminin, Membrane Glycoproteins, Neovascularization, Pathologic, Neovascularization, Physiologic, Heparan Sulfate Proteoglycans, Pericytes, Endothelial Cells, Collagen Type XVIII
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