Cited by 205Cellular Mechanics and InteractionsAngiogenesis and VEGF in CancerCell Adhesion Molecules Research

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Extracellular matrix scaffolding in angiogenesis and capillary homeostasis

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Marchand, Marion, Monnot, Catherine, Muller, Laurent, Germain, Stéphane·2019·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2018.08.007

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Abstract

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to blood vessels and regulates properties of endothelial cells and pericytes. The major components of the BM are collagen IV, laminins, heparan sulfate proteoglycans and nidogen and also associated proteins such as collagen XVIII and fibronectin. Their organization and scaffolding in the BM is required for proper capillary morphogenesis and maintenance of vascular homeostasis. The BM also regulates vascular mechanosensing. A better understanding of the mechanical and structural properties of the vascular BM and interstitial ECM therefore opens new perspectives to control physiological and pathological angiogenesis and vascular homeostasis. The overall aim of this review is to explain how ECM scaffolding influences angiogenesis and capillary integrity.

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Authors: Marchand, M., Monnot, C., Muller, L., & Germain, S.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Germain, Stéphane
ORCID: Marchand, Marion
Monnot, Catherine
Muller, Laurent
Germain, Stéphane
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2019-05
Volume: 89
Pages: 147-156
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2018.08.007
OpenAlex: W2891724652
Cited by: 205
References: 139
Citations by year: 2026: 14 · 2025: 20 · 2024: 29 · 2023: 28 · 2022: 41 · 2021: 32 · 2020: 23 · 2019: 18
FWCI: 2.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 337 d)
Locations: Seminars in Cell and Developmental Biology (acceptedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by-nc)
Funders: Fondation pour la Recherche Médicale
INSERM
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: extracellular matrix, angiogenesis, vascular basement membrane, type IV collagen, laminin, heparan sulfate proteoglycans, nidogen, collagen XVIII, fibronectin, pericytes, endothelial cells, capillary morphogenesis, vascular integrity
MeSH terms: Basement Membrane, Blood Vessels, Extracellular Matrix, Fibronectins, Humans, Laminin, Membrane Glycoproteins, Neovascularization, Pathologic, Neovascularization, Physiologic, Heparan Sulfate Proteoglycans, Pericytes, Endothelial Cells, Collagen Type XVIII

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Extracellular matrix scaffolding in angiogenesis and capillary homeostasis

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