The force is strong with this one: metabolism (Over)powers stem cell fate
Open accessAbstract
Compared to their differentiated progeny, stem cells are often characterized by distinct metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial carbohydrate oxidation. Until recently, the metabolic program of stem cells had been thought to be a byproduct of the environment, rather than an intrinsic feature determined by the cell itself. However, new studies highlight the impact of metabolic behavior on the maintenance and function of intestinal stem cells and hair follicle stem cells. This Review summarizes and discusses the evidence that metabolism is not a mere consequence of, but rather influential on stem cell fate.
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Hair follicle stem cells are not continuously proliferative and instead remain dormant unless induced to divide during a new hair cycle.
“Unlike ISCs, hair follicle stem cells (HFSCs) are not continuously proliferative and instead remain dormant unless induced to divide during a new hair cycle (207).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [207]
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- Authors
- Wei, P., Dove, K. K., Bensard, C., Schell, J. C., & Rutter, J.
- Affiliations
- University of Utah (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rutter, Jared
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 28
- Issue
- 7
- Pages
- 551-559
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC6005741
- OpenAlex
- W2789287106
- Cited by
- 47
- References
- 40
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 3 · 2022: 11 · 2021: 10 · 2020: 2 · 2019: 8 · 2018: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (T32HL007576)
- National Cancer Institute (R01CA228346)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- stem cell metabolism, stem cell fate, intestinal stem cells, hair follicle stem cells, anaerobic glycolysis, mitochondrial metabolism, metabolic reprogramming, stem cell maintenance
- MeSH terms
- Animals, Humans, Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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