Cited by 47Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerHematopoietic Stem Cell Transplantation

The force is strong with this one: metabolism (Over)powers stem cell fate

Open access
Wei, Peng, Dove, Katja K., Bensard, Claire, Schell, John C., Rutter, Jared·2018·Trends in Cell Biology

Abstract

Compared to their differentiated progeny, stem cells are often characterized by distinct metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial carbohydrate oxidation. Until recently, the metabolic program of stem cells had been thought to be a byproduct of the environment, rather than an intrinsic feature determined by the cell itself. However, new studies highlight the impact of metabolic behavior on the maintenance and function of intestinal stem cells and hair follicle stem cells. This Review summarizes and discusses the evidence that metabolism is not a mere consequence of, but rather influential on stem cell fate.

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Crossref · 10.1016/j.tcb.2018.02.007

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  • Hair follicle stem cells are not continuously proliferative and instead remain dormant unless induced to divide during a new hair cycle.

    “Unlike ISCs, hair follicle stem cells (HFSCs) are not continuously proliferative and instead remain dormant unless induced to divide during a new hair cycle (207).”

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Authors
Wei, P., Dove, K. K., Bensard, C., Schell, J. C., & Rutter, J.
Affiliations
  • University of Utah (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Rutter, Jared
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2018-07
Volume
28
Issue
7
Pages
551-559
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2789287106
Cited by
47
References
40
Citations by year
2025: 7 · 2024: 3 · 2023: 3 · 2022: 11 · 2021: 10 · 2020: 2 · 2019: 8 · 2018: 3
FWCI
0.60
Type
journal article
Language
en
Open access
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Heart, Lung, and Blood Institute (T32HL007576)
  • National Cancer Institute (R01CA228346)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
stem cell metabolism, stem cell fate, intestinal stem cells, hair follicle stem cells, anaerobic glycolysis, mitochondrial metabolism, metabolic reprogramming, stem cell maintenance
MeSH terms
Animals, Humans, Stem Cells

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