The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Macrophages and Immunologic Inflammation of the Kidney
Open accessAbstract
Monocyte derived tissue effector cells, macrophages, are present in large numbers in all forms of kidney disease with inflammation. Their roles in inflammation and the molecular effectors of macrophage function have been difficult to decipher. With the advent of modern genetic tools and mouse models of human disease, great insight into monocyte/macrophage biology has been forthcoming. In this review we will place macrophage study in its historical context, define immunological diseases of the kidney, and broaden its definition to encompass current thinking of the immune response to kidney injury, highlight key advances of the study of monocyte/macrophages in kidney diseases, and identify new therapeutic pathways and targets that hinge around macrophage function. Here we advance the case that targeting macrophage activation and phenotype is leading to new therapies in treatment of many acute and chronic kidney diseases.
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Cites
Exploring the full spectrum of macrophage activation
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Resolution of inflammation: the beginning programs the end
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Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
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Self-citationMacrophage Polarization Comes of Age
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CCR1 and CCR5 promote hepatic fibrosis in mice
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Cited by
Cellular and molecular mechanisms of renal fibrosis
Liu, Y. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.149 · Cited by 1,446
Immune and Inflammatory Role in Renal Disease
Imig, J. D., & Ryan, M. J. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120028 · Cited by 356
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170
CD4+ T Lymphocytes, Especially Th2 Cells, Contribute to the Progress of Renal Fibrosis
Liu, L., Kou, P., Zeng, Q., Pei, G., Li, Y., Liang, H., Xu, G., & Chen, S. (2012) · American Journal of Nephrology · doi:10.1159/000343283 · Cited by 111
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
Nakagawa, N., Barron, L., Gomez, I. G., Johnson, B. G., Roach, A. M., Kameoka, S., Jack, R. M., Lupher, M. L., Gharib, S. A., & Duffield, J. S. (2016) · JCI Insight · doi:10.1172/jci.insight.87446 · Cited by 59
Self-citation
Metadata
- Authors
- Duffield, J. S.
- Venue
- Seminars in Nephrology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 30
- Issue
- 3
- Pages
- 234-254
- ISSN
- 0270-9295 (ISSN-L)
- OpenAlex
- W1994455716
- Cited by
- 235
- References
- 11
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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