Cited by 1Infant Nutrition and HealthBreastfeeding Practices and InfluencesAnimal Diversity and Health Studies

Maternal diet and nutritional status during pregnancy and lactation: a review of implications on milk composition and lactation outcomes

Ayande, Ruthfirst, Sen, Sarbattama, Robinson, Daniel T.·2026·Seminars in Perinatology

Abstract

Maternal diet and nutritional status during lactation have important implications for human milk composition and lactation outcomes, yet the strength and consistency of these associations remain incompletely understood. This narrative review synthesizes current evidence on (1) the role of maternal dietary intake on human milk macronutrients, fatty acids, human milk oligosaccharides (HMOs), and other bioactive compounds; (2) the influence of maternal nutritional status, including body mass index (BMI), gestational weight gain, gestational diabetes, food insecurity, and biochemical nutrient markers, on milk composition; and (3) the relationship between maternal diet and nutritional status and lactation outcomes, including initiation, duration, and milk production. Methodological heterogeneity in dietary assessment, milk sampling protocols, and definitions of nutritional status limits comparability across studies. Standardized approaches and mechanistic research are needed to clarify causal pathways and identify modifiable targets to optimize milk composition and support successful lactation.

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Authors
Ayande, R., Sen, S., & Robinson, D. T.
Affiliations
  • Yale University (US)
  • Brown University (US)
  • Northwestern University (US)
Corresponding author
Ayande, Ruthfirst
Venue
Seminars in Perinatology
Publisher
Elsevier BV
Published
2026-08
Volume
50
Issue
5
Pages
152273
ISSN
0146-0005 (ISSN-L)
OpenAlex
W7165388785
Cited by
1
References
98
Citations by year
2026: 1
FWCI
1.14
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Perinatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Animal Diversity and Health Studies
Keywords
maternal diet, maternal nutritional status, breast milk composition, human milk oligosaccharides, bioactive compounds, body mass index, gestational weight gain, gestational diabetes mellitus, food insecurity, milk production, lactation onset, lactation length
MeSH terms
Gestational Weight Gain, Diet, Female, Humans, Lactation, Milk, Human, Nutritional Status, Pregnancy, Body Mass Index, Maternal Nutritional Physiological Phenomena

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