Maternal diet and nutritional status during pregnancy and lactation: a review of implications on milk composition and lactation outcomes
Abstract
Maternal diet and nutritional status during lactation have important implications for human milk composition and lactation outcomes, yet the strength and consistency of these associations remain incompletely understood. This narrative review synthesizes current evidence on (1) the role of maternal dietary intake on human milk macronutrients, fatty acids, human milk oligosaccharides (HMOs), and other bioactive compounds; (2) the influence of maternal nutritional status, including body mass index (BMI), gestational weight gain, gestational diabetes, food insecurity, and biochemical nutrient markers, on milk composition; and (3) the relationship between maternal diet and nutritional status and lactation outcomes, including initiation, duration, and milk production. Methodological heterogeneity in dietary assessment, milk sampling protocols, and definitions of nutritional status limits comparability across studies. Standardized approaches and mechanistic research are needed to clarify causal pathways and identify modifiable targets to optimize milk composition and support successful lactation.
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Associations between maternal diet quality in pregnancy and infant feeding practices
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Associations Between Human Milk Oligosaccharides and Maternal Nutrition: Latvian Study
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Cited by
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Alemayohu, M. A., Loperfido, F., Cazzoletti, L., Zanolin, M. E., Masri, D. E., Bianco, I., Ferrara, C., Cerbo, R. M., Ghirardello, S., Maccarini, B., et al. (2026) · Nutrients · doi:10.3390/nu18183038
- Authors
- Ayande, R., Sen, S., & Robinson, D. T.
- Affiliations
- Yale University (US)
- Brown University (US)
- Northwestern University (US)
- Corresponding author
- Ayande, Ruthfirst
- Venue
- Seminars in Perinatology
- Publisher
- Elsevier BV
- Published
- 2026-08
- Volume
- 50
- Issue
- 5
- Pages
- 152273
- ISSN
- 0146-0005 (ISSN-L)
- OpenAlex
- W7165388785
- Cited by
- 1
- References
- 98
- Citations by year
- 2026: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Seminars in Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
- Life Sciences › Agricultural and Biological Sciences › Food Science › Animal Diversity and Health Studies
- Keywords
- maternal diet, maternal nutritional status, breast milk composition, human milk oligosaccharides, bioactive compounds, body mass index, gestational weight gain, gestational diabetes mellitus, food insecurity, milk production, lactation onset, lactation length
- MeSH terms
- Gestational Weight Gain, Diet, Female, Humans, Lactation, Milk, Human, Nutritional Status, Pregnancy, Body Mass Index, Maternal Nutritional Physiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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