The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Intrauterine infection and preterm labor
Open accessAbstract
Summary Preterm labor is defined as labor that begins before 37 completed weeks of pregnancy. More than 12% of infants born in the USA are preterm. At least 40% of preterm births are associated with intrauterine infection. Toll-like receptors (TLRs) are members of a family of cell-surface proteins responsible for recognition of a diverse spectrum of bacterial, viral and fungal pathogens. TLRs initiate the host innate (i.e. non-adaptive) immune response, inducing a proinflammatory cascade involving cytokines, chemokines, prostaglandins, and other effector molecules that result in the characteristic phenomena of labor, such as uterine contractions and rupture of fetal membranes. These cascades may also be activated by mechanisms that are not primarily infectious but are accompanied by inflammatory responses. Now that the molecular mechanisms linking infection and labor have been, to a large extent, elucidated, the challenge is to identify points of overlap with non-infectious causes of labor and to find intervention strategies that can minimize the negative impact of preterm delivery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Prevention of recurrent preterm delivery by 17 alpha–hydroxyprogesterone caproate
Meis, P. J., Klebanoff, M., Thom, E., Dombrowski, M. P., Sibai, B., Moawad, A. H., Spong, C. Y., Hauth, J. C., Miodovnik, M., Varner, M. W., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035140 · Cited by 1,555
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401
Zarember, K. A., & Godowski, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.554 · Cited by 1,250
Hassan, S. S., Romero, R., Vidyadhari, D., Fusey, S., Baxter, J. K., Khandelwal, M., Vijayaraghavan, J., Trivedi, Y., Soma‐Pillay, P., Sambarey, P., et al. (2011) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.9017 · Cited by 923
The Role of Inflammation and Infection in Preterm Birth
Romero, R., Espinoza, J., Gonçalves, L., Kusanovic, J., Friel, L., & Hassan, S. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2006-956773 · Cited by 897
DiGiulio, D. B., Romero, R., Amogan, H. P., Kusanovic, J. P., Bik, E. M., Gotsch, F., Kim, C. J., Erez, O., Edwin, S., & Relman, D. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003056 · Cited by 798
da Fonseca, E. B., Bittar, R. E., Carvalho, M. H. B., & Zugaib, M. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.41 · Cited by 789
Romero, R., Sirtori, M., Oyarzun, E., Avila, C., Mazor, M., Callahan, R., Sabo, V., Athanassiadis, A. P., & Hobbins, J. C. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90409-2 · Cited by 678
Romero, R., Gonzalez, R., Sepulveda, W., Brandt, F., Ramirez, M., Sorokin, Y., Mazor, M., Treadwell, M. C., & Cotton, D. B. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(12)80043-3 · Cited by 597
Cited by
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698
Gakidou, E., Afshin, A., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulle, A. M., Abera, S. F., Aboyans, V., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32366-8 · Cited by 2,406
Preterm labor: One syndrome, many causes
Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development
Yockey, L. J., & Iwasaki, A. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.017 · Cited by 559
Bryce, E., Gurung, S., Tong, H., Katz, J., Lee, A. C., Black, R. E., & Walker, N. (2022) · Journal of Global Health · doi:10.7189/jogh.12.04013 · Cited by 32
Metadata
- Authors
- Agrawal, V., & Hirsch, E.
- Venue
- Seminars in Fetal and Neonatal Medicine
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 17
- Issue
- 1
- Pages
- 12-19
- ISSN
- 1744-165X (ISSN-L)
- OpenAlex
- W2027759577
- Cited by
- 332
- References
- 82
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Intrauterine infection and preterm labor. https://app.cochat.ai/papers/10.1016/j.siny.2011.09.001
- The paper
- Agrawal, V., & Hirsch, E. (2012). Intrauterine infection and preterm labor. Seminars in Fetal and Neonatal Medicine. https://doi.org/10.1016/j.siny.2011.09.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
