Genetic and epigenetic factors associated with depression: an updated overview

Alshaya, Dalal S.

doi:10.1016/j.sjbs.2022.103311

Cited by 81Genetic Associations and EpidemiologyEpigenetics and DNA MethylationTreatment of Major Depression

Genetic and epigenetic factors associated with depression: an updated overview

Open access

Alshaya, Dalal S.·2022·Saudi Journal of Biological Sciences

DOI 10.1016/j.sjbs.2022.103311PMC PMC9232544

Open this paper in CoChat — free account Open PDF

Abstract

Depression is a complex psychiatric disturbance involving many environmental, genetic, and epigenetic factors. Until now, genetic, and non-genetic studies are still on the way to understanding the complex mechanism of this disease, and there are still many questions that have not yet been answered. Depression includes a large spectrum of heterogeneous symptoms correlated to the deficit of a range of psychological, cognitive, and emotional processes, and it affects various age groups. It is classified into several types according to the severity of symptoms, time of occurrence, and time. Following the World Health Organization (WHO), depression attacks near 350 million persons globally. Several factors overlap in causing depression, including genetic and epigenetic factors, environmental conditions, various stresses, lack of some nutrients to which people are exposed, and excessive stress and abuse in childhood. This study included conducting surveys on depression and new treatment trends based on epigenetic factors associated with the occurrence of the disease. Epigenetic factors provide a completely novel dimension to therapeutic approaches as most diseases are not monogenic, and it is likely that the environment has a significant contribution. Epigenetic inheritance is included in many mental and psychiatric disorders such as depression. In general, epigenetic modifications could be summarized in 3 major points: DNA methylation, histone modification, and non-mediated regulation of RNA (ncRNA). This study also describes some genes associated with one of the depressive disorders using bioinformatics tools and gene bank and had the genes: SLC6A4, COMT, TPH2, FKBP5, MDD1, HTR2A, and MDD2. As in this study, the awareness of Saudi society about depression and its genetic and non-genetic causes was estimated. The results showed that an encouraging percentage of more than half of the research sample possessed correct information about this disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.sjbs.2022.103311

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Traditional genetic studies only partially account for the heterogeneity and environmental sensitivity of major depressive disorder.
“Traditional genetic studies have identified heritable components of major depressive disorder (MDD), but they only partially account for its heterogeneity and sensitivity to environmental influences (Alshaya, 2022).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Alshaya, 2022

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.
Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,462 · see citing works
Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic
Ettman, C. K., Abdalla, S. M., Cohen, G. H., Sampson, L., Vivier, P. M., & Galea, S. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19686 · Cited by 2,138 · see citing works
Epigenetics and gene expression
Gibney, E. R., & Nolan, C. M. (2010) · Heredity · doi:10.1038/hdy.2010.54 · Cited by 1,109 · see citing works
Epigenetics and environmental chemicals
Baccarelli, A., & Bollati, V. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32832925cc · Cited by 939 · see citing works
Major depressive disorder: new clinical, neurobiological, and treatment perspectives
Kupfer, D. J., Frank, E., & Phillips, M. L. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60602-8 · Cited by 894 · see citing works
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
Guo, J. U., Su, Y., Shin, J. H., Shin, J., Li, H., Xie, B., Zhong, C., Hu, S., Le, T., Fan, G., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3607 · Cited by 714 · see citing works
Environmental epigenetics
Bollati, V, & Baccarelli, A. (2010) · Heredity · doi:10.1038/hdy.2010.2 · Cited by 590 · see citing works
The Prevalence and National Burden of Treatment-Resistant Depression and Major Depressive Disorder in the United States
Zhdanava, M., Pilon, D., Ghelerter, I., Chow, W., Joshi, K., Lefebvre, P., & Sheehan, J. J. (2021) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.20m13699 · Cited by 523 · see citing works
Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability
El-Hack, M. E. A., El‐Saadony, M. T., Swelum, A. A., Arif, M. A., Ghanima, M. M. A., Shukry, M., Noreldin, A. E., Taha, A. E.-S., & El-Tarabily, K. A. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11372 · Cited by 396 · see citing works
Molecular studies of major depressive disorder: the epigenetic perspective
Mill, J. S., & Petronis, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001992 · Cited by 302 · see citing works
Genetics Factors in Major Depression Disease
Shadrina, M. I., Bondarenko, E. A., & Slominsky, P. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00334 · Cited by 300 · see citing works
The neurobiology of depression
Palazidou, E. (2012) · British Medical Bulletin · doi:10.1093/bmb/lds004 · Cited by 288 · see citing works
Role of Epigenetics in Biology and Human Diseases.
Moosavi, A., & Ardekani, A. M. (2016) · PubMed Central · doi:10.22045/ibj.2016.01 · Cited by 285 · see citing works
Tapering of SSRI treatment to mitigate withdrawal symptoms
Horowitz, M. A., & Taylor, D. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30032-x · Cited by 280 · see citing works
Epigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works
The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 269 · see citing works
Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress
Gold, P. W., Machado-Vieira, R., & Pavlatou, M. G. (2015) · Neural Plasticity · doi:10.1155/2015/581976 · Cited by 259 · cited 1× · see citing works
“The World Health Organization has classified this disorder as the 4th leading etiology of disability globally (Andrey and Jaime, 2009; Kupfer et al., 2012; Gold et al., 2015).”
Background
Antioxidant and antimicrobial activities of Spirulina platensis extracts and biogenic selenium nanoparticles against selected pathogenic bacteria and fungi
Abdel-Moneim, A.-M. E., El-Saadony, M. T., Shehata, A. M., Saad, A. M., Aldhumri, S. A., Ouda, S. M., & Mesalam, N. M. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.09.046 · Cited by 229 · see citing works
Epigenetic mechanisms of depression
Nestler, E. J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4291 · Cited by 217 · see citing works
Editorial (Thematic Selection: A Systematic Review of Depression)
Cui, R. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831123535 · Cited by 213 · see citing works
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
The Developing Genome: An Introduction to Behavioral Epigenetics
(2015) · Scholarship @ Claremont (The Claremont Colleges) · Cited by 176 · see citing works
A review of DNA methylation in depression
Chen, D., Meng, L., Pei, F., Zheng, Y., & Leng, J. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.05.022 · Cited by 154 · see citing works
Nutritional Aspects and Health Benefits of Bioactive Plant Compounds against Infectious Diseases: A Review
El‐Saadony, M. T., Zabermawi, N. M., Zabermawi, N. M., Burollus, M. A., Shafi, M. E., Alagawany, M. M., Yehia, N., Askar, A. M., Alsafy, S. A., Noreldin, A. E., et al. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1944183 · Cited by 152 · see citing works
Selenium nanoparticles from Lactobacillus paracasei HM1 capable of antagonizing animal pathogenic fungi as a new source from human breast milk
El‐Saadony, M. T., Saad, A. M., Taha, T. F., Najjar, A., Zabermawi, N. M., Nader, M. M., AbuQamar, S. F., El-Tarabily, K. A., & Salama, A. A. A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.07.059 · Cited by 145 · see citing works
Epigenetic Regulations in Neuropsychiatric Disorders
Kuehner, J. N., Bruggeman, E. C., Wen, Z., & Yao, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00268 · Cited by 137 · see citing works
Impacts of Supplementing Broiler Diets with Biological Curcumin, Zinc Nanoparticles and Bacillus licheniformis on Growth, Carcass Traits, Blood Indices, Meat Quality and Cecal Microbial Load
El-Hack, M. E. A., Alaidaroos, B. A., Farsi, R. M., Abou‐Kassem, D. E., El‐Saadony, M. T., Saad, A. M., Shafi, M. E., Albaqami, N. M., Taha, A. E.-S., & Ashour, E. A. (2021) · Animals · doi:10.3390/ani11071878 · Cited by 136 · see citing works
Epigenetics and depression: return of the repressed
Dalton, V. S., Kolshus, E., & McLoughlin, D. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.028 · Cited by 134 · see citing works
Childhood and Adolescent Anxiety and Depression: Beyond Heritability
Franić, S., Middeldorp, C. M., Dolan, C. V., Ligthart, L., & Boomsma, D. I. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.013 · Cited by 131 · see citing works
The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology
Yaqoob, M. U., El-Hack, M. E. A., Hassan, F., El‐Saadony, M. T., Khafaga, A. F., Batiha, G. E., Yehia, N., Elnesr, S. S., Alagawany, M. M., El-Tarabily, K. A., et al. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101143 · Cited by 127 · see citing works
Epigenetic Modifications of Major Depressive Disorder
Saavedra, K., Molina-Márquez, A., Saavedra, N., Zambrano, T., & Salazar, L. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081279 · Cited by 124 · see citing works
Use of biological nano zinc as a feed additive in quail nutrition: biosynthesis, antimicrobial activity and its effect on growth, feed utilisation, blood metabolites and intestinal microbiota
Reda, F. M., El‐Saadony, M. T., El-Rayes, T. K., Attia, A. I., El-Sayed, S. A. A., Ahmed, S. Y. A., Madkour, M., & Alagawany, M. M. (2021) · Italian Journal of Animal Science · doi:10.1080/1828051x.2021.1886001 · Cited by 114 · see citing works
The beneficial impacts of dietary phycocyanin supplementation on growing rabbits under high ambient temperature
Abdelnour, S. A., Swelum, A. A., Salama, A. A. A., Al‐Ghadi, M. Q., Qattan, S. Y. A., El-Hack, M. E. A., Khafaga, A. F., Alhimaidi, A. R., Almutairi, B. O., Ammari, A. A., et al. (2020) · Italian Journal of Animal Science · doi:10.1080/1828051x.2020.1815598 · Cited by 102 · see citing works
Dietary effect of licorice (Glycyrrhiza glabra) on quail performance, carcass, blood metabolites and intestinal microbiota
Reda, F. M., El‐Saadony, M. T., El-Rayes, T. K., Farahat, M. H., Attia, G., & Alagawany, M. M. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101266 · Cited by 102 · see citing works
Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental
Bennabi, D., Charpeaud, T., Yrondi, A., Genty, J., Destouches, S., Lancrenon, S., Allaïli, N., Bellivier, F., Bougerol, T., Camus, V., et al. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2237-x · Cited by 101 · see citing works
Various forms of depression
Benazzi, F. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.2/fbenazzi · Cited by 93 · cited 2× · see citing works
“The term depression refers to a broad spectrum of overlapping mental disorders that are categorized via the (Diagnostic and Statistical Manual of Mental Disorders) according to the severity of depression and its associated features and are distributed into many types varying from bipolar I depression to major depressi…”
Background
Mitigating negative impacts of heat stress in growing rabbits via dietary prodigiosin supplementation
Abdelnour, S. A., El‐Saadony, M. T., Saghir, S. A. M., El-Hack, M. E. A., Alshargi, O., Al-Gabri, N. A., & Salama, A. A. A. (2020) · Livestock Science · doi:10.1016/j.livsci.2020.104220 · Cited by 92 · see citing works
Prebiotics can restrict Salmonella populations in poultry: a review
El-Hack, M. E. A., El‐Saadony, M. T., Shafi, M. E., Alshahrani, O. A., Saghir, S. A. M., Al-wajeeh, A. S., Alshargi, O., Taha, A. E.-S., Mesalam, N. M., & Abdel‐Moneim, A. E. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1883637 · Cited by 90 · see citing works
Biochemical and Functional Characterization of Kidney Bean Protein Alcalase-Hydrolysates and Their Preservative Action on Stored Chicken Meat
Saad, A. M., Sitohy, M. Z., Ahmed, A. I., Rabie, N. A., Amin, S. A., Aboelenin, S. M., Soliman, M. M., & El‐Saadony, M. T. (2021) · Molecules · doi:10.3390/molecules26154690 · Cited by 89 · see citing works
Paenibacillus polymyxa (LM31) as a new feed additive: Antioxidant and antimicrobial activity and its effects on growth, blood biochemistry, and intestinal bacterial populations of growing Japanese quail
Alagawany, M. M., Madkour, M., El‐Saadony, M. T., & Reda, F. M. (2021) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2021.114920 · Cited by 75 · see citing works
Enhancing quality and safety of raw buffalo meat using the bioactive peptides of pea and red kidney bean under refrigeration conditions
El‐Saadony, M. T., El-Hack, M. E. A., Swelum, A. A., Al-Sultan, S. I., El‐Ghareeb, W. R., Hussein, E. O., Ba-Awadh, H. A., Akl, B. A., & Nader, M. M. (2021) · Italian Journal of Animal Science · doi:10.1080/1828051x.2021.1926346 · Cited by 75 · see citing works
International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets
Caraci, F., Calabrese, F., Molteni, R., Bartova, L., Dold, M., Leggio, G. M., Fabbri, C., Mendlewicz, J., Racagni, G., Kasper, S. F., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014977 · Cited by 73 · see citing works
Bioactive peptides supplemented raw buffalo milk: Biological activity, shelf life and quality properties during cold preservation
El‐Saadony, M. T., Khalil, O. S. F., Osman, A., Alshilawi, M. S., Taha, A. E.-S., Aboelenin, S. M., Shukry, M., & Saad, A. M. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.04.065 · Cited by 72 · see citing works
Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 65 · see citing works
Impact of cucumber pomace fortification on the nutritional, sensorial and technological quality of soft wheat flour‐based noodles
Saad, A. M., El‐Saadony, M. T., Mohamed, A. S., Ahmed, A. I., & Sitohy, M. Z. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14970 · Cited by 65 · see citing works
Effects of Chemical and Natural Additives on Cucumber Juice’s Quality, Shelf Life, and Safety
El‐Saadony, M. T., Elsadek, M. F., Mohamed, A. S., Taha, A. E.-S., Ahmed, B. M., & Saad, A. M. (2020) · Foods · doi:10.3390/foods9050639 · Cited by 64 · see citing works
Genetic and Epigenetic Consequence of Early-Life Social Stress on Depression: Role of Serotonin-Associated Genes
Soga, T., Teo, C. H., & Parhar, I. S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.601868 · Cited by 47 · see citing works
An Overview of Genome-Wide Association Studies
Chang, M., He, L., & Cai, L. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7717-8_6 · Cited by 47 · see citing works
Flavoring and extending the shelf life of cucumber juice with aroma compounds-rich herbal extracts at 4 °C through controlling chemical and microbial fluctuations
El‐Saadony, M. T., Saad, A. M., Elakkad, H. A., El-Tahan, A. M., Alshahrani, O. A., Alshilawi, M. S., El-Sayed, H. M., Amin, S. A., & Ahmed, A. I. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.08.092 · Cited by 41 · see citing works
Neural and behavioral epigenetics; what it is, and what is hype
Isles, A. R. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12184 · Cited by 36 · see citing works
Chickpea (Cicer arietinum) steep liquor as a leavening agent: Effect on dough rheology and sensory properties of bread
Saad, A. M., Elmassry, R. A., Wahdan, K. M. M., & Ramadan, F. (2015) · Acta periodica technologica · doi:10.2298/apt1546091s · Cited by 35 · see citing works
Effects of Genes and Stress on the Neurobiology of Depression
Mann, J. J., & Currier, D. (2006) · International review of neurobiology · doi:10.1016/s0074-7742(06)73005-7 · Cited by 32 · see citing works
Unipolar depressive disorders have a common genotype
Edvardsen, J., Torgersen, S. O., Røysamb, E., Lygren, S., Skre, I., Onstad, S., & Øien, P. A. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.004 · Cited by 31 · see citing works
Treatment-Resistant Depression in Poland—Epidemiology and Treatment
Gałecki, P., Samochowiec, J., Mikułowska, M., & Szulc, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030480 · Cited by 31 · see citing works
Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation
Zahavi, A. Y., Sabbagh, M. A., Washburn, D., Mazurka, R., Bagby, R. M., Strauss, J., Kennedy, J. L., Ravindran, A. V., & Harkness, K. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150872 · Cited by 23 · see citing works
Mixed Depression: A Mini-Review to Guide Clinical Practice and Future Research Developments
Natale, A., Mineo, L., Fusar‐Poli, L., Aguglia, A., Rodolico, A., Tusconi, M., Amerio, A., Serafini, G., Amore, M., & Aguglia, E. (2022) · Brain Sciences · doi:10.3390/brainsci12010092 · Cited by 22 · see citing works
Epigenetics, chromatin and brain development and function
Isles, A. R. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818812011 · Cited by 15 · see citing works
Computational Systems Biology
Tum, W., & Dong, A. (2018) · Methods in Molecular Biology · doi:10.1007/978-1-4939-7717-8 · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

National Collaborating Centre for Mental Health (UK), 2010. The management of subthreshold depressive symptoms. In Depression: The Treatment and Management of Depression in Adults (Updated Edition). British Psychological Society. 22132433
Shadrina, M. Bondarenko E.A. Slominsky P.A. Genetics factors in major depression disease‏ Frontiers in psychiatry 9 2018 334 30083112 PMC6065213

Sorted by citations

Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options
Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 164 · see citing works
Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review
Sălcudean, A., Bodo, C.-R., Popovici, R. A., Lica, M. M., Păcurar, M., Crăciun, R.-E., Crișan, A., ENĂTESCU, V. R., Marinescu, I. P., Cîmpian, D. M., et al. (2025) · Biomolecules · doi:10.3390/biom15040502 · Cited by 165 · see citing works
Gut microbiome-gut brain axis-depression: interconnection
Patel, R. A., Panche, A. N., & Harke, S. N. (2024) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2024.2436854 · Cited by 43 · see citing works
From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation
Krasner, H., Ong, C. V., Hewitt, P., & Vida, T. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073219 · Cited by 36 · see citing works
Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue
Lages, Y., & McNaughton, N. (2022) · Personality Neuroscience · doi:10.1017/pen.2022.4 · Cited by 28 · see citing works
Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies
Aljabali, A. A. A., Alkaraki, A. K., Gammoh, O., Tambuwala, M. M., Mishra, V. K., Mishra, Y., Hassan, S. S., & El‐Tanani, M. (2024) · Biology · doi:10.3390/biology13080638 · Cited by 26 · see citing works
Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options
Han, W., Wang, N., Han, M., Ban, M., Sun, T., & Xu, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1029495 · Cited by 18 · see citing works
The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review
Zhang, Y., Yue, W., & Li, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05717-z · Cited by 15 · see citing works
The Potential of Selected Plants and Their Biologically Active Molecules in the Treatment of Depression and Anxiety Disorders
Urbanská, N., Ashaolu, T. J., Mattova, S., Simko, P., & Kisková, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052368 · Cited by 14 · see citing works
Resilience to depression: the role of benevolent childhood experiences in a South African sample
Somefun, O. D., Theron, L. C., Höltge, J., & Ungar, M. T. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1209504 · Cited by 11 · see citing works
Explaining association between interpersonal communication competence and depression through need satisfaction, anxiety, and stress
Çıkrıkçı, N. (2024) · Current Psychology · doi:10.1007/s12144-024-06250-8 · Cited by 15 · see citing works
Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View
Sahay, S., Pulvender, P., Reddy, M. V. S. R. R., McCullumsmith, R. E., & O'Donovan, S. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158266 · Cited by 10 · see citing works
Kif15 deficiency contributes to depression-like behavior in mice
Wang, J., Tu, Q., Zhang, S., He, X., Ma, C., Qian, X., Wu, R., Shi, X., Yang, Z., Liu, Y., et al. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01238-y · Cited by 9 · see citing works
A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans
Castro, S. C. C., Bicca, C., Bicca, B., Araujo, S., & Viola, T. W. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1143332 · Cited by 11 · see citing works
Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis
Xue, H., Chen, J., & Fan, W. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.006 · Cited by 8 · see citing works
Screening of DNMT3A inhibitors from phytochemicals using molecular docking and molecular dynamics simulation for their anti-cancer potential
Kour, S., Prabhu, D., Biswas, I., Singh, A., Pawar, S. C., Perugu, S., & Vuree, S. (2024) · Molecular Simulation · doi:10.1080/08927022.2024.2376333 · Cited by 8 · see citing works
Tea and Its Active Ingredients in Preventing and Alleviating Depression: A Comprehensive Review
Xiao, S., Li, Y., Jiang, H., Hou, S., Wang, Y., Wang, D., & Teng, J. (2025) · Foods · doi:10.3390/foods14122054 · Cited by 10 · see citing works
Proteomic profiling of human plasma for anxiety and depression: Discovery of potential biomarkers and mechanistic insights
Ding, C., Qi, W., Tu, H., Wang, Y., Zhang, T., & Sun, H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120067 · Cited by 9 · see citing works
Hormonal Underpinnings of Emotional Regulation: Bridging Endocrinology and Psychology
Yılmazer, E. (2024) · üha · doi:10.32739/uha.jnbs.11.1539123 · Cited by 16 · see citing works
Associations between violence in childhood, depression and suicide attempts in adolescence: evidence from a cohort study in Luwero district, Uganda
Akunzirwe, R., Carter, D. J., Hanna, L., Zinke-Allmang, A., Akim, A., Datzberger, S., Parkes, J., Knight, L., Atuhaire, L., Nakuti, J., et al. (2024) · BMC Public Health · doi:10.1186/s12889-024-20950-7 · Cited by 8 · see citing works
The 3 Ds: Depression, Dysbiosis, and Clostridiodes difficile
Boustany, A., Feuerstadt, P., & Tillotson, G. (2024) · Advances in Therapy · doi:10.1007/s12325-024-02972-0 · Cited by 7 · see citing works
Probiotics as technological innovations in psychiatric disorders: patents and research reviews
de Lima, A. A., Santos, S. S., de Araújo, M. A., Vinderola, G., Villarreal, C. F., & Viana, M. D. M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1567097 · Cited by 7 · see citing works
The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature
Astorino, M. F., Calabrò, M., Infortuna, C., Muscatello, M. R. A., Briuglia, S., Cicero, N., Fabbri, C., Serretti, A., & Crisafulli, C. (2025) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.33045 · Cited by 8 · see citing works
Current drug targets for the treatment of depression
Pathak, G., Nigade, A., Anitha, K., & Bhatt, S. (2025) · Brain Disorders · doi:10.1016/j.dscb.2025.100270 · Cited by 7 · see citing works
Depression and suicidal ideation among adolescent girls in refugee settlements in northern Uganda
Otika, D., Odongo, G. Y., Muzaki, R. M. M., Lamwaka, B. O., Bongomin, F., & Pebolo, P. F. (2024) · Medicine · doi:10.1097/md.0000000000038077 · Cited by 7 · see citing works
Novel Insights into Dietary Bioactive Compounds and Major Depressive Disorders: Evidence from Animal Studies and Future Perspectives
Shen, C., Hassan, T., Presto, P., Payberah, D., Devega, R., Wakefield, S. M., Dunn, D. M., & Neugebauer, V. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.006 · Cited by 8 · see citing works
Molecular mechanisms and risk factors in rheumatoid arthritis: a comprehensive review
Kumar, A., Singh, S., Goel, F., Pandey, R. K., Singh, L., Kumar, A., & Dobhal, V. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02073-6 · Cited by 6 · see citing works
Serotonergic-dependent effects of exercise and elevated stress hormone on small non-coding RNA transcriptomics and proteomics in a mouse model of affective disorders
Ma, K., Wilson, C., Cheng, L., Pang, T. Y., Li, S., Roberts, B. R., Lago, L., Tran, H., Hill, A. F., Hannan, A. J., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110240 · Cited by 6 · see citing works
Effects of Fzd6 on intestinal flora and neuroinflammation in lipopolysaccharide-induced depression-like mice
Chen, W., Yan, X., Song, X., Yang, Y., Wang, X., Xu, G., Wang, T., Liu, Y., Zhao, F., & Song, G. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.12.011 · Cited by 6 · see citing works
Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression
Sun, S., Kong, L., Hu, F., Wang, S., Geng, M., Cao, H., Tao, X., Tao, F., & Liu, K. (2024) · Metabolites · doi:10.3390/metabo14120689 · Cited by 5 · see citing works
Five-Year Trends in SSRI Consumption: A Precision Medicine Approach to Comparative Analysis Between Serbia and European Countries
Samardžić, J., Simović, F., Sekanić, K., & Branković, M. (2025) · Healthcare · doi:10.3390/healthcare13101174 · Cited by 6 · see citing works
Clinical study on the modulating effects of Jiaotaiwan on the microbiota–SCFAs–neurotransmitter/immune axis in patients with depression
Yang, T., He, Y., Huang, M., Liu, Y., Liu, F., Li, Y., Gao, S., Shen, L., Xu, Q., & Yu, C. (2025) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000174 · Cited by 5 · see citing works
Genetic and Epigenetic Factors Associated with Postpartum Psychosis: A 5-Year Systematic Review
Tsokkou, S., Kavvadas, D., Georgaki, M.-N., Papadopoulou‐Legbelou, K., Papamitsou, T., & Karachrysafi, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13040964 · Cited by 5 · see citing works
Gene expression and brain imaging association study reveals gene signatures in major depressive disorder
Liu, W., Su, J.-P., Zeng, L., Shen, H., & Hu, D. (2024) · Brain Communications · doi:10.1093/braincomms/fcae258 · Cited by 5 · see citing works
Association between fluoride exposure and psychiatric disorders in adults
Yu, F., Luo, K., Wang, G., Zhao, C.-Y., Wang, M., Li, Q., Sha, T., Dong, Z.-C., Zhou, G., Ba, Y., et al. (2024) · International Journal of Environmental Health Research · doi:10.1080/09603123.2024.2378950 · Cited by 5 · see citing works
Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook
Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works
“Traditional genetic studies have identified heritable components of major depressive disorder (MDD), but they only partially account for its heterogeneity and sensitivity to environmental influences (Alshaya, 2022).”
Curcumin and exercise prevent depression via alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats
Ahmadi, E., Pourmotabbed, A., Aghaz, N., Nedaei, S. E., Veisi, M., Salimi, Z., Zarei, F., Jalili, C., Moradpour, F., & Zeinivand, M. (2024) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_94_23 · Cited by 4 · see citing works
Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression
Bumrungthai, S., Buddhisa, S., Duangjit, S., Passorn, S., Sumala, S., & Prakobkaew, N. (2024) · Biomedical Reports · doi:10.3892/br.2024.1869 · Cited by 4 · see citing works
Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential
Tudorancea, I.-M., Stanciu, G. D., Torrent, C., Madero, S., Hriţcu, L., & Tamba, B.-I. (2025) · Dialogues in Clinical Neuroscience · doi:10.1080/19585969.2025.2499458 · Cited by 4 · see citing works
Mental Health Sequelae of Cardiac Events: A Comprehensive Review of Biological Mechanisms, Prevalence, and Interdisciplinary Care Approaches
Oishe, O. F., Islam, S. T., Pakrad, P., Chikatimalla, R., & Jain, R. (2025) · Cardiology in Review · doi:10.1097/crd.0000000000000924 · Cited by 3 · see citing works
Associations between dairy and alcohol consumption and major depressive disorder in a mendelian randomization study
Qiu, D., Song, R., Cao, X., Tian, Y., Cheng, X., Sun, D., Cai, S., Wang, Z., & Zhang, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-80330-4 · Cited by 2 · see citing works
Aqueous and Ethanol Extracts of Acacia sieberiana (Fabaceae) Stem Bark Reverse the Pain–Depression Dyad in Mice Through Modulation of Catecholamines, Proinflammatory Cytokines, and Oxidative Stress
Ngassam, S. M., Fokoua, A. R., Koho, C. W., Foguieng, R. H. S., Tabatabaei, S. M., Nankam, P. A. N., Tidgewell, K. J., & Nguelefack, T. B. (2025) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/1244498 · Cited by 2 · see citing works
Assessing Peer Exposure at a Group Level: The Role of Mild‐to‐Moderate Symptoms in the Transmission of Mental Health Problems
Liu, D., Wei, X., Jia, L., Huang, S., & Bao, Z. (2025) · Depression and Anxiety · doi:10.1155/da/1787378 · Cited by 2 · see citing works
Exploring the relationship between atenolol use and depression: A network pharmacology approach using NHANES data
Cao, Y., Wang, Z., & Li, Y. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119675 · Cited by 2 · see citing works
Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders
Chenchula, S., Shubham, A., Rozatkar, A. R., Modak, T., Komal, K., Jhaj, R., Jitendra, S., Satyaprakash, V., & Sadasivam, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1697866 · Cited by 2 · see citing works
Prevalence of depression among oocyte donor candidates: a systematic review and meta-analysis
Rashidian, P., Amini‐Salehi, E., Ahmadi, S., & Salehi, S. A. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000004523 · Cited by 2 · see citing works
Genetic signatures of suicide attempt behavior: insights and applications
Drago, A. (2024) · Expert Review of Proteomics · doi:10.1080/14789450.2024.2314143 · Cited by 2 · see citing works
Ketamine and epigenetic processes in depression, intersection between serotonergic and glutamatergic pathways
Nepton, A., Farahani, H., Williams, M. T., Booij, L., & Faber, S. C. (2024) · Journal of Psychedelic Studies · doi:10.1556/2054.2024.00343 · Cited by 2 · see citing works
A modified persian version of the self-stigma of depression scale among the Iranian population: a methodological study in 2023
Jafari, A., Moshki, M., Naddafi, F., Lael–Monfared, E., & Nejatian, M. (2024) · BMC Psychology · doi:10.1186/s40359-024-01802-w · Cited by 5 · see citing works
DSP-6745, a novel 5-hydroxytryptamine modulator with rapid antidepressant, anxiolytic, antipsychotic and procognitive effects
Kitaichi, M., KATO, T., Oki, H., Tatara, A., Kawada, T., Miyazaki, K., Ishikawa, C., Kaneda, K., & Shimizu, I. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06629-2 · Cited by 2 · see citing works
Unraveling the Triad: A Bioinformatics Analysis of the Interplay between Prenatal Depression, Inflammation, and the Gut Microbiota
Taha, W., Anachad, O., Assioui, H., Saadoune, C., Taheri, A., Messal, M. E., Bennis, F., & Chegdani, F. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273371682250421053159 · Cited by 2 · see citing works
Exploring the applications of molecularly imprinted polymers in drug delivery to the nervous system
Pourbala, H., Peyvand, F., Izadi, S., Ashtiani, S. J., Rabbanian, D., Pouyanfar, N., Banan, K., Shahbazi, M., Faizi, M., & Ghorbani‐Bidkorbeh, F. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107718 · Cited by 1 · see citing works
Advances in antidepressant pharmacotherapy: phase 3 evidence and clinical perspectives
Cuomo, A., Pinzi, M., & Fagiolini, A. M. (2026) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2026.2634195 · Cited by 1 · see citing works
Genotype-stratified Default Mode Network hyperconnectivity in major depressive disorder: an MR imaging genetics study
Singh, P., Singh, S., Peer, S., Ludhiadch, A., Singh, J., Kaur, H., & Munshi, A. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121751 · Cited by 1 · see citing works
Transforming depression research: The role of artificial intelligence and computational modelling
Somkuwar, S. S., Hussain, U., Sahu, D. C., Sheikh, D. M. T., Sheikh, S. M., Gautam, M. M., Meshram, S. S., & Belgamwar, V. S. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100492 · Cited by 1 · see citing works
base genética de los trastornos depresivos
Gutiérrez, J., & Garcı́a, P. (2024) · Ambiociencias · doi:10.18002/ambioc.i21.8180 · Cited by 1 · see citing works
Enhanced Depression Detection on Social Media Using Advanced Machine Learning and Linguistic Analysis Techniques
Patil, J., Patil, V., Prajapati, K., Patel, D., Trivedi, S., & Patel, R. (2025) · Lecture notes in networks and systems · doi:10.1007/978-981-96-1264-2_23 · Cited by 1 · see citing works
Association Analysis of Gene Expression and Brain Image Identifies Gene Signatures in Major Depression Disorder
Liu, W., Su, J., & Zeng, L. (2023) · Communications in computer and information science · doi:10.1007/978-981-99-2789-0_13
Epigenetic programming of human disease and aging
Rivero-Segura, N. A., Castro-Morales, D., Beristain-Pozos, J. D., Sandoval-Rodríguez, F. E., & Gómez-Verján, J. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21863-7.00017-2
Estimate the Prevalence of Depression in Type 2 Diabetes Patients
AL-Khaqani, Z. M. H., & Al-Turaihi, T. (2024) · Kufa Medical Journal · doi:10.36330/kmj.v20i1.16115
Depression
Gamlin, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-38971-9_175-1
Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN
Amin, M., & Gragnoli, C. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02014-y
Analysis of Human Reproductive Dynamics
Santosh, K., & Roy, D. G. (2025) · Studies in computational intelligence · doi:10.1007/978-981-95-1248-5_2
Nanotechnology-Enhanced MicroRNAs for Improved Diagnosis and Treatment of Major Depressive Disorder: A Comprehensive Review
Shareef, A., Sameer, H. N., Yaseen, A., Athab, Z. H., Adil, M., & Allela, O. Q. B. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05459-3
Ripple Effect: The Role of Climate Change Anxiety, Nature Connectedness, and Pro-environmental Behavior in Building Climate Resilience and Mitigating Psychological Distress Among Flood-Affected and Non-affected Youth
Awan, M., Gul, I., Aleem, S., & Ahmed, M. (2025) · Advances in global change research · doi:10.1007/978-3-032-04141-8_16
Diabetes-Induced depression: A molecular perspective
Hedayati‐Moghadam, M., Razazpour, F., Mirzaee, F., Hakemi, Z., Dalfardi, M., & Baghcheghi, Y. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01806-2
Mental health across the lifecourse as predictors of epigenetic aging from a longitudinal birth cohort in the United States
Jones, R., Clausing, E. S., Shelton, R. C., Conneely, K. N., Prada, D., Factor-Litvak, P. R., Cirillo, P. M., Baccarelli, A., Cohn, B. A., Keyes, K. M., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120962
Life cycle benzophenone 1 exposure induces anxiety- and depression-like behaviors in zebrafish via endoplasmic reticulum stress-mediated dopaminergic system dysfunction
Qi, Z., Li, P. P., Gao, X., Wu, Q., Li, K., Xie, Z., Xia, X., Wang, T., Zhou, X., Li, J., et al. (2026) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2026.01.008
Carvacrol mitigates chronic social isolation stress–induced depressive-like phenotypes via Nrf2-dependent antioxidant defense and downregulation of NF-κB proinflammatory pathway
Ameer, M. K., Ullah, N., Qazi, N. G., Ahmad, H. A., Mehboob, F., Badshah, I., & Khan, M. F. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119258
Nonlinear threshold and association of depressive symptoms with pain in middle-aged and older Chinese adults: a cross-sectional and cohort study
Zhang, J., Yi, L., Yu, H., & Yang, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-44220-1
Depressive symptomatology in women and association with socioeconomic, clinical, and behavioral characteristics
Angarita, D. M. P., Miguez, F. G. G., & Leite, F. M. C. (2026) · Acta Paulista de Enfermagem · doi:10.37689/acta-ape/2026ao0000561i
Depression and breast cancer: research progress and prospects from an interdisciplinary perspective
He, K., Tang, H., Mai, C., Li, Y., & Yu, D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760846
BDNF and GSK-3β signaling in depression: molecular mechanisms underlying neural plasticity dysfunction
Al‐kuraishy, H. M., Abass, S. A., Mahana, H. A. M., Elbanna, O. A., Shahin, I., Radwan, A. A., MohamedMohamed, O. E.-S., Baktoot, A. M. L., & Batiha, G. E. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12110-4
Unpacking adolescent depression: A narrative review from a transdiagnostic perspective using the dimensional RDoC framework
Bellmont-Olson, L. M., Wright, M., Müller‐Oehring, E. M., Baker, F. C., Kiss, O., Pohl, K. M., Gotlib, I. H., & Schulte, T. (2026) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2026.101129
Comparative evaluation of two chronic stress models in zebrafish for advancing depression research
Tripathy, C., Dhaygude, S. S., Vijay, V., Mondal, A., Soren, K., Kumar, A. T. R., & Chakravarty, S. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115453
Mental health and burnout among Swiss medical students living in contexts of deprivation: a longitudinal study
Chardon, M., Bodenmann, P., Carrard, V., Berney, A., & Grazioli, V. S. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-114025
Epigenetic dysregulation in depression: molecular mechanisms, clinical biomarkers, and therapeutic opportunities
Li, J., Guan, X., Zhang, R., & Zhang, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08772-0
Potential role of 5-HT7 receptor antagonists in the treatment of depression: Pharmacological and bioengineering perspectives
Dhar, A. K., Keswani, R., Anitha, K., Pathak, G., Nigade, A., & Bhatt, S. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111915
Integrating Environmental Exposures, Epigenetic Programming and Nanotechnology for Chronic Disease Prevention in the One Health Era
Gonçalves, P. S. T., & Backx, B. P. (2026) · International Journal of Environmental Medicine · doi:10.3390/ijem1030016
Association of residential greenspace with incident depression: a prospective cohort study
Yang, C., Lan, T., Zhai, Y., Liu, B., Hu, F., & Ba, J. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1897674
The Interplay Between Depression and Cardiovascular Disease: Mechanisms, Clinical Implications, and Emerging Therapeutic Perspectives
Souri, H., Koopaei, M., Garavand, A., & Souri, F. (2026) · Current Cardiology Reports · doi:10.1007/s11886-026-02442-9

Authors: Alshaya, D. S.
Affiliations: Princess Nourah bint Abdulrahman University (SA)
Corresponding author: Alshaya, Dalal S.
ORCID: Alshaya, Dalal S.
Venue: Saudi Journal of Biological Sciences
Publisher: Elsevier BV
Published: 2022-08
Volume: 29
Issue: 8
Pages: 103311
ISSN: 1319-562X (ISSN-L)
DOI: 10.1016/j.sjbs.2022.103311
PMC: PMC9232544
OpenAlex: W4280530400
Cited by: 81
References: 60
Citations by year: 2026: 18 · 2025: 28 · 2024: 27 · 2023: 6 · 2022: 2
FWCI: 2.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Saudi Journal of Biological Sciences (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Princess Nourah Bint Abdulrahman University
Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: depression, genetic factors, epigenetic factors, DNA methylation, histone modifications, non-coding RNA, serotonin transporter, catechol-O-methyltransferase, tryptophan hydroxylase 2, FKBP5, HTR2A, childhood abuse, environmental stress, depression awareness, Saudi society

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetic and epigenetic factors associated with depression: an updated overview

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks