Cited by 174Pain Mechanisms and TreatmentsPain Management and TreatmentNeuroinflammation and Neurodegeneration Mechanisms

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Targeting cytokines for treatment of neuropathic pain

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Hung, Alice L., Lim, Michael, Doshi, Tina L.·2017·Scandinavian Journal of Pain

DOI 10.1016/j.sjpain.2017.08.002PMC PMC5774983

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Abstract

BACKGROUND: Neuropathic pain is a challenging condition often refractory to existing therapies. An increasing number of studies have indicated that the immune system plays a crucial role in the mediation of neuropathic pain. Exploration of the various functions of individual cytokines in neuropathic pain will provide greater insight into the mechanisms of neuropathic pain and suggest potential opportunities to expand the repertoire of treatment options. METHODS: A literature review was performed to assess the role of pro-inflammatory and anti-inflammatory cytokines in the development of neuropathic pain. Both direct and indirect therapeutic approaches that target various cytokines for pain were reviewed. The current understanding based on preclinical and clinical studies is summarized. RESULTS AND CONCLUSIONS: In both human and animal studies, neuropathic pain has been associated with a pro-inflammatory state. Analgesic therapies involving direct manipulation of various cytokines and indirect methods to alter the balance of the immune system have been explored, although there have been few large-scale clinical trials evaluating the efficacy of immune modulators in the treatment of neuropathic pain. TNF-α is perhaps the widely studied pro-inflammatory cytokine in the context of neuropathic pain, but other pro-inflammatory (IL-1β, IL-6, and IL-17) and anti-inflammatory (IL-4, IL-10, TGF-β) signaling molecules are garnering increased interest. With better appreciation and understanding of the interaction between the immune system and neuropathic pain, novel therapies may be developed to target this condition.

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Authors: Hung, A. L., Lim, M., & Doshi, T. L.
Affiliations: Johns Hopkins University (US)
Corresponding author: Doshi, Tina L.
ORCID: Hung, Alice L.
Lim, Michael
Doshi, Tina L.
Venue: Scandinavian Journal of Pain
Publisher: Walter de Gruyter GmbH
Published: 2017-10-01
Volume: 17
Issue: 1
Pages: 287-293
ISSN: 1877-8860 (ISSN-L)
1877-8879
DOI: 10.1016/j.sjpain.2017.08.002
PMC: PMC5774983
OpenAlex: W2748786482
Cited by: 174
References: 118
Citations by year: 2026: 5 · 2025: 19 · 2024: 29 · 2023: 22 · 2022: 29 · 2021: 30 · 2020: 29 · 2019: 7 · 2018: 4
FWCI: 1.34
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Scandinavian Journal of Pain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (T32GM075774)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neuropathic pain, cytokines, inflammatory cytokines, anti-inflammatory cytokines, immune system, TNF-α, IL-1β, interleukin-6, IL-17, IL-10, TGF-beta, immunomodulation, analgesic treatment, cytokine-targeted therapy
MeSH terms: Animals, Humans, Inflammation, Neuralgia, Cytokines

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Targeting cytokines for treatment of neuropathic pain

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