Depressive disorders may more commonly be related to circadian phase delays rather than advances: Time will tell
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Delayed rhythms during adolescence and early adulthood are strongly associated with depression and the severity of mood symptoms.
“delayed rhythms during adolescence and early adulthood are strongly associated with depression and the severity of mood symptoms195,196”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [196]
Cites
Light Suppresses Melatonin Secretion in Humans
Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913 · see citing works
Self-citationAntidepressant and Circadian Phase-Shifting Effects of Light
Lewy, A. J., Sack, R. L., Miller, L. S., & Hoban, T. M. (1987) · Science · doi:10.1126/science.3798117 · Cited by 709 · see citing works
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Self-citationPhase Advance of the Circadian Sleep-Wake Cycle as an Antidepressant
Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W., & Gillin, J. C. (1979) · Science · doi:10.1126/science.227056 · Cited by 528 · see citing works
The circadian basis of winter depression
Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602425103 · Cited by 451 · see citing works
Self-citationThe Dim Light Melatonin Onset as a Marker for Orcadian Phase Position
Lewy, A. J., & Sack, R. L. (1989) · Chronobiology International · doi:10.3109/07420528909059144 · Cited by 418 · see citing works
Self-citationCircadian Time of Morning Light Administration and Therapeutic Response in Winter Depression
Terman, J. S., Terman, M., Lo, E.-S., & Cooper, T. B. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.69 · Cited by 366 · see citing works
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Self-citationCircadian rhythms in psychiatry
Halaris, A. E. (1984) · Psychiatry Research · doi:10.1016/0165-1781(84)90085-4 · Cited by 319 · see citing works
Circadian misalignment in major depressive disorder
Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.009 · Cited by 253 · see citing works
Self-citationMelatonin for the Treatment of Sleep Disturbances in Major Depressive Disorder
Dolberg, O. T., Hirschmann, S., & Grunhaus, L. J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1119 · Cited by 169 · see citing works
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Melatonin Entrains Free‐running Blind People According to a Physiological Dose‐response Curve
Lewy, A. J., Emens, J. S., Lefler, B. J., Yuhas, K., & Jackman, A. R. (2005) · Chronobiology International · doi:10.1080/07420520500398064 · Cited by 143 · see citing works
Self-citationMelatonin treatment of winter depression: a pilot study
Lewy, A. J., Bauer, V. K., Cutler, N. L., & Sack, R. L. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(97)00128-5 · Cited by 114 · see citing works
Self-citationAntidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome
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Self-citationMorning or night-time melatonin is ineffective in seasonal affective disorder
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Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Bunney, B. G., & Bunney, W. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.020 · Cited by 181 · see citing works
Photoperiodic and circadian bifurcation theories of depression and mania
Kripke, D. F., Elliott, J. A., Welsh, D. K., & Youngstedt, S. D. (2015) · F1000Research · doi:10.12688/f1000research.6444.1 · Cited by 48 · see citing works
Nota, J. A., Gibb, B. E., & Coles, M. E. (2014) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.28.2.134 · Cited by 18 · see citing works
- Authors
- Lewy, A. J.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Lewy, Alfred J.
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 11
- Issue
- 2
- Pages
- 117-118
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2166025791
- Cited by
- 18
- References
- 18
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- depressive disorders, circadian phase, circadian rhythm, circadian phase delay, circadian phase advance, sleep timing, depression
- MeSH terms
- Circadian Rhythm, Depressive Disorder, Humans, Melatonin, Sleep Disorders, Circadian Rhythm
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