Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder
Abstract
Objective Patients with idiopathic rapid eye movement sleep behaviour disorder (RBD) are at substantial risk for developing Parkinson's disease (PD) or related neurodegenerative disorders. Speech is an important indicator of motor function and movement coordination, and therefore may be an extremely sensitive early marker of changes due to prodromal neurodegeneration.Methods Speech data were acquired from 16 RBD subjects and 16 age- and sex-matched healthy control subjects. Objective acoustic assessment of 15 speech dimensions representing various phonatory, articulatory, and prosodic deviations was performed. Statistical models were applied to characterise speech disorders in RBD and to estimate sensitivity and specificity in differentiating between RBD and control subjects.Results Some form of speech impairment was revealed in 88% of RBD subjects. Articulatory deficits were the most prominent findings in RBD. In comparison to controls, the RBD group showed significant alterations in irregular alternating motion rates (p = 0.009) and articulatory decay (p = 0.01). The combination of four distinctive speech dimensions, including aperiodicity, irregular alternating motion rates, articulatory decay, and dysfluency, led to 96% sensitivity and 79% specificity in discriminating between RBD and control subjects. Speech impairment was significantly more pronounced in RBD subjects with the motor score of the Unified Parkinson's Disease Rating Scale greater than 4 points when compared to other RBD individuals.Conclusion Simple quantitative speech motor measures may be suitable for the reliable detection of prodromal neurodegeneration in subjects with RBD, and therefore may provide important outcomes for future therapy trials.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some of these linguistic deficits may occur preclinically in each of these neurodegenerative disorders.
“Some of these deficits may actually occur preclini cally in each of these disorders. 3,33-36”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [34]
Cites
(2007) · Cited by 6,530 · see citing works
The International Classification of Sleep Disorders
Daroff, R. B. (1991) · Neurology · doi:10.1212/wnl.41.1.160 · Cited by 5,025 · see citing works
Praat, a system for doing phonetics by computer
Boersma, P. (2002) · UvA-DARE (University of Amsterdam) · Cited by 4,417 · see citing works
The International Classification of Sleep Disorders: Diagnostic and Coding Manual
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-413_1 · Cited by 2,416 · see citing works
Motor Speech Disorders: Substrates, Differential Diagnosis, and Management
Duffy, J. R. (1995) · Cited by 1,892 · see citing works
Schenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996) · Neurology · doi:10.1212/wnl.46.2.388 · Cited by 1,083 · see citing works
Iranzo, Á., Molinuevo, J. L., Santamaría, J., Serradell, M., Martı́, M. J., Valldeoriola, F., & Tolosa, E. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70476-8 · Cited by 950 · see citing works
Speech Impairment in a Large Sample of Patients with Parkinson’s Disease
Ho, A. K., Iansek, R., Marigliani, C., Bradshaw, J. L., & Gates, S. (1999) · Behavioural Neurology · doi:10.1155/1999/327643 · Cited by 685 · see citing works
Boeve, B. F. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05115.x · Cited by 642 · see citing works
Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients
Iranzo, A., Fernández-Arcos, A., Tolosa, E., Serradell, M., Molinuevo, J. L., Valldeoriola, F., Gelpi, E., Vilaseca, I., Sánchez-Valle, R., Lladó, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089741 · Cited by 548 · see citing works
Rusz, J., Čmejla, R., Ruzickova, H., & Růžička, E. (2011) · The Journal of the Acoustical Society of America · doi:10.1121/1.3514381 · Cited by 498 · see citing works
Progression of Dysarthria and Dysphagia in Postmortem-Confirmed Parkinsonian Disorders
Müller, J., Wenning, G. K., Verny, M., McKee, A. C., Chaudhuri, К. R., Jellinger, K. A., Poewe, W. H., & Litvan, I. (2001) · Archives of Neurology · doi:10.1001/archneur.58.2.259 · Cited by 414 · see citing works
Predictors of dementia in Parkinson disease
Anang, J. B. M., Gagnon, J., Bertrand, J., Romenets, S. R., Latreille, V., Panisset, M., Montplaisir, J. Y., & Postuma, R. B. (2014) · Neurology · doi:10.1212/wnl.0000000000000842 · Cited by 379 · see citing works
Postuma, R., Lang, A.-E., Gagnon, J., Pelletier, A., & Montplaisir, J. (2012) · Brain : a journal of neurology · doi:10.1093/brain/aws093 · Cited by 352 · see citing works
Postuma, R. B., Bertrand, J., Montplaisir, J. Y., Desjardins, C., Vendette, M., Romenets, S. R., Panisset, M., & Gagnon, J. (2012) · Movement Disorders · doi:10.1002/mds.24939 · Cited by 307 · see citing works
Rusz, J., Čmejla, R., Tykalová, T., Růžičková, H., Klempíř, J., Majerová, V., Picmausová, J., Roth, J., & Růžička, E. (2013) · The Journal of the Acoustical Society of America · doi:10.1121/1.4816541 · Cited by 264 · see citing works
Postuma, R. B., Gagnon, J., Vendette, M., & Montplaisir, J. Y. (2009) · Brain · doi:10.1093/brain/awp244 · Cited by 261 · see citing works
REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features
Postuma, R. B., Gagnon, J., Vendette, M., Charland, K., & Montplaisir, J. Y. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.149195 · Cited by 242 · see citing works
Schenck, C. H., Montplaisir, J. Y., Frauscher, B., Högl, B., Gagnon, J., Postuma, R. B., Šonka, K., Jennum, P., Partinen, M., Arnulf, I., et al. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.02.016 · Cited by 236 · see citing works
Civier, O., Bullock, D. H., Max, L., & Guenther, F. H. (2013) · Brain and Language · doi:10.1016/j.bandl.2013.05.016 · Cited by 220 · see citing works
Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease
Romenets, S. R., Gagnon, J., Latreille, V., Panisset, M., Chouinard, S., Montplaisir, J. Y., & Postuma, R. B. (2012) · Movement Disorders · doi:10.1002/mds.25086 · Cited by 188 · see citing works
Sapir, S. (2014) · Journal of Speech Language and Hearing Research · doi:10.1044/2014_jslhr-s-13-0039 · Cited by 184 · see citing works
Harel, B. T., Cannizzaro, M. S., Cohen, H., Reilly, N., & Snyder, P. J. (2004) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2004.06.001 · Cited by 181 · see citing works
Automatic Evaluation of Articulatory Disorders in Parkinson’s Disease
Novotný, M., Rusz, J., Čmejla, R., & Růžička, E. (2014) · IEEE/ACM Transactions on Audio Speech and Language Processing · doi:10.1109/taslp.2014.2329734 · Cited by 158 · see citing works
Rusz, J., Bonnet, C., Klempíř, J., Tykalová, T., Baborová, E., Novotný, M., Rulseh, A. M., & Růžička, E. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7671-1 · Cited by 148 · see citing works
Characteristics of the Dysarthria of Multiple System Atrophy
Kluin, K. J., Gilman, S., Lohman, M., & Junck, L. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550060089021 · Cited by 80 · see citing works
Parkinson’s disease and REM sleep behavior disorder result in increased non-motor symptoms
Neikrug, A. B., Avanzino, J. A., Liu, L., Maglione, J. E., Natarajan, L., Corey‐Bloom, J., Palmer, B. W., Loredo, J. S., & Ancoli‐Israel, S. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.04.009 · Cited by 71 · see citing works
Gong, Y., Xiong, K., Mao, C., Shen, Y., Hu, W., Huang, J., Han, F., Chen, R., & Liu, C. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.12.021 · Cited by 67 · see citing works
Olfactory dysfunction in idiopathic REM sleep behavior disorder
Miyamoto, T., Miyamoto, M., Iwanami, M., Hirata, K., Kobayashi, M., Nakamura, M., & Inoue, Y. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2009.09.013 · Cited by 64 · see citing works
Effect of dopaminergic medication on speech dysfluency in Parkinson’s disease: a longitudinal study
Tykalová, T., Rusz, J., Čmejla, R., Klempíř, J., Růžičková, H., Roth, J., & Růžička, E. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1363-y · Cited by 63 · see citing works
Acoustic assessment of voice and speech disorders in Parkinson's disease through quick vocal test
Rusz, J., Čmejla, R., Růžičková, H., Klempíř, J., Majerová, V., Picmausová, J., Roth, J., & Růžička, E. (2011) · Movement Disorders · doi:10.1002/mds.23680 · Cited by 56 · see citing works
Grant, L. M., Richter, F., Miller, J. E., White, S. A., Fox, C., Zhu, C., Chesselet, M., & Ciucci, M. R. (2014) · Behavioral Neuroscience · doi:10.1037/a0035965 · Cited by 51 · see citing works
Preclinical Parkinson's disease
Tetrud, J. W. (1991) · Neurology · doi:10.1212/wnl.41.5_suppl_2.69 · Cited by 34 · see citing works
Skodda, S. (2012) · Neurodegenerative Disease Management · doi:10.2217/nmt.12.47 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Idiopathic REM sleep behaviour disorder and neurodegeneration — an update
Högl, B., Stefani, A., & Videnović, A. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.157 · Cited by 542 · see citing works
Hlavnička, J., Čmejla, R., Tykalová, T., Šonka, K., Růžička, E., & Rusz, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00047-5 · Cited by 326 · see citing works
Brabenec, L., Mekyska, J., Galáž, Z., & Rektorová, I. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1676-0 · Cited by 240 · see citing works
Ali, L., Zhu, C., Zhang, Z., & Liu, Y. (2019) · IEEE Journal of Translational Engineering in Health and Medicine · doi:10.1109/jtehm.2019.2940900 · Cited by 199 · see citing works
Voice changes in Parkinson’s disease: What are they telling us?
Ma, A., Lau, K. K., & Thyagarajan, D. E. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.12.029 · Cited by 171 · see citing works
Guidelines for Speech Recording and Acoustic Analyses in Dysarthrias of Movement Disorders
Rusz, J., Tykalova, T., Ramig, L. O., & Tripoliti, E. (2021) · Movement Disorders · doi:10.1002/mds.28465 · Cited by 170 · see citing works
Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD
Arora, S., Baig, F., Lo, C., Barber, T. R., Lawton, M., Zhan, A., Rolinski, M., Ruffmann, C., Klein, J. C., Rumbold, J., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006366 · Cited by 142 · see citing works
Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease
Rusz, J., Hlavnička, J., Novotný, M., Tykalová, T., Pelletier, A., Montplaisir, J. Y., Gagnon, J., Dušek, P., Galbiati, A., Marelli, S., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26085 · Cited by 133 · see citing works
Rusz, J., Hlavnička, J., Tykalová, T., Novotný, M., Dušek, P., Šonka, K., & Růžička, E. (2018) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2018.2851787 · Cited by 118 · see citing works
Speech and language markers of neurodegeneration: a call for global equity
García, A. M., de Leon, J., Tee, B. L., Blasi, D. E., & Gorno-Tempini, M. L. (2023) · Brain · doi:10.1093/brain/awad253 · Cited by 102 · see citing works
Cognitive determinants of dysarthria in Parkinson's disease: An automated machine learning approach
García, A. M., Arias‐Vergara, T., C. Vasquez‐Correa, J., Nöth, E., Schuster, M., Welch, A. E., Bocanegra, Y., Baena, A., & Orozco‐Arroyave, J. R. (2021) · Movement Disorders · doi:10.1002/mds.28751 · Cited by 77 · see citing works
Characteristics of motor speech phenotypes in multiple sclerosis
Rusz, J., Srpová, B., Růžičková, H., Novotný, M., Tykalová, T., Hlavnička, J., Uher, T., Vaněčková, M., Andělová, M., Novotná, K., et al. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.11.007 · Cited by 82 · see citing works
X-Vectors: New Quantitative Biomarkers for Early Parkinson's Disease Detection From Speech
Jeancolas, L., Petrovska‐Delacrétaz, D., Mangone, G., Benkelfat, B.-E., Corvol, J., Vidailhet, M., Lehéricy, S., & Benali, H. (2021) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2021.578369 · Cited by 75 · see citing works
Arora, S., Baghai-Ravary, L., & Tsanas, A. (2019) · The Journal of the Acoustical Society of America · doi:10.1121/1.5100272 · Cited by 71 · see citing works
Yang, H. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081041 · Cited by 70 · see citing works
Machine Learning Methods with Decision Forests for Parkinson’s Detection
Pramanik, M., Pradhan, R., Nandy, P., Bhoi, A. K., & Barsocchi, P. (2021) · Applied Sciences · doi:10.3390/app11020581 · Cited by 61 · see citing works
Škorvánek, M., Feketeová, E., Kurtis, M. M., Rusz, J., & Šonka, K. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00376 · Cited by 59 · see citing works
Jeancolas, L., Mangone, G., Petrovska‐Delacrétaz, D., Benali, H., Benkelfat, B.-E., Arnulf, I., Corvol, J., Vidailhet, M., & Lehéricy, S. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.01.003 · Cited by 48 · see citing works
Parkinson’s disease diagnosis using deep learning: A bibliometric analysis and literature review
Abumalloh, R. A., Nilashi, M., Samad, S., Ahmadi, H., Alghamdi, A., Alrizq, M., & AlYami, S. S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102285 · Cited by 48 · see citing works
Advances in the Research of Risk Factors and Prodromal Biomarkers of Parkinson’s Disease
Xie, F., Gao, X., Yang, W., Chang, Z., Yang, X., Wei, X., Huang, Z., Xie, H., Yue, Z., Zhou, F., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00520 · Cited by 47 · see citing works
Stefani, A., Antelmi, E., Arnaldi, D., Arnulf, I., During, E., Högl, B., Hu, M. M. T., Iranzo, Á., Luke, R., Peever, J. H., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00809-0 · Cited by 47 · see citing works
Hlavnička, J., Čmejla, R., Klempíř, J., Růžička, E., & Rusz, J. (2019) · IEEE Access · doi:10.1109/access.2019.2945874 · Cited by 47 · see citing works
Jeancolas, L., Benali, H., Benkelfat, B.-E., Mangone, G., Corvol, J., Vidailhet, M., Lehéricy, S., & Petrovska‐Delacrétaz, D. (2017) · International Conference on Advanced Technologies for Signal and Image Processing · doi:10.1109/atsip.2017.8075567 · Cited by 46 · see citing works
Rahman, A., Rizvi, S. S., Khan, A., Abbasi, A. A., Khan, S. U., & Chung, T. (2021) · Mobile Information Systems · doi:10.1155/2021/8822069 · Cited by 46 · see citing works
A Hybrid U-Lossian Deep Learning Network for Screening and Evaluating Parkinson’s Disease
Maskeliūnas, R., Damaševičius, R., Kulikajevas, A., Padervinskis, E., Pribuišis, K., & Uloza, V. (2022) · Applied Sciences · doi:10.3390/app122211601 · Cited by 40 · see citing works
Illner, V., Sovka, P., & Rusz, J. (2020) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2019.101831 · Cited by 38 · see citing works
Detecting Effect of Levodopa in Parkinson’s Disease Patients Using Sustained Phonemes
Pah, N. D., Motin, M. A., Kempster, P. A., & Kumar, D. K. (2021) · IEEE Journal of Translational Engineering in Health and Medicine · doi:10.1109/jtehm.2021.3066800 · Cited by 36 · see citing works
Novotný, M., Dušek, P., Daly, I., Růžička, E., & Rusz, J. (2019) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2019.101818 · Cited by 35 · see citing works
Khaskhoussy, R., & BenAyed, Y. (2022) · Social Network Analysis and Mining · doi:10.1007/s13278-022-00905-9 · Cited by 35 · see citing works
Arora, S., Lo, C., Hu, M., & Tsanas, A. (2021) · IEEE Access · doi:10.1109/access.2021.3057715 · Cited by 33 · see citing works
Voice quality severity and responsiveness to levodopa in Parkinson’s disease
Cushnie-Sparrow, D., Adams, S. G., Abeyesekera, A., Pieterman, M., Gilmore, G., & Jog, M. (2018) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2018.07.003 · Cited by 32 · see citing works
Prodromal PD: A new nosological entity
Schaeffer, E., Postuma, R. B., & Berg, D. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.01.003 · Cited by 33 · see citing works
Detecting Effect of Levodopa in Parkinson’s Disease Patients Using Sustained Phonemes
Pah, N. D., Motin, M. A., Kempster, P. A., & Kumar, D. (2021) · Figshare · Cited by 31 · see citing works
Parkinson’s Disease Detection Using Smartphone Recorded Phonemes in Real World Conditions
Motin, M. A., Pah, N. D., Raghav, S., & Kumar, D. (2022) · IEEE Access · doi:10.1109/access.2022.3203973 · Cited by 29 · see citing works
Skibińska, J., & Hošek, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21175 · Cited by 28 · see citing works
Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson’s Disease
Arora, S., Visanji, N. P., Mestre, T., Tsanas, A., AlDakheel, A., Connolly, B. S., Gasca‐Salas, C., Kern, D. S., Jain, J., Slow, E., et al. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-181389 · Cited by 28 · see citing works
Effect of Ageing on Acoustic Characteristics of Voice Pitch and Formants in Czech Vowels
Tykalová, T., Skrabal, D., Bořil, T., Čmejla, R., Volín, J., & Rusz, J. (2020) · Journal of Voice · doi:10.1016/j.jvoice.2020.02.022 · Cited by 25 · see citing works
Prospective memory impairment in idiopathic REM sleep behavior disorder
Bezdíček, O., Nikolai, T., Nepožitek, J., Peřinová, P., Kemlink, D., Dušek, P., Příhodová, I., Dostálová, S., Ibarburu, V., Trnka, J., et al. (2017) · The Clinical Neuropsychologist · doi:10.1080/13854046.2017.1394493 · Cited by 24 · see citing works
Friedová, L., Rusz, J., Motýl, J., Srpová, B., Vodehnalová, K., Andělová, M., Novotná, K., Novotný, M., Růžičková, H., Tykalová, T., et al. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.04.018 · Cited by 23 · see citing works
Evaluating the Performance of wav2vec Embedding for Parkinson's Disease Detection
Klempíř, O., Příhoda, D., & Krupička, R. (2023) · Measurement Science Review · doi:10.2478/msr-2023-0033 · Cited by 18 · see citing works
The Motor Dysfunction Seen in Isolated REM Sleep Behavior Disorder
Simonet, C., Pérez‐Carbonell, L., Galmés-Ordinas, M. À., Huxford, B., Chohan, H., Gill, A., Leschziner, G. D., Lees, A. J., Schrag, A. E., & Noyce, A. J. (2024) · Movement Disorders · doi:10.1002/mds.29779 · Cited by 17 · see citing works
Suphinnapong, P., Phokaewvarangkul, O., Thubthong, N., Teeramongkonrasmee, A., Mahattanasakul, P., Lorwatanapongsa, P., & Bhidayasiri, R. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117487 · Cited by 17 · see citing works
Voice changes in prodromal Parkinson's disease: Is a new biomarker within earshot?
Postuma, R. B. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.08.019 · Cited by 17 · see citing works
Random Forest Algorithm Based on Speech for Early Identification of Parkinson’s Disease
Fan, P. (2022) · Computational Intelligence and Neuroscience · doi:10.1155/2022/3287068 · Cited by 15 · see citing works
RetractedSchalling, E., Winkler, H., & Franzén, E. (2021) · Brain and Behavior · doi:10.1002/brb3.2150 · Cited by 15 · see citing works
Summers, R. L. S., Rafferty, M. R., Howell, M. J., & MacKinnon, C. D. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211011238 · Cited by 13 · see citing works
The ForEx++ based decision tree ensemble approach for robust detection of Parkinson’s disease
Pramanik, M., Pradhan, R., Nandy, P., Bhoi, A. K., & Barsocchi, P. (2022) · Journal of Ambient Intelligence and Humanized Computing · doi:10.1007/s12652-022-03719-x · Cited by 12 · see citing works
Benba, A., Jilbab, A., Sandabad, S., & Hammouch, A. (2019) · International Journal of Speech Technology · doi:10.1007/s10772-018-09588-0 · Cited by 12 · see citing works
Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease?
Dall’Antonia, I., Šonka, K., & Dušek, P. (2018) · Prague Medical Report · doi:10.14712/23362936.2018.8 · Cited by 11 · see citing works
Deep Clinical Phenotyping of Parkinson’s Disease: Towards a New Era of Research and Clinical Care
Xu, Z., Shen, B., Tang, Y., Wu, J., & Wang, J. (2022) · Phenomics · doi:10.1007/s43657-022-00051-4 · Cited by 11 · see citing works
Compensatory articulatory mechanisms preserve intelligibility in prodromal Parkinson's disease
Thies, T., Mücke, D., Geerts, N., Seger, A., Fink, G. R., Barbe, M. T., & Sommerauer, M. (2023) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2023.105487 · Cited by 10 · see citing works
Vandana, V. P., Darshini, J. K., Vikram, V. H., Kamble, N. L., Pal, P. K., & Ravi, Y. (2021) · Journal of Neurosciences in Rural Practice · doi:10.1055/s-0041-1735249 · Cited by 9 · see citing works
Castelli, M., Sousa, M., Illner, V., Single, M., Amstutz, D., Maradan‐Gachet, M. E., Magalhães, A. D., Debove, I., Rusz, J., Martínez‐Martín, P., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-00939-8 · Cited by 8 · see citing works
Isolated REM Sleep Behaviour Disorder—Is Screening Possible?
Cesari, M., Brink-Kjær, A., During, E., Ganglberger, W., Gnarra, O., Huang, B., Sommerauer, M., Ratti, P., Rechichi, I., Wing, Y. K., et al. (2025) · Journal of Sleep Research · doi:10.1111/jsr.70109 · Cited by 8 · see citing works
Vowel Articulation Dynamic Stability Related to Parkinson’s Disease Rating Features: Male Dataset
Gómez‐Vilda, P., Galáž, Z., Mekyska, J., Vicente, J. M. F., Gómez-Rodellar, A., Alonso, D. P., Smékal, Z., Eliasova, I., Košťálová, M., & Rektorová, I. (2018) · International Journal of Neural Systems · doi:10.1142/s0129065718500375 · Cited by 8 · see citing works
Nilashi, M., Abumalloh, R. A., Ahmadi, H., Samad, S., AlYami, S. S., Alghamdi, A., Alrizq, M., & Yusuf, S. Y. M. (2024) · International Journal of Fuzzy Systems · doi:10.1007/s40815-023-01665-0 · Cited by 8 · see citing works
Voice Analysis for Diagnosis and Monitoring Parkinson’s Disease
Pah, N. D., Motin, M. A., & Kumar, D. (2021) · Series in bioengineering · doi:10.1007/978-981-16-3056-9_8 · Cited by 8 · see citing works
Actigraphic Screening for Rapid Eye Movement Sleep Behavior DisorderPreprint
Kristián, Š., Dostálová, S., Nepožitek, J., y Losada, V. I. L., Dušek, P., Růžička, E., Šonka, K., & Kemlink, D. (2019) · medRxiv · doi:10.1101/19001867 · Cited by 8 · see citing works
Editorial: Prodromal Parkinson's Disease
Crosiers, D., Santens, P., & Chaudhuri, К. R. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.634490 · Cited by 8 · see citing works
Ma, A., Lau, K. K., & Thyagarajan, D. E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258786 · Cited by 7 · see citing works
Nisser, J., Derlien, S., Bublak, P., Schwab, M. G., Witte, O. W., Kesper, K., Schultze, T., & Rupprecht, S. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13459 · Cited by 7 · see citing works
Biomarkers for Detection of Parkinson’s Disease Using Machine Learning—A Short Review
Pramanik, M., Pradhan, R., & Nandy, P. (2020) · Advances in intelligent systems and computing · doi:10.1007/978-981-15-7394-1_43 · Cited by 7 · see citing works
In Silico Decoding of Parkinson’s: Speech & Writing Analysis
Ileșan, R. R., Ştefănigă, S.-A., Fleșar, R., Beyer, M., Ginghină, E., Peștean, A. S., Hirsch, M. C., Perju‐Dumbravă, L., & Faragó, P. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185573 · Cited by 5 · see citing works
Zhou, L., Zhu, L., & Liu, J. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00388 · Cited by 5 · see citing works
Speech Differences between Multiple System Atrophy and Parkinson's Disease
Hähnel, T., Nemitz, A., Schön, K., Berger, L., Vogel, A., Gruber, D., Schnalke, N., Bräuer, S., Falkenburger, B. H., & Gandor, F. (2025) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.70094 · Cited by 4 · see citing works
Diagnosis of REM Sleep Behavior Disorder
Stefani, A., Frauscher, B., & Högl, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-90152-7_18 · Cited by 4 · see citing works
Disruptions of frontostriatal language functions in Parkinson's disease
García, A. M., Bocanegra, Y., Birba, A., Orozco-Arroyave, J. R., Sedeño, L., & Ibáñez, A. (2020) · Genetics, Neurology, Behavior, and Diet in Parkinson's Disease · doi:10.1016/b978-0-12-815950-7.00026-6 · Cited by 2 · see citing works
Cross-Corpus Disparity of Parkinson's Voice Datasets Observed on Control Group Distribution
Pah, N. D., Indrawati, V., & Kumar, D. (2023) · International Conference on Artificial Intelligence in Information and Communication (ICAIIC) · doi:10.1109/icaiic57133.2023.10066982 · Cited by 2 · see citing works
Xu, Z., Li, L., Liu, X., Liang, X., Yang, M., Chen, Y., Han, X., Wang, J., Tang, Y., Zhang, M., et al. (2025) · Journal of Voice · doi:10.1016/j.jvoice.2025.05.024 · Cited by 2 · see citing works
RBD: Future Directions in Research and Clinical Care and Counseling
Högl, B., Videnović, A., Schenck, C. H., Heidbreder, A., & Santamaría, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-90152-7_45 · Cited by 2 · see citing works
Abstracts of the 8th International Conference on Speech Motor Control Groningen, August 2022
Sstp, R. (2022) · Stem- Spraak- en Taalpathologie · doi:10.21827/32.8310/2022-115 · Cited by 2 · see citing works
Raheel, K., Sheybani, L., Biabani, N., See, Q. R., Delogu, A., Rosenzweig, J., Cvetković, Z., Leech, R., Grossman, N., Tahmasian, M., et al. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102298 · Cited by 1 · see citing works
Brink-Kjær, A., Rechichi, I., Arnaldi, D., Cesarone, O., During, E., Feuerstein, S., Gunter, K. M., Högl, B., Ibrahim, A., Jennum, P., et al. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102299 · Cited by 1 · see citing works
Parkinson’s Disease in Humans and in Nonhuman Primate Aging and Neurotoxin Models
Metzger, J. M., Jones, C. A., & Emborg, M. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00046-4 · Cited by 1 · see citing works
Biomarkers of Neurodegenerative Disease in Idiopathic RBD
Postuma, R. B. (2018) · Springer eBooks · doi:10.1007/978-3-319-90152-7_36 · Cited by 1 · see citing works
Diagnostic Study of Acoustic Features in Parkinson’s Disease Based on Lasso-Logistic Regression
张, 集. (2024) · Statistics and Applications · doi:10.12677/sa.2024.132025 · Cited by 1 · see citing works
[Diagnostic Value of Speech Acoustic Analysis in Parkinson's Disease].
Xu, Z., Zhang, M., & Wang, J. (2022) · PubMed Central · doi:10.12182/20220760304
Compensatory mechanisms enables intelligibility in prodromal Parkinson’s diseasePreprint
Thies, T., Mücke, D., Geerts, N., Seger, A., Fink, G. R., Barbe, M. T., & Sommerauer, M. (2022) · medRxiv · doi:10.1101/2022.12.14.22283451
Clinical Study of Voice Parameters in Early Parkinson’s Disease and Atypical Parkinsonism
刁, 久. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.134875
The motor anomalies seen in isolated REM sleep behavior disorderPreprint
Simonet, C., Pérez‐Carbonell, L., Huxford, B., Chohan, H., Gill, A., Leschziner, G. D., Lees, A. J., Schrag, A. E., & Noyce, A. J. (2023) · medRxiv · doi:10.1101/2023.06.11.23291091
Sanhueza-Garrido, M., Rojas, C., & García-Flores, V. (2023) · Revista CEFAC · doi:10.1590/1982-0216/20232564723s
Sanhueza-Garrido, M., Rojas, C., & García-Flores, V. (2023) · Revista CEFAC · doi:10.1590/1982-0216/20232564723
Gaur, N., & Jain, R. (2023) · Lecture notes in networks and systems · doi:10.1007/978-981-99-6568-7_51
Analyzing changes in parkinsonian speech over time: a diachronic experimental phonetics study
Pettorino, M., & Maffia, M. M. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1334198
Clinical and cognitive assessment in Friedreich ataxia clinical trials: a review
Darriba, Á., Münnich, A., Cardoso-Leite, P., Funalot, B., & Waszak, F. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1558493
K, K. D. S., Sitharth, S., Vishnu, K. S., Devisri, Y., & Sanjana, S. (2025) · International Conference on Emerging Technologies in Computing and Communication (ETCC) · doi:10.1109/etcc65847.2025.11108591
Classification of Parkinson’s Disease Using Machine Learning Techniques
Dekka, S., Raju, K. N., Sai, D. M., Pallavi, M. S., & Sambana, B. (2025) · Springer proceedings in mathematics & statistics · doi:10.1007/978-3-031-51342-8_3
Rapid Eye Movement Sleep Behavior Disorder: An Insight into the Prodromal Parkinson’s Disease Speech
Novotný, M., & Rusz, J. (2025) · Communications in computer and information science · doi:10.1007/978-3-032-07083-8_6
Dysarthria assessment in multiple sclerosis patients
Ranucci, D., Falco, F., Nicolella, V., Marra, L. A., Caracciolo, F., Migliaccio, L., Corsini, G., Esposito, A., Castiello, A., Petracca, M., et al. (2025) · Multiple Sclerosis Journal · doi:10.1177/13524585251400108
Gianlorenço, A. C., Teixeira, P. E. P., Costa, V., Fabris-Moraes, W., Gonzalez‐Mego, P., Ramos-Estébanez, C., Stadio, A. D., Camsari, D. D., El-Hagrassy, M. M., Fregni, F., et al. (2025) · Brain Sciences · doi:10.3390/brainsci16010048
Villoria, R. H. (2026) · Springer eBooks · doi:10.1007/978-3-032-03134-1_4
Pagano, M. C., Corallo, F., Anselmo, A., Cardile, D., Luca, R. D., Quartarone, A., Calabrò, R. S., & Cappadona, I. (2026) · Brain Sciences · doi:10.3390/brainsci16020216
Voice, Speech, and Large Language Models in Neurology: From Acoustic Biomarkers to Conversational AI
Shelly, S. (2026) · Computation · doi:10.3390/computation14070160
- Authors
- Rusz, J., Hlavnička, J., Tykalová, T., Bušková, J., Ulmanová, O., Růžička, E., & Šonka, K.
- Affiliations
- Charles University (CZ)
- Czech Technical University in Prague (CZ)
- Corresponding author
- Rusz, Jan
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 19
- Pages
- 141-147
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W1431429584
- Cited by
- 94
- References
- 34
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 16 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 6 · 2015: 1
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health of the Czech Republic (MZ ČR 15-28038A)
- Topics
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- rapid eye movement sleep behavior disorder, speech disorders, speech acoustics, prodromal Parkinson's disease, disfluency, aperiodicity
- MeSH terms
- Aged, Articulation Disorders, Female, Humans, Male, Middle Aged, Parkinson Disease, Severity of Illness Index, REM Sleep Behavior Disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
