Cited by 326Voice and Speech DisordersParkinson's Disease Mechanisms and TreatmentsPhonetics and Phonology Research

Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder

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Hlavnička, Jan, Čmejla, Roman, Tykalová, Tereza, Šonka, Karel, Růžička, Evžen, Rusz, Jan·2017·Scientific Reports

Abstract

For generations, the evaluation of speech abnormalities in neurodegenerative disorders such as Parkinson’s disease (PD) has been limited to perceptual tests or user-controlled laboratory analysis based upon rather small samples of human vocalizations. Our study introduces a fully automated method that yields significant features related to respiratory deficits, dysphonia, imprecise articulation and dysrhythmia from acoustic microphone data of natural connected speech for predicting early and distinctive patterns of neurodegeneration. We compared speech recordings of 50 subjects with rapid eye movement sleep behaviour disorder (RBD), 30 newly diagnosed, untreated PD patients and 50 healthy controls, and showed that subliminal parkinsonian speech deficits can be reliably captured even in RBD patients, which are at high risk of developing PD or other synucleinopathies. Thus, automated vocal analysis should soon be able to contribute to screening and diagnostic procedures for prodromal parkinsonian neurodegeneration in natural environments.

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  1. [5]Duffy, J. R. Motor Speech Disorders: Substrates, Differential Diagnosis and Management, 3rd ed., Mosby, St. Louis (2013).
  2. [24]Weismer, G. & McNeil, M. Articulatory characteristics of Parkinsonian dysarthria: Segmental and phrase-level timing, spirantization, and glottal-supraglottal coordination. The dysarthrias: Physiology, acoustics, perception, management, College-Hill Press, San Diego 101–130 (1984).
  3. [38]American Academy of Sleep Medicine. International Classification of Sleep Disorders, Third Edition: Diagnostic and Coding Manual, Westchester, Illinois: American Academy of Sleep Medicine (2014).

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Authors
Hlavnička, J., Čmejla, R., Tykalová, T., Šonka, K., Růžička, E., & Rusz, J.
Affiliations
  • Czech Technical University in Prague (CZ)
  • Charles University (CZ)
Corresponding author
Rusz, Jan
Venue
Scientific Reports
Published
2017-02-02
Volume
7
Issue
1
Pages
12-12
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2580210409
Cited by
326
References
37
Citations by year
2026: 11 · 2025: 25 · 2024: 25 · 2023: 30 · 2022: 28 · 2021: 71 · 2020: 44 · 2019: 46 · 2018: 33 · 2017: 11 · 2013: 1
FWCI
27.12
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Cvut DSpace (Czech Technical University) (submittedVersion, cc-by)
Funders
  • Grantová Agentura České Republiky (GA16-07879S)
  • Ministerstvo Zdravotnictví Ceské Republiky (16-28914A, 15 – 28038A)
Topics
  • Health Sciences › Medicine › Physiology › Voice and Speech Disorders
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
Keywords
Parkinson's disease, rapid eye movement sleep behavior disorder, automated speech analysis, acoustic biomarkers, early diagnosis, prodromal neurodegeneration, dysphonia, cardiac arrhythmias, synucleinopathies, speech screening
MeSH terms
Adult, Aged, Aged, 80 and over, Articulation Disorders, Female, Humans, Male, Middle Aged, Parkinson Disease, Pattern Recognition, Automated, Respiration, Biomarkers, REM Sleep Behavior Disorder, Dysphonia

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