Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder
Open accessAbstract
For generations, the evaluation of speech abnormalities in neurodegenerative disorders such as Parkinson’s disease (PD) has been limited to perceptual tests or user-controlled laboratory analysis based upon rather small samples of human vocalizations. Our study introduces a fully automated method that yields significant features related to respiratory deficits, dysphonia, imprecise articulation and dysrhythmia from acoustic microphone data of natural connected speech for predicting early and distinctive patterns of neurodegeneration. We compared speech recordings of 50 subjects with rapid eye movement sleep behaviour disorder (RBD), 30 newly diagnosed, untreated PD patients and 50 healthy controls, and showed that subliminal parkinsonian speech deficits can be reliably captured even in RBD patients, which are at high risk of developing PD or other synucleinopathies. Thus, automated vocal analysis should soon be able to contribute to screening and diagnostic procedures for prodromal parkinsonian neurodegeneration in natural environments.
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MFCC2 reflects the ratio between vocal tract resonation of the high, and vocal fold vibration of the low, Mel-frequency bands; a parameter not specifically scored by MDS-UPDRS item 2.1.
“MFCC2 reflects the ratio between vocal tract resonation of the high, and vocal fold vibration of the low, Mel‐frequency bands67; a parameter not specifically scored by MDS‐UPDRS item 2.1.25”
From Evaluation of smartphone‐based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial (2018) · cites this paper as [67]
Some of these linguistic deficits may occur preclinically in each of these neurodegenerative disorders.
“Some of these deficits may actually occur preclini cally in each of these disorders. 3,33-36”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [35]
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- Authors
- Hlavnička, J., Čmejla, R., Tykalová, T., Šonka, K., Růžička, E., & Rusz, J.
- Affiliations
- Czech Technical University in Prague (CZ)
- Charles University (CZ)
- Corresponding author
- Rusz, Jan
- Venue
- Scientific Reports
- Published
- 2017-02-02
- Volume
- 7
- Issue
- 1
- Pages
- 12-12
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5428345
- OpenAlex
- W2580210409
- Cited by
- 326
- References
- 37
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 25 · 2023: 30 · 2022: 28 · 2021: 71 · 2020: 44 · 2019: 46 · 2018: 33 · 2017: 11 · 2013: 1
- FWCI
- 27.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Cvut DSpace (Czech Technical University) (submittedVersion, cc-by)
- Funders
- Grantová Agentura České Republiky (GA16-07879S)
- Ministerstvo Zdravotnictví Ceské Republiky (16-28914A, 15 – 28038A)
- Topics
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
- Keywords
- Parkinson's disease, rapid eye movement sleep behavior disorder, automated speech analysis, acoustic biomarkers, early diagnosis, prodromal neurodegeneration, dysphonia, cardiac arrhythmias, synucleinopathies, speech screening
- MeSH terms
- Adult, Aged, Aged, 80 and over, Articulation Disorders, Female, Humans, Male, Middle Aged, Parkinson Disease, Pattern Recognition, Automated, Respiration, Biomarkers, REM Sleep Behavior Disorder, Dysphonia
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