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Cited by 61Parkinson's Disease Mechanisms and TreatmentsSleep and related disordersDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Sleep problems affect quality of life in Parkinson's disease along disease progression

Liguori, Claudio, De Franco, Valentino, Cerroni, Rocco, Spanetta, Matteo, Mercuri, Nicola Biagio, Stefani, Alessandro, Pierantozzi, Mariangela, Di Pucchio, Alessandra·2021·Sleep Medicine
DOI 10.1016/j.sleep.2021.02.036
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Abstract

OBJECTIVES Non-motor symptoms (NMS) frequently impact health-related quality of life (HRQoL) in patients with Parkinson's Disease (PD). Sleep problems represent one of the main NMS complained by PD patients. In this observation study, sleep problems measured by Parkinson's Disease Sleep Scale - 2nd version (PDSS-2), and HRQoL measured by Parkinson's Disease Questionnaire-39 (PDQ39) were quantified in patients with PD ranging from mild to moderate-advanced disease stages, and correlated to motor impairment and anti-PD therapy. METHODS We included idiopathic PD patients who underwent PDSS-2 and PDQ39. Moreover, we assessed patients' motor symptoms by rating the Unified Parkinson's Disease Rating Scale (UPDRS) - III section (motor examination), patients' PD status following H&Y stage, and levodopa equivalent daily dose (LEDD). RESULTS One-hundred and fifty-four patients with PD were included and distributed for H&Y stage. PDSS-2 and PDQ39 total and sub-items scores significantly increased with the H&Y stage. PDSS-2 total score significantly correlated with PDQ39 total score (γ = 0.63, P < 0.01). Finally, distributing PD patients according to the PDSS-2 cut-off for detecting sleep disturbances, we found in poor sleepers (n = 58) higher PDQ39 scores than good sleepers (n = 89). CONCLUSIONS Sleep problems are very common in patients with PD and severely impact on HRQoL. Sleep impairment and low HRQoL occur from the early stages of the disease and deteriorate along disease progression. Further studies investigating sleep and quality of life should be planned for targeting sleep improvement to increase HRQoL and possibly reduce motor impairment.

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Crossref · 10.1016/j.sleep.2021.02.036

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Metadata

Authors
Liguori, C., De Franco, V., Cerroni, R., Spanetta, M., Mercuri, N. B., Stefani, A., Pierantozzi, M., & Di Pucchio, A.
Affiliations
University of Rome Tor Vergata (IT)
Corresponding author
Liguori, Claudio
ORCID
Venue
Sleep Medicine
Publisher
Elsevier BV
Published
2021-05
Volume
81
Pages
307-311
ISSN
1389-9457 (ISSN-L)
DOI
10.1016/j.sleep.2021.02.036
OpenAlex
W3131429994
Semantic Scholar
d2d8c45aa10237ee659496ec1328bc9f6675a988
Cited by
61
References
24
Citations by year
2026: 11 · 2025: 16 · 2024: 17 · 2023: 10 · 2022: 4 · 2021: 3
FWCI
4.51
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Sleep Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Funders
AbbVie
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Parkinson's disease, sleep disorders, health-related quality of life, non-motor symptoms, disease progression, Parkinson's Disease Sleep Scale, Parkinson's Disease Questionnaire, motor impairment, levodopa equivalent daily dose
MeSH terms
Humans, Parkinson Disease, Quality of Life, Surveys and Questionnaires, Sleep Wake Disorders, Disease Progression

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.