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Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses

Orth, Gérard·2006·Seminars in Immunology

Abstract

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma. EV results from an abnormal susceptibility to infection by specific human papillomavirus (HPV) genotypes (beta-papillomaviruses) which include the potentially oncogenic HPV5. EV-specific HPVs are considered as harmless for the general population. EV was recently found to be caused by invalidating mutations in two adjacent, related, novel genes, EVER1/TMC6 and EVER2/TMC8. EVER genes encode transmembrane proteins located in the endoplasmic reticulum, which are likely to function as modifiers of ion transporters or channels and to be involved in signal transduction. It was proposed that EV was a primary defect of innate immunity. Our hypothesis is that EVER proteins act as restriction factors for EV-specific HPVs in keratinocytes, and that EV represents a primary deficiency of intrinsic immunity against certain papillomaviruses.

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Metadata

Authors
Orth, G.
Venue
Seminars in Immunology
Publisher
Elsevier BV
Published
2006-12
Volume
18
Issue
6
Pages
362-374
ISSN
1044-5323
Cited by
249
References
4
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses. https://app.cochat.ai/papers/10.1016/j.smim.2006.07.008
The paper
Orth, G. (2006). Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses. Seminars in Immunology. https://doi.org/10.1016/j.smim.2006.07.008