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Cited by 308

The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.

Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment

Open access
Whiteside, Theresa L.·2018·Seminars in Immunology
DOI 10.1016/j.smim.2017.12.003
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Abstract

Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co-opt MSCs and re-program their functional profile from normally trophic to pro-tumorigenic. These tumor-derived small vesicles called “TEX” carry and deliver a cargo rich in proteins and nucleic acids to MSCs. Upon interactions with surface receptors on MSCs and uptake of the exosome cargo by MSCs, molecular, transcriptional and translational changes occur that convert MSCs into producers of factors that are necessary for tumor growth and that also alter functions of non-tumor cells in the TME. The MSCs re-programmed by TEX become avid producers of their own exosomes that carry and deliver mRNA and miRNA species as well as molecular signals not only back to tumor cells, directly enhancing their growth, but also horizontally to fibroblasts, endothelial cells and immune cells in the TME, indirectly enhancing their pro-tumor functions. TEX-driven cross-talk of MSCs with immune cells blocks their anti-tumor activity and/or converts them into suppressor cells. MSCs re-programmed by TEX mediate pro-angiogenic activity and convert stromal cells into cancer-associated fibroblasts (CAFs). Although MSCs have a potential to exert anti-tumor activities, they largely provide service to the tumor using the multidirectional communication system established by exosomes in the TME. Future therapeutic options consider disruption of this complex vicious cycle by either molecular or gene-regulated silencing of pro-tumor effects mediated by MSCs in the TME.

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Metadata

Authors
Whiteside, T. L.
Venue
Seminars in Immunology
Publisher
Elsevier BV
Published
2018-02
Volume
35
Pages
69-79
ISSN
1044-5323 (ISSN-L)
DOI
10.1016/j.smim.2017.12.003
OpenAlex
W2776806294
Cited by
308
References
119
FWCI
8.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. https://app.cochat.ai/papers/10.1016/j.smim.2017.12.003
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Whiteside, T. L. (2018). Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. Seminars in Immunology. https://doi.org/10.1016/j.smim.2017.12.003

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.