The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Noradrenergic modulation of wakefulness/arousal
Open accessAbstract
The locus coeruleus-noradrenergic systems supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of locus coeruleus noradrenergic neurons has long-suggested a role of this system in the induction of an alert waking state. Work over the past two decades provides unambiguous evidence that the locus coeruleus, and likely other noradrenergic nuclei, exert potent wake-promoting actions via an activation of noradrenergic β- and α1-receptors located within multiple subcortical structures, including the general regions of the medial septal area, the medial preoptic area and, most recently, the lateral hypothalamus. Conversely, global blockade of β- and α1-receptors or suppression of norepinephrine release results in profound sedation. The wake-promoting action of central noradrenergic neurotransmission has clinical implications for treatment of sleep/arousal disorders, such as insomnia and narcolepsy, and clinical conditions associated with excessive arousal, such as post-traumatic stress disorder.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Self-citationAston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Sleep and arousal: thalamocortical mechanisms
McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857
Nelson, L. E., Lu, J., Guo, T., Saper, C. B., Franks, N. P., & Maze, M. (2003) · Anesthesiology · doi:10.1097/00000542-200302000-00024 · Cited by 854
Histamine in the regulation of wakefulness
Thakkar, M. M. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.06.004 · Cited by 251
Berridge, C. W., Isaac, S. O., & España, R. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.350 · Cited by 69
Self-citation
Cited by
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Locus coeruleus: a new look at the blue spot
Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., et al. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0360-9 · Cited by 720
Self-citationMather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695
Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications
Haack, M., Simpson, N., Sethna, N., Kaur, S., & Mullington, J. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0439-z · Cited by 641
A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine
Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.037 · Cited by 545
Metadata
- Authors
- Berridge, C. W., Schmeichel, B. E., & España, R. A.
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 16
- Issue
- 2
- Pages
- 187-197
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2076495702
- Cited by
- 346
- References
- 9
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Noradrenergic modulation of wakefulness/arousal. https://app.cochat.ai/papers/10.1016/j.smrv.2011.12.003
- The paper
- Berridge, C. W., Schmeichel, B. E., & España, R. A. (2012). Noradrenergic modulation of wakefulness/arousal. Sleep Medicine Reviews. https://doi.org/10.1016/j.smrv.2011.12.003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
