Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

Applied Nonparametric Statistics

Wozniak, P. J., & Daniel, W. W. (1991) · Technometrics · doi:10.2307/1268795 · Cited by 5,008 · see citing works

Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups

Hobson, J. A., McCarley, R. W., & Wyzinski, P. (1975) · Science · doi:10.1126/science.1094539 · Cited by 1,238 · see citing works

Raphe unit activity in freely moving cats: correlation with level of behavioral arousal.

Trulson, M., & Jacobs, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90157-4 · Cited by 815 · see citing works

II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

Redmond, D. E., & Huang, Y. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90087-0 · Cited by 662 · see citing works

The locus coeruleus: A cytoarchitectonic, golgi and immunohistochemical study in the albino rat

Swanson, L. W. (1976) · Brain Research · doi:10.1016/0006-8993(76)90207-9 · Cited by 518 · see citing works

The locus coeruleus: neurobiology of a central noradrenergic nucleus

Amaral, D. G., & Sinnamon, H. M. (1977) · Progress in Neurobiology · doi:10.1016/0301-0082(77)90016-8 · Cited by 495 · see citing works

Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex

Foote, S. L., Freedman, R., & Oliver, A. P. (1975) · Brain Research · doi:10.1016/0006-8993(75)90699-x · Cited by 458 · see citing works

Noradrenergic neurons: Morphine inhibition of spontaneous activity

Korf, J., Bunney, B. S., & Aghajanian, G. K. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90045-4 · Cited by 434 · see citing works

Neuronal activity during the sleep-waking cycle

Steriade, M., & Hobson, J. A. (1976) · Progress in Neurobiology · doi:10.1016/0301-0082(76)90013-7 · Cited by 386 · see citing works

Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism

Cedarbaum, J. M., & Aghajanian, G. K. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90398-3 · Cited by 382 · see citing works

The action of norepinephrine in the rat hippocampus. IV. The effects of locus coeruleus stimulation on evoked hippocampal unit activity

Segal, M., & Bloom, F. E. (1976) · Brain Research · doi:10.1016/0006-8993(76)90141-4 · Cited by 311 · see citing works

Theories of the dorsal bundle extinction effect

Mason, S. T., & Iversen, S. D. (1979) · Brain Research Reviews · doi:10.1016/0165-0173(79)90018-3 · Cited by 250 · see citing works

Interaction of norepinephrine with cerebellar activity evoked by mossy and climbing fibers

Freedman, R., Hoffer, B. J., Woodward, D. J., & Puro, D. G. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90175-3 · Cited by 230 · see citing works

Activity patterns of catecholamine‐containing pontine neurons in the dorso‐lateral tegmentum of unrestrained cats

Chu, N., & Bloom, F. E. (1974) · Journal of Neurobiology · doi:10.1002/neu.480050605 · Cited by 207 · see citing works

Effect of minor tranquillisers on hippocampal θ rhythm mimicked by depletion of forebrain noradrenaline

Gray, J. A., McNaughton, N., James, D. T. D., & Kelly, P. H. (1975) · Nature · doi:10.1038/258424a0 · Cited by 183 · see citing works

Fluorescence histochemistry of monoamine‐containing cell bodies in the brain stem of the squirrel monkey (Saimiri sciureus). IV. An atlas

Carlo, V. D., Hubbard, J. E., & Pate, P. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901520404 · Cited by 143 · see citing works

Catecholamine‐containing neurons of the nucleus locus coeruleus in the cat

Jones, B. E., & Moore, R. Y. (1974) · The Journal of comparative neurology · doi:10.1002/cne.901570105 · Cited by 136 · see citing works

A study of inputs to antidromically identified neurons of the locus coeruleus

Takigawa, M., & Mogenson, G. J. (1977) · Brain Research · doi:10.1016/0006-8993(77)91027-7 · Cited by 117 · see citing works

The locus coeruleus, catecholamines, and REM sleep: a critical review.

Ramm, P. (1979) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(79)90212-7 · Cited by 79 · see citing works

The Peripheral and Central Role of the Catecholamines in the Mechanisms of Anxiety

LADER, M. H. (2017) · International Pharmacopsychiatry · doi:10.1159/000468126 · Cited by 69 · see citing works

The locus coeruleus in behavior regulation: evidence for behavior-specific versus general involvement

Clark, T. K. (1979) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(79)90393-5 · Cited by 49 · see citing works

Responses of primate locus coeruleus and subcoeruleus neurons to stimulation at reinforcing brain sites and to natural reinforcers

German, D. C., & Fetz, E. E. (1976) · Brain Research · doi:10.1016/0006-8993(76)90030-5 · Cited by 40 · see citing works

Predictive reward signal of dopamine neurons

Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works

An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance

Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472 · see citing works

Getting formal with dopamine and reward

Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works

Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle

Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960 · see citing works

Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory

Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960 · see citing works

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901 · see citing works

Decision making, the P3, and the locus coeruleus–norepinephrine system

Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.510 · Cited by 1,678 · see citing works

Neuronal Coding of Prediction Errors

Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427 · see citing works

The cognitive neuroscience of sustained attention: where top-down meets bottom-up.

Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194 · see citing works

Selective neuronal vulnerability in Parkinson disease

Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,120 · see citing works

Tuning arousal with optogenetic modulation of locus coeruleus neurons

Carter, M. E., Yizhar, O., Chikahisa, S., Nguyen, H., Adamantidis, A., Nishino, S., Deisseroth, K., & de Lecea, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2682 · Cited by 993 · see citing works

Orienting and reorienting: the locus coeruleus mediates cognition through arousal

Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056 · see citing works

Clinical and Biochemical Manifestations of Depression

Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057 · see citing works

Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity

Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948 · see citing works

Role of locus coeruleus in attention and behavioral flexibility

Aston-Jones, G., Rajkowski, J., & Cohen, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00140-7 · Cited by 900 · see citing works

Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis.

Johnson, E. O., Kamilaris, T., Chrousos, G., & Gold, P. (1992) · Neuroscience and Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80175-7 · Cited by 900 · see citing works

Network reset: a simplified overarching theory of locus coeruleus noradrenaline function

Bouret, S., & Sara, S. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.09.002 · Cited by 806 · see citing works

Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus function

Gilzenrat, M. S., Nieuwenhuis, S., Jepma, M., & Cohen, J. D. (2010) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.10.2.252 · Cited by 798 · see citing works

The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network

Aston‐Jones, G., Ennis, M. J., Pieribone, V. A., Nickell, W. T., & Shipley, M. T. (1986) · Science · doi:10.1126/science.3775363 · Cited by 778 · see citing works

Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation

Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777229 · Cited by 766 · see citing works

Sex differences in stress-related psychiatric disorders: neurobiological perspectives

Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737 · see citing works

The role of locus coeruleus in the regulation of cognitive performance

Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715 · see citing works

Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory

Mather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695 · see citing works

CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

McCall, J. G., Al-Hasani, R., Siuda, E. R., Hong, D. Y., Norris, A. J., Ford, C. P., & Bruchas, M. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.002 · Cited by 666 · see citing works

Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task

Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04467.1994 · Cited by 637 · see citing works

Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance

Aston‐Jones, G., & Cohen, J. D. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20723 · Cited by 630 · see citing works

Cellular mechanisms of brain state-dependent gain modulation in visual cortex

Polack, P.-O., Friedman, J., & Golshani, P. (2013) · Nature Neuroscience · doi:10.1038/nn.3464 · Cited by 628 · see citing works

Noradrenergic Function in Panic Anxiety: Effects of Yohimbine in Healthy Subjects and Patients With Agoraphobia and Panic Disorder

Charney, D. S. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790190025003 · Cited by 599 · see citing works

Noradrenergic mechanisms in stress and anxiety: I. preclinical studies

Bremner, J., Krystal, J., Southwick, S., & Charney, D. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199605)23:1 · Cited by 571 · see citing works

Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance

Aston‐Jones, G., Chiang, C., & Alexinsky, T. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63830-3 · Cited by 589 · see citing works

Adrenergic pharmacology and cognition: Focus on the prefrontal cortex

Ramos, B. P., & Arnsten, A. F. T. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.006 · Cited by 641 · see citing works

Effects of sleep and arousal on the processing of visual information in the cat

Livingstone, M. S., & Hubel, D. H. (1981) · Nature · doi:10.1038/291554a0 · Cited by 583 · see citing works

Organization of the Locus Coeruleus-Norepinephrine System

Schwarz, L. A., & Luo, L. (2015) · Current Biology · doi:10.1016/j.cub.2015.09.039 · Cited by 578 · see citing works

Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder

Southwick, S. M., Bremner, J. D., Rasmusson, A., Morgan, C. A., Arnsten, A., & Charney, D. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00219-x · Cited by 573 · see citing works

Convergent regulation of locus coeruleus activity as an adaptive response to stress

Valentino, R. J., & Van Bockstaele, E. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.062 · Cited by 569 · see citing works

Pupillometry and P3 index the locus coeruleus-noradrenergic arousal function in humans

Murphy, P. R., Robertson, I. H., Balsters, J. H., & O'connell, R. G. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01226.x · Cited by 519 · see citing works

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

Paukert, M., Agarwal, A., Cha, J., Doze, V. A., Kang, J. U., & Bergles, D. E. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.038 · Cited by 556 · see citing works

Clinical and Biochemical Manifestations of Depression

Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808113190606 · Cited by 547 · see citing works

Brain mechanisms of insomnia: new perspectives on causes and consequences

Someren, E. J. W. V. (2020) · Physiological Reviews · doi:10.1152/physrev.00046.2019 · Cited by 558 · see citing works

Neurobiology of REM and NREM sleep

McCarley, R. W. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.005 · Cited by 538 · see citing works

Time-related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task

Paus, T., Zatorre, R. J., Hofle, N., Caramanos, Z., Gotman, J., Petrides, M., & Evans, A. C. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.3.392 · Cited by 514 · see citing works

The control of retinogeniculate transmission in the mammalian lateral geniculate nucleus

Sherman, S. M., & Christof Koch, A. (1986) · Experimental Brain Research · doi:10.1007/bf00235642 · Cited by 513 · see citing works

Neuropeptide S

Xu, Y.-L., Reinscheid, R. K., Huitrón‐Reséndiz, S., Clark, S. D., Wang, Z., Lin, S. H., Brücher, F., Zeng, J., Ly, N. K., Henriksen, S. J., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.005 · Cited by 510 · see citing works

Extrathalamic Modulation of Cortical Function

Foote, S. L., & Morrison, J. (1987) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.10.030187.000435 · Cited by 480 · see citing works

Neural mechanisms of selective visual attention.

Moore, T., & Zirnsak, M. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033400 · Cited by 471 · see citing works

Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex

Paus, T., Koski, L. M., Caramanos, Z., & Westbury, C. F. (1998) · Neuroreport · doi:10.1097/00001756-199806220-00001 · Cited by 462 · see citing works

Noradrenaline and Dopamine Neurons in the Reward/Effort Trade-Off: A Direct Electrophysiological Comparison in Behaving Monkeys

Varazzani, C., San‐Galli, A., Gilardeau, S., & Bouret, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0454-15.2015 · Cited by 446 · see citing works

Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans

Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777193 · Cited by 454 · see citing works

Efferent projections of nucleus locus coeruleus: Morphologic subpopulations have different efferent targets

Loughlin, S. E., Foote, S. L., & Grzanna, R. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90156-9 · Cited by 437 · see citing works

Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus

Berridge, C. W., & Foote, S. L. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03135.1991 · Cited by 434 · see citing works

α 2 -Adrenoceptor-Mediated Hyperpolarization of Locus Coeruleus Neurons: Intracellular Studies in Vivo

Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Science · doi:10.1126/science.6278591 · Cited by 431 · see citing works

Neurobiology of addiction

Goodman, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 412 · see citing works

Locus coeruleus and regulation of behavioral flexibility and attention

(2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26013-5 · Cited by 400 · see citing works

Noradrenergic and serotoninergic innervation of cortical, thalamic, and tectal visual structures in old and new world monkeys

Morrison, J. H., & Foote, S. L. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430110 · Cited by 392 · see citing works

Brainstem projections to spinal motoneurons: An update

Holstege, J. C., & Kuypers, H. G. J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90160-6 · Cited by 389 · see citing works

Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders

Arnsten, A. F. T., & Pliszka, S. R. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.020 · Cited by 383 · see citing works

Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli

Abercrombie, E., & Jacobs, B. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02837.1987 · Cited by 377 · see citing works

The reticular-activating hypofrontality (RAH) model of acute exercise

Dietrich, A., & Audiffren, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.001 · Cited by 365 · see citing works

Locus coeruleus activity in monkey: Phasic and tonic changes are associated with altered vigilance

Rajkowski, J., Kubiak, P., & Aston‐Jones, G. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90175-9 · Cited by 359 · see citing works

Noradrenergic modulation of arousal

Berridge, C. W. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.013 · Cited by 368 · see citing works

Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness

Buchsbaum, M. S., Wu, J. C., DeLisi, L. E., Holcomb, H. H., KESSLER, R. M., Johnson, J., King, A. C., Hazlett, E., Langston, K. C., & Post, R. M. (1986) · Journal of Affective Disorders · doi:10.1016/0165-0327(86)90036-4 · Cited by 368 · see citing works

A new three-dimensional model for emotions and monoamine neurotransmitters

Lövheim, H. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.11.016 · Cited by 362 · see citing works

Neuromodulation of Attention

Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works

Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II. Effects upon sleep-waking states

Webster, H. H., & Jones, B. E. (1988) · Brain Research · doi:10.1016/0006-8993(88)90471-4 · Cited by 350 · see citing works

Noradrenergic modulation of wakefulness/arousal

Berridge, C. W., Schmeichel, B. E., & España, R. A. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.12.003 · Cited by 349 · see citing works

Overlapping distributions of orexin/hypocretin‐ and dopamine‐β‐hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress

Baldo, B. A., Daniel, R. A., Berridge, C. W., & Kelley, A. E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10783 · Cited by 346 · see citing works

Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey

Arnsten, A. F. T., & Goldman-Rakic, P. S. (1984) · Brain Research · doi:10.1016/0006-8993(84)90351-2 · Cited by 333 · see citing works

Recognition memory: neuronal substrates of the judgement of prior occurrence

Brown, M. W., & Xiang, J. ‐. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00002-1 · Cited by 329 · see citing works

Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology

Svensson, T. H. (1987) · Psychopharmacology · doi:10.1007/bf00215471 · Cited by 334 · see citing works

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

Weinshenker, D. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.01.010 · Cited by 323 · see citing works

Single unit activity of locus coeruleus neurons in the freely moving cat

Rasmussen, K., Morilak, D. A., & Jacobs, B. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)90370-7 · Cited by 324 · see citing works

Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons

Jodoj, E., Chiang, C., & Aston-Jones, G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00372-2 · Cited by 321 · see citing works

Evolving concepts of sleep cycle generation: From brain centers to neuronal populations

Hobson, J. A., Lydic, R., & Baghdoyan, H. A. (1986) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00046215 · Cited by 316 · see citing works

Clonidine Benefits Children with Attention Deficit Disorder and Hyperactivity: Report of a Double-Blind Placebo-Crossover Therapeutic Trial

Hunt, R. D., Minderaa, R. B., & Cohen, D. J. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60065-0 · Cited by 313 · see citing works

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

España, R. A., Baldo, B. A., Kelley, A. E., & Berridge, C. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00319-0 · Cited by 311 · see citing works

Response to Novelty and its Rapid Habituation in Locus Coeruleus Neurons of the Freely Exploring Rat

Vankov, A., Hervé‐Minvielle, A., & Sara, S. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01108.x · Cited by 309 · see citing works

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Kjaerby, C., Andersen, M., Hauglund, N., Untiet, V., Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, P., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01102-9 · Cited by 306 · see citing works

Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks

Charney, D. S., Woods, S. W., Goodman, W. K., & Heninger, G. R. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.8.1030 · Cited by 301 · see citing works

Phasic norepinephrine: A neural interrupt signal for unexpected events

Dayan, P., & Yu, A. J. (2006) · Network Computation in Neural Systems · doi:10.1080/09548980601004024 · Cited by 302 · see citing works

Abnormal Regulation of Noradrenergic Function in Panic Disorders

Charney, D. S. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800110028005 · Cited by 300 · see citing works

The Locus Coeruleus as a Site for Integrating Corticotropin‐Releasing Factor and Noradrenergic Mediation of Stress Responsesa

Valentino, R. J., Foote, S. L., & Page, M. E. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49931.x · Cited by 292 · see citing works

Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat

Shipley, M. T., Halloran, F. J., & de la Torre, J. (1985) · Brain Research · doi:10.1016/0006-8993(85)90537-2 · Cited by 292 · see citing works

Repetition and Event-related Potentials: Distinguishing Early and Late Processes in Affective Picture Perception

Codispoti, M., Ferrari, V., & Bradley, M. M. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.4.577 · Cited by 288 · see citing works

Differential c-Fos Expression in Cholinergic, Monoaminergic, and GABAergic Cell Groups of the Pontomesencephalic Tegmentum after Paradoxical Sleep Deprivation and Recovery

Maloney, K. J., Mainville, L., & Jones, B. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03057.1999 · Cited by 284 · see citing works

Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion

Lee, A. M., Hoy, J. L., Bonci, A., Wilbrecht, L., Stryker, M. P., & Niell, C. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.031 · Cited by 282 · see citing works

Sleep Neurobiology from a Clinical Perspective

España, R. A., & Scammell, T. E. (2011) · SLEEP · doi:10.5665/sleep.1112 · Cited by 282 · see citing works

Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus

Cirelli, C., Pompeiano, M., & Tononi, G. (1996) · Science · doi:10.1126/science.274.5290.1211 · Cited by 270 · see citing works

Locus coeruleus: From global projection system to adaptive regulation of behavior

Aston‐Jones, G., & Waterhouse, B. D. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.001 · Cited by 268 · see citing works

Pka mediates the effects of monoamine transmitters on the K+ current underlying the slow spike frequency adaptation in hippocampal neurons

Pedarzani, P., & Storm, J. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90216-e · Cited by 272 · see citing works

Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S‐expressing neurons in the rat brain

Xu, Y., Gall, C. M., Jackson, V. R., Civelli, O., & Reinscheid, R. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21159 · Cited by 271 · see citing works

Sex Differences in the Locus Coeruleus-Norepinephrine System and its Regulation by Stress

Bangasser, D., Wiersielis, K. R., & Khantsis, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.021 · Cited by 246 · see citing works

Timing is not everything: neuromodulation opens the STDP gate

Pawlak, V. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00146 · Cited by 254 · see citing works

Neuronal Basis of Behavioral State Control

Hobson, J. A., & Steriade, M. (1986) · Comprehensive physiology · doi:10.1002/cphy.cp010414 · Cited by 256 · see citing works

Chapter 23 Role of the locus coeruleus in emotional activation

Aston‐Jones, G., Rajkowski, J., Kubiak, P., Valentino, R. J., & Shipley, M. T. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61877-4 · Cited by 256 · see citing works

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

Hayat, H., Regev, N., Matosevich, N., Sales, A. C., Paredes-Rodriguez, E., Krom, A. J., Bergman, L., Li, Y., Lavigne, M., Kremer, E. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz4232 · Cited by 255 · see citing works

Locus coeruleus neuronal activity during the sleep-waking cycle in mice

Takahashi, K., Kayama, Y., Lin, J., & Sakai, K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.009 · Cited by 251 · see citing works

A locus coeruleus-norepinephrine account of individual differences in working memory capacity and attention control

Nash Unsworth, A., & Robison, M. K. (2017) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1220-5 · Cited by 255 · see citing works

Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor

Valentino, R. J., Page, M. E., & Curtis, A. L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90855-p · Cited by 246 · see citing works

REM sleep and depression: common neurobiological control mechanisms

McCarley, R. W. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.5.565 · Cited by 246 · see citing works

Responses of primate locus coeruleus neurons to simple and complex sensory stimuli

Grant, S. J., Aston‐Jones, G., & Redmond, D. E. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90152-9 · Cited by 170 · see citing works

Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli

Aston-Jones, G., & Bloom, F. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,033 · see citing works

Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task

Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04467.1994 · Cited by 637 · see citing works

ACTIVITY OF NOREPINEPHRINE-CONTAINING LOCUS COERULEUS NEURONS IN THE UNANESTHETIZED SQUIRREL MONKEY

Foote, S., & Bloom, F. (1979) · Elsevier eBooks · doi:10.1016/b978-1-4832-8363-0.50190-7 · Cited by 56 · see citing works

Locus coeruleus neurons in the neonatal rat: Electrical activity and responses to sensory stimulation

Kimura, F., & Nakamura, S. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90055-0 · Cited by 49 · see citing works