Additive wake-promoting actions of medial basal forebrain noradrenergic α1- and β-receptor stimulation.
Abstract
The locus coeruleus-noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states, in part through the actions of noradrenergic beta-receptors in the medial septal (MS) and medial preoptic (MPOA) areas. MPOA alpha1-receptors exert similar wake-promoting actions. The current study examines the influence of alpha1-receptors located within MS on sleep-wake state. In addition, the extent to which alpha1- and beta-receptors located within MS and MPOA interact in the modulation of behavioral state was investigated by examining the effects of individual or combined infusion of alpha1- and beta-agonists into these regions. Results show that alpha1-receptors located within MS exert wake-promoting actions. Within both MS and MPOA, additive wake-promoting actions were observed with alpha1- and beta-receptor stimulation, the sum of which contributes to the overall arousal state of the animal.
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The sedative effects of guanfacine may arise from a variety of actions, including stimulation of presynaptic α2A-receptors on noradrenergic cell bodies and terminals as well as postsynaptic α2B-receptors in the thalamus.
“The sedative effects of guanfacine may arise from a variety of actions, including stimulation of presynaptic α2A-receptors on noradrenergic cell bodies and terminals as well as postsynaptic α2B-receptors in the thalamus (Berridge et al., 2003; McCormick et al., 1991).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Berridge et al., 2003
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Self-citation
- Authors
- Berridge, C. W., Isaac, S. O., & España, R. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Behavioral Neuroscience
- Published
- 2003
- Volume
- 117
- Issue
- 2
- Pages
- 350-359
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2059549940
- Cited by
- 69
- References
- 36
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32MH18931, T32MH018931)
- National Institute on Drug Abuse (DA 00389, R01DA010681, DA-10681)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- noradrenergic receptors, alpha1-adrenoceptors, beta-adrenergic receptors, locus coeruleus, medial septum, medial preoptic area, wakefulness, sleep-wake states, arousal, additive effects
- MeSH terms
- Adrenergic alpha-Agonists, Adrenergic beta-Agonists, Animals, Circadian Rhythm, Dose-Response Relationship, Drug, Electroencephalography, Electromyography, Isoproterenol, Male, Medial Forebrain Bundle, Phenylephrine, Preoptic Area, Receptors, Adrenergic, beta, Septal Nuclei, Sleep, REM, Wakefulness, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha-1, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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