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Cognitive and behavioral therapies in the treatment of insomnia: A meta-analysis
Open accessAbstract
Insomnia is a major public health problem considering its high prevalence, impact on daily life, co-morbidity with other disorders and societal costs. Cognitive behavioral treatment for insomnia (CBTI) is currently considered to be the preferred treatment. However, no meta-analysis exists of all studies using at least one component of CBTI for insomnia, which also uses modern techniques to pool data and to analyze subgroups of patients. We included 87 randomized controlled trials, comparing 118 treatments (3724 patients) to non-treated controls (2579 patients). Overall, the interventions had significant effects on: insomnia severity index (g = 0.98), sleep efficiency (g = 0.71), Pittsburgh sleep quality index (g = 0.65), wake after sleep onset (g = 0.63) and sleep onset latency (SOL; g = 0.57), number of awakenings (g = 0.29) and sleep quality (g = 0.40). The smallest effect was on total sleep time (g = 0.16). Face-to-face treatments of at least four sessions seem to be more effective than self-help interventions or face-to-face interventions with fewer sessions. Otherwise the results seem to be quite robust (similar for patients with or without comorbid disease, younger or older patients, using or not using sleep medication). We conclude that CBTI, either its components or the full package, is effective in the treatment of insomnia.
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Self-citationImpact of Adherence to Digital Cognitive Behavioral Therapy for Insomnia Effectiveness
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Insomnia management in Dutch general practice: a routine care database study
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Pape, L. M., Antypa, N., Spinhoven, P., van Straten, A., Struijs, S. Y., Struijs, S., Garnefski, N., Kraaij, V., Salemink, E., Hurks, P. P. M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-04891-8 · Cited by 6
“They are effective in reducing insomnia in the adult population 11,12 .”
Self-citationAdjunctive smart ring monitoring during digital cognitive behavioral therapy for insomnia
Moon, D. U., Lee, Y., Lütt, A., Lee, S., & Lee, E. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-24312-0 · Cited by 4
Pape, L. M., van Straten, A., Struijs, S. Y., Karch, J. D., Spinhoven, P., & Antypa, N. (2025) · SLEEP · doi:10.1093/sleep/zsaf357 · Cited by 8
“Studies on students usually report lower between-group effect sizes than those on the general population, where between-group effect sizes on insomnia severity and related outcomes reach d =0.8 or above [18, 19, 52–56].”
InfluentialSelf-citationHuang, F. F.-Y., & Liu, H.-T. (2023) · Behavioral Sciences · doi:10.3390/bs13100867 · Cited by 6
“Pandemic-induced life interruptions, including telecommuting and lockdowns, have also been causes of insomnia [68].”
BackgroundMaity, A., Wang, A. W., Dreier, M. J., Wallace, V., Orchard, F., Schleider, J. L., Loades, M. E., & Hamilton, J. L. (2023) · Clinical Child Psychology and Psychiatry · doi:10.1177/13591045231205475 · Cited by 8
Armitage, B. T., POTTS, H. W. W., Irwin, M. R., & Fisher, A. (2024) · JMIR Formative Research · doi:10.2196/39554 · Cited by 4
Jung, S., Takeuchi, T., Kitahara, M., Tsutsumi, A., & Nomura, K. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.05.020 · Cited by 7
Fonseca, L. M., Finlay, M., Chaytor, N. S., Morimoto, N. G., Buchwald, D., Dongen, H. P. A. V., Quan, S. F., & Suchy‐Dicey, A. M. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1346807 · Cited by 5
“Sleep disorders may be a modifiable risk factor for physical and mental health concerns later in life, including dementia (van Straten et al., 2018; Blackman et al., 2021).”
BackgroundJansson‐Fröjmark, M., Sunnhed, R., Carney, C. E., & Rosendahl, I. K. (2024) · Behavioral Sleep Medicine · doi:10.1080/15402002.2024.2374264 · Cited by 5
“Relevant research could, for example, clarify the influences of negative thought processes on insomnia symptoms and their potential role as mediators and moderators of cognitive behavioral therapy for insomnia (van Straten et al., 2018).”
Psychological Interventions for Insomnia in Patients with Cancer: A Scoping Review
Gonzalez, A. A., Jimenez-Torres, G. J., de Moraes, A. R., Geng, Y., Pawate, V., Khan, R., Narayanan, S., & Yennurajalingam, S. (2024) · Cancers · doi:10.3390/cancers16223850 · Cited by 6
“Sleep health has been described as a complex and multidimensional pattern of sleep and wakefulness that is tailored to individual, social, and environmental needs, supporting both physical and mental well-being [29].”
Personalized sleep-aiding music intervention for insomnia: A closed-loop neurofeedback approach
Li, J., Zhou, M., Zhang, J., Zhang, J., Zhang, L., Zeng, X., & Zhang, H. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106693 · Cited by 6
Li, J., Li, A., Jiao, J., Hu, K., Jiang, Y., Hu, X., Wang, K., Chen, X., & Xie, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-09304-4 · Cited by 5
“As for CBT, which side effects are small, its effectiveness depends on a patient’s willingness to comply 7 ; its efficacy 8 , durability 9 , and cost limits its application.”
Kakazu, V. A., Assis, M., Bacelar, A., Bezerra, A. G., Ciutti, G. L. R., Conway, S. G., Galduróz, J. C. F., Drager, L. F., Khoury, M. P., Leite, I. P. A., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1600767 · Cited by 5
“A few systematic review have performed analyses inferring that in-person CBT-I (either face-to-face or through telehealth) is more effective than dCBT-I (18, 27, 29, 33).”
Negotiation in Automated E-Coaching
Beun, R. J., Griffioen-Both, F., & Lancee, J. (2018) · Electronic workshops in computing · doi:10.14236/ewic/hci2018.24 · Cited by 5
Self-citationCognitive Behavioural Therapy in Children and Adolescents
Suganya, M., Prabakar, S., & Rao, U. M. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00222 · Cited by 7
Weightman, M., Robinson, B., Fallows, R., Henry, A. L., Kyle, S. D., Garratt, E., Pick, A., Teal, R., Ajina, S., Demeyere, N., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-071764 · Cited by 8
Feasibility of a Self-Administered Hypnosis Intervention for Improving Sleep in College Students
Snyder, M., Alldredge, C. T., Stork, S. R., & Elkins, G. R. (2023) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2023.2249047 · Cited by 7
“Limitations of CBT-I include suboptimal compliance with CBT-I protocols and a shortage of therapists trained in CBT-I (Van Straten et al., 2018).”
InfluentialAlldredge, C. T., Snyder, M., Stork, S. R., & Elkins, G. R. (2023) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2023.2278720 · Cited by 7
Reality and perception: Activity monitoring and data collection within a real-world smart home
Fallmann, S., Psychoula, I., Chen, L., Chen, F., Doyle, J., & Triboan, D. (2017) · IEEE SmartWorld, Ubiquitous Intelligence & Computing, Advanced & Trusted Computing, Scalable Computing & Communications, Cloud & Big Data Computing, Internet of People and Smart City Innovation (SmartWorld/SCALCOM/UIC/ATC/CBDCom/IOP/SCI) · doi:10.1109/uic-atc.2017.8397533 · Cited by 5
“i Sleep hygiene is used as treatment for insomnia [13], [16] which includes”
Efficacy of Multicomponent CBT‐I and Its Single Components
Maurer, L., & Kyle, S. D. (2022) · Wiley eBooks · doi:10.1002/9781119891192.ch3 · Cited by 7
Hellrigel-Holderbaum, M., Romanczuk-Seiferth, N., Glos, M., & Fietze, I. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.03.022 · Cited by 5
Maurer, L., Aust, F., & Lorenz, N. (2025) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-025-00502-w · Cited by 4
Xu, D., Li, Z., Leitner, U., & Sun, J. (2024) · Cognitive Therapy and Research · doi:10.1007/s10608-023-10458-6 · Cited by 5
“Previously published meta-analysis studies have concluded that CBT-I has a significant effect in treating insomnia (Seyffert et al., 2016; Straten et al., 2018; Trauer et al., 2015; Zacha-riae et al., 2016; Zweerde et al., 2019a).”
Muhetaer, H., Li, H., Wang, B., Cai, X., Zhang, Y., Li, Y., Li, C., & Wu, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041726 · Cited by 6
Redefining insomnia: from neural dysregulation to personalized therapeutics
Arias-Carrión, Ó. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2564709 · Cited by 5
“Standardized effect size [191,192].”
Faulkner, S., Drake, R., Ogden, M., Gardani, M., & Bee, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269453 · Cited by 7
“There is clear evidence that cognitive behavioural therapy for insomnia (CBTi) can be effective in people with insomnia with and without comorbidity [21–24], and should be used in preference of drug treatments for sleep because of its lower adverse effects [25, 26].”
Management of Sleep and Fatigue in Gastrointestinal Patients
Salwen‐Deremer, J. K., & Sun, M. (2022) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2022.07.007 · Cited by 4
Metadata
- Authors
- van Straten, A., van der Zweerde, T., Kleiboer, A., Cuijpers, P., Morin, C. M., & Lancee, J.
- Affiliations
- Amsterdam Public Health (NL)
- Université Laval (CA)
- University of Amsterdam (NL)
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 38
- Pages
- 3-16
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2587695521
- Semantic Scholar
- 6c1b6f5159447dbff310c8cee6eabea911bf3c07
- Cited by
- 676
- References
- 158
- Citations by year
- 2026: 55 · 2025: 100 · 2024: 90 · 2023: 79 · 2022: 79 · 2021: 77 · 2020: 89 · 2019: 58 · 2018: 34
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- insomnia, cognitive behavioral therapy for insomnia, sleep efficiency, sleep quality, sleep latency, wake after sleep onset, number of awakenings, total sleep time, self-help intervention, number of treatment sessions, comorbid diseases, sleep medication use
- MeSH terms
- Humans, Sleep Initiation and Maintenance Disorders, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic
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