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Cognitive behavioral therapy for insomnia: A meta-analysis of long-term effects in controlled studies
Open accessAbstract
Cognitive behavioral therapy for insomnia (CBT-I) is a treatment with moderate to large effects. These effects are believed to be sustained long-term, but no systematic meta-analyses of recent evidence exist. In this present meta-analysis, we investigate long-term effects in 30 randomized controlled trials (RCTs) comparing CBT-I to non-active control groups. The primary analyses (n = 29 after excluding one study which was an outlier) showed that CBT-I is effective at 3-, 6- and 12-mo compared to non-active controls: Hedges g for Insomnia severity index: 0.64 (3 m), 0.40 (6 m) and 0.25 (12 m); sleep onset latency: 0.38 (3 m), 0.29 (6 m) and 0.40 (12 m); sleep efficiency: 0.51 (3 m), 0.32 (6 m) and 0.35 (12 m). We demonstrate that although effects decline over time, CBT-I produces clinically significant effects that last up to a year after therapy.
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“Those that did report longer follow-ups generally found smaller effects (although still statistically significant), most likely due to the diminishing effects of interventions on sleep quality over time [91].”
From Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials (2021) · cites this paper as [91]
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“Treatment for sleep difficulties CBT for insomnia (CBT-I) is considered a frontline treatment for sleep difficulties [4, 248, 286, 291].”
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“A meta-analysis conducted in 2019 con fi rmed the sustained effectiveness of CBT-I at three, six, and twelve months compared to no treatment; however, the clinical bene fi ts in the active treatment group appear to diminish over time (15).”
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“Effect sizes in these studies were consistent with benchmark estimates reported in meta-analyses of full or abbreviated CBT-I (Kwon et al. 2022; van der Zweerde et al. 2019).”
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“Although cognitive behavioral therapy (CBT) is the fi rst-line treatment for chronic insomnia, an impediment to its wider utilization is the lack of suitably trained psychologists (6).”
CBT-I for people who failed CBT-I
Grandner, M. A., Esquivel, D. R., & Dawson, S. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822872-2.00020-7 · Cited by 4
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Digital Health Interventions for Insomnia: Turning Promise into Reality
Kutana, S., Garland, S. N., & Zhou, E. S. (2023) · Current Sleep Medicine Reports · doi:10.1007/s40675-023-00260-x · Cited by 4
Moulder, Z., Sweetman, A., Lovato, N., Micic, G., Lack, L. C., & Scott, H. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14142 · Cited by 6
“The chronic disorder affects about 6% – 13% of the general population (Deloitte Access Economics, 2017; Harvey & Tang, 2012; van der Zweerde et al., 2019).”
Jun, J., Park, C. G., Fritschi, C., Izci‐Balserak, B., Martyn-Nemeth, P. A., Kuna, S. T., & Kapella, M. C. (2023) · Heart & Lung · doi:10.1016/j.hrtlng.2023.11.001 · Cited by 3
Pape, L. M., Jonker, S., Kivelä, L. M. M., van Straten, A., & Antypa, N. (2024) · BMC Psychology · doi:10.1186/s40359-024-02057-1 · Cited by 3
Christensen, K. A., Bottera, A. R., Forbush, K. T., Isquith, J., & Young, K. P. D. (2025) · International Journal of Eating Disorders · doi:10.1002/eat.24540 · Cited by 4
“Critically, participants had already completed a course of ED treatment prior to BBTI, which may have limited the opportunity to observe further improvements in some ED outcomes.”
Salwen‐Deremer, J. K., Westvold, S. J., Aschbrenner, K. A., Smith, M. T., & Siegel, C. A. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf210 · Cited by 3
Heun‐Johnson, H., Thunell, J. A., Cloughesy, J. N., Linder, J. A., Persell, S. D., Sullivan, M. D., Tysinger, B., & Doctor, J. N. (2025) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2025.101284 · Cited by 4
Stern, É., DAHAN, L., Maruani, J., Palagini, L., Dufayet, G., Lengereau, A., Lejoyeux, M., Bungener, C., & Geoffroy, P. A. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117058 · Cited by 3
Treatment of insomnia disorder in psychiatry: A practical guide for CBT-I based intervention
Stern, É., Poirot, I., Brion, A., Dufayet, G., Maruani, J., & Geoffroy, P. A. (2026) · L Encéphale · doi:10.1016/j.encep.2026.02.009 · Cited by 3
Fiori, V., Lombardo, C., Baglioni, C., & Ballesio, A. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102339 · Cited by 3
Ren, R., Zhang, Y., Shi, Y., Zhang, H., Vitiello, M. V., & Tang, X. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.03.012 · Cited by 3
Choukas, N. R., Woodworth, E. C., Manglani, H. R., Greenberg, J., & Mace, R. A. (2024) · Behavioral Sleep Medicine · doi:10.1080/15402002.2024.2401457 · Cited by 3
“…term (Mitchell et al., 2012; Rios et al., 2019; Smith et al., 2002), has durable treatment effects (Okajima et al., 2011; Pallesen et al., 1998; van der Zweerde et al., 2019), and is recognized as the first-line treatment for insomnia disorder by the American College of Physicians (Edinger et…”
Green, S. M., Furtado, M., Shea, A. K., Ballantyne, E. C., Streiner, D. L., Frey, B. N., & McCabe, R. E. (2025) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdaf085 · Cited by 3
Lemelin, A., Savard, J., Chen, M., Shepherd, L. E., Burnell, M. J., Levine, M., Chen, B. E., & Lemieux, J. (2025) · Cancers · doi:10.3390/cancers17111838 · Cited by 3
“Its efficacy in treating cancer-related insomnia is well-established [42,43].”
Rauwerda, N. L., Knoop, H., Pot, I., van Straten, A., Rikkert, M., Zondervan, A., Timmerhuis, T. P. J., Braamse, A. M. J., & Boss, H. M. (2021) · Trials · doi:10.1186/s13063-021-05868-4 · Cited by 3
“Third, there remains a proportion of individuals in which insomnia does not respond to (approximately 20%) or remits (40%) after CBT-I treatment [20].”
BackgroundTreatment of Insomnia within an Interdisciplinary Pain Rehabilitation Program: A Randomized Trial
Craner, J. R., Flegge, L. G., & Gabelman, R. B. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100295 · Cited by 3
Sun, Q., Dai, Y., Chen, B., Vgontzas, A. N., Basta, M., Tang, X., Zhang, S., & Li, Y. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10130 · Cited by 3
The role of veterans' PTSD symptoms in veteran couples' insomnia
Khalifian, C. E., Titone, M. K., Wooldridge, J. S., Knopp, K. C., Seibert, G. S., Monson, C. M., & Morland, L. A. (2022) · Family Process · doi:10.1111/famp.12835 · Cited by 3
Sleep Disturbances in Type 1 Diabetes and Mitigating Cardiovascular Risk
Irsheed, G. A., Martyn-Nemeth, P. A., Baron, K. G., & Reutrakul, S. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae539 · Cited by 4
Chen, Y., Pan, S., Xia, Y. Q., Ren, K., Zhang, L., Mo, Z., Chen, J., Zhang, M., Li, H., Shuai, J., et al. (2024) · IEEE Conference on Cybernetics and Intelligent Systems · doi:10.1109/cis-ram61939.2024.10673360 · Cited by 3
“Notably, these benefits were sustained over a long period [6].”
BackgroundInsomnia disorder update: the benefits of screening and treatment for this common presentation
Ree, M. J., & Richardson, C. E. (2021) · Internal Medicine Journal · doi:10.1111/imj.15567 · Cited by 3
Weir (2020) · The Journal of Family Practice · doi:10.12788/jfp.0068 · Cited by 3
Metadata
- Authors
- van der Zweerde, T., Bisdounis, L., Kyle, S. D., Lancee, J., & van Straten, A.
- Affiliations
- University of Amsterdam (NL)
- University of Oxford (GB)
- PsyQ (NL)
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 48
- Pages
- 101208
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2967986432
- Cited by
- 336
- References
- 79
- Citations by year
- 2026: 50 · 2025: 56 · 2024: 50 · 2023: 59 · 2022: 56 · 2021: 36 · 2020: 27 · 2019: 2
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institute for Health Research
- Manchester Biomedical Research Centre
- NIHR Oxford Biomedical Research Centre
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- cognitive behavioral therapy for insomnia, insomnia, long-term treatment outcomes, treatment durability, sleep latency, sleep efficiency, Insomnia Severity Index
- MeSH terms
- Humans, Sleep Initiation and Maintenance Disorders, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic
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