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Simultaneous detection of glucose, uric acid and cholesterol using flexible microneedle electrode array-based biosensor and multi-channel portable electrochemical analyzer
Abstract
Abstract The development of versatile and low-cost biosensor system for rapid and simultaneous detection of multiple blood metabolites is highly demanded for home healthcare. We developed a flexible microneedle electrode array-based biosensor (MEAB) and a multi-channel portable electrochemical analyzer (MPEA) for the simultaneous detection of glucose, uric acid, and cholesterol. Microneedle electrode array (MEA) was fabricated on the flexible substrate using magnetorheological drawing lithography, followed by sputter coated with Au/Ti film. Then, through biofunctionalized with glucose oxidase, uricase and cholesterol oxidase, MEA was conditioned as a biosensor for simultaneous detection of glucose, uric acid and cholesterol. MEAB demonstrated excellent sensing performance with a wide linear range (glucose, 2–12 mM; uric acid, 0.1–1.2 mM; cholesterol, 1–12 mM), low detection limit (glucose, 260 μM; uric acid, 4 μM; cholesterol, 440 μM), and rapid response time (∼4 s). MPEA, a homemade ARM STM32 microcontroller-based electrochemical analyzer, was validated to be comparable to that of the commercial electrochemical workstation. MPEA integrated with flexible MEAB could accurately and simultaneously detect glucose, uric acid, and cholesterol levels in serum, and the results were consistent with the portable electrochemical device. The ease-of-use of the reported biosensor system will facilitate effective monitoring of blood metabolites at home.
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Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Gao, W., Emaminejad, S., Nyein, H. Y. Y., Challa, S., Chen, K., Peck, A., Fahad, H. M., Ota, H., Shiraki, H., Kiriya, D., et al. (2016) · Nature · doi:10.1038/nature16521 · Cited by 5,087
Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics
Kim, J., Imani, S., de Araujo, W. R., Warchall, J., Valdés-Ramírez, G., Paixão, T. R. L. C., Mercier, P. P., & Wang, J. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.07.039 · Cited by 678
Cited by
Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review
Saha, T., Del Caño, R., Mahato, K., De la Paz, E., Chen, C., Ding, S., Yin, L., & Wang, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00078 · Cited by 442
Lab under the Skin: Microneedle Based Wearable Devices
Teymourian, H., Tehrani, F., Mahato, K., & Wang, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002255 · Cited by 310
Cheng, S., Gu, Z., Zhou, L., Hao, M., An, H., Song, K., Wu, X., Zhang, K., Zhao, Z., Dong, Y., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.765987 · Cited by 64
Jiang, L., Wang, L., Zhan, D.-S., Jiang, W.-R., Fodjo, E. K., Hafez, M. E., Zhang, Y.-M., Zhao, H., Qian, R.-C., & Li, D.-W. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112918 · Cited by 41
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Metadata
- Authors
- Gao, J., Huang, W., Chen, Z., Yi, C., & Jiang, L.
- Venue
- Sensors and Actuators B: Chemical
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 287
- Pages
- 102-110
- ISSN
- 0925-4005 (ISSN-L)
- OpenAlex
- W2914139830
- Cited by
- 215
- References
- 2
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gao, J., Huang, W., Chen, Z., Yi, C., & Jiang, L. (2019). Simultaneous detection of glucose, uric acid and cholesterol using flexible microneedle electrode array-based biosensor and multi-channel portable electrochemical analyzer. Sensors and Actuators B: Chemical. https://doi.org/10.1016/j.snb.2019.02.020
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