Electrochemically renewable SERS sensor: A new platform for the detection of metabolites involved in peroxide production
Abstract
The accurate detection of hydrogen peroxide (H 2 O 2)-involved metabolites plays a significant role in the early diagnosis of metabolism-associated diseases, whereas most of current metabolite-sensing systems are often hindered by low sensitivity, interference of coexisting species, or tedious preparation. Herein, an electrochemistry-regenerated surface-enhanced Raman scattering (SERS) sensor was developed to serve as a universal platform for detecting H 2 O 2-involved metabolites. The SERS sensor was constructed by modifying newly synthesized 2-mercaptohydroquinone (2-MHQ) molecules on the surface of gold nanoparticles (AuNPs) that were electrochemically predeposited on an ITO electrode. Metabolites were detected through the changes in the SERS spectrum as a result of the reaction of 2-MHQ with H 2 O 2 induced by the metabolites. Combining the superiority of SERS fingerprint identification and the specificity of the related enzymatic reactions producing H 2 O 2, the designed SERS sensor was highly selective in detecting glucose and uric acid as models of H 2 O 2-involved metabolite with limits of detection (LODs) of 0.159 μM and 0.0857 μM, respectively. Moreover, the sensor maintained a high SERS activity even after more than 10 electrochemical regenerations within 2 min, demonstrating its effectiveness for the rapid detection of various metabolites with electrochemistry-driven regulation. Importantly, the presented SERS sensor showed considerable practicability for the detection of metabolites in real serum samples. Accordingly, the SERS sensor is a new detection platform for H 2 O 2-involved metabolites detection in biological fluids, which may aid the early diagnosis of metabolism-related diseases.
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2-MHQ immobilized on AuNRs reacts with H2O2, oxidizing its hydroxyl group to a carbonyl group to form 2-mercaptobenzoquinone (2-MBQ), causing SERS spectral changes.
“The reaction mechanism of 2-MHQ with H2O2 is shown in Figure 2 A, where the hydroxyl group ( ─ OH) of 2-MHQ is oxidized into carbonyl group ( ═ O), resulting in the formation of 2-mercaptobenzoquinone (2-MBQ) and the changes of SERS spectra when the oxidant H2O2 exists. [30,31]”
From Multiplex Cellular Microenvironment Detection Based on Surface-Enhanced Raman Scattering Patch (2025) · cites this paper as [30]
The Raman characteristic peak at 482 cm−1 of 2-MHQ is unsusceptible to H2O2 and serves as the intrinsic internal standard for spectra normalization.
“The Raman characteristic peak at 482 cm 1 of 2-MHQ is reported unsusceptible to H 2 O2, [30] so it serves as the intrinsic internal standard for spectra normalization.”
From Multiplex Cellular Microenvironment Detection Based on Surface-Enhanced Raman Scattering Patch (2025) · cites this paper as [30]
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- Authors
- Jiang, L., Wang, L., Zhan, D.-S., Jiang, W.-R., Fodjo, E. K., Hafez, M. E., Zhang, Y.-M., Zhao, H., Qian, R.-C., & Li, D.-W.
- Affiliations
- East China University of Science and Technology (CN)
- Fudan University (CN)
- Corresponding author
- Qian, Ruo-Can
- Li, Da-Wei
- ORCID
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 175
- Pages
- 112918
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W3114952407
- Cited by
- 41
- References
- 53
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 5
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities
- Science and Technology Commission of Shanghai Municipality
- National Natural Science Foundation of China
- National Major Science and Technology Projects of China
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- surface-enhanced Raman scattering, hydrogen peroxide, gold nanoparticles, glucose detection, uric acid detection, SERS spectroscopy, electrochemical regeneration
- MeSH terms
- Gold, Hydrogen Peroxide, Peroxides, Spectrum Analysis, Raman, Biosensing Techniques, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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