The DOI matches its Crossref record; 89 of the 91 references it cites were found in a registry or an index.
Brain Iron Metabolism
Abstract
Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin. Transferrin synthesized by oligodendrocytes in the brain binds much of the iron that traverses the blood-brain barrier after oxidation of the iron, most likely by a glycophosphosinositide-linked ceruloplasmin found in astrocytic foot processes that ensheathe brain endothelial cells. Neurons acquire iron from diferric transferrin, but it is less clear how glial cells acquire iron. In aging mammals, iron accumulates in the basal ganglia, and iron accumulation is believed to contribute to neurodegenerative diseases, including Parkinson and Alzheimer disease. Here we consider the possibility that iron accumulations, which are often thought to facilitate free radical generation and oxidative damage, may contain insoluble iron that is unavailable for cellular use, and the pathology associated with iron accumulations may result from functional iron deficiency in some diseases.
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“The cytosolic iron pool is highly regulated because it is an important source of iron for numerous cytosolic and nuclear iron proteins, as well as being a source from which mitochondria and other organelles derive iron (Rouault and Cooperman, 2006).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Rouault and Cooperman, 2006
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Cites
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
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Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Iron, brain ageing and neurodegenerative disorders
Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801
Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267
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Cuprizone Administration Alters the Iron Metabolism in the Mouse Model of Multiple Sclerosis
Varga, E., Pandur, E., Abrahám, H., Horváth, A., Ács, P., Komoly, S., Miseta, A., & Sipos, K. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0578-5 · Cited by 27
Iron, Oxidative Stress and Health
Udipi, S., Ghugre, P., & Gokhale, C. (2012) · Oxidative Stress - Molecular Mechanisms and Biological Effects · doi:10.5772/34975 · Cited by 17
“(b) Cellular homeostasis: The cytosolic iron pool is highly regulated because it is an important source of iron for numerous cytosolic and nuclear iron proteins, as well as being a source from which mitochondria and other organelles derive iron (Rouault and Cooperman, 2006).”
Background
Metadata
- Authors
- Rouault, T. A., & Cooperman, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Rouault, Tracey A.
- ORCID
- Rouault, Tracey A.
- Venue
- Seminars in Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 13
- Issue
- 3
- Pages
- 142-148
- ISSN
- 1071-9091 (ISSN-L)
- OpenAlex
- W2049888915
- Cited by
- 280
- References
- 91
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 8 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 7 · 2019: 9 · 2018: 13 · 2017: 16 · 2016: 12 · 2015: 13 · 2014: 18 · 2013: 23 · 2012: 19
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- brain iron metabolism, blood-brain barrier, transferrin receptor 1, brain endothelial cells, ferroportin, transferrin, oligodendrocytes, ceruloplasmin, astrocytes, iron accumulation, basal ganglia, Parkinson's disease, Alzheimer's disease, neurodegeneration, iron deficiency, oxidative damage, free radicals
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Central Nervous System, Humans, Iron, Nerve Degeneration, Iron Metabolism Disorders
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