Rouault, Tracey A.

Regulating the fate of mRNA: the control of cellular iron metabolism

Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell

Iron Metabolism and DisordersRNA Research and Splicing

Cited by 1,210

The role of iron regulatory proteins in mammalian iron homeostasis and disease

Rouault, T. A. (2006) · Nature Chemical Biology

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 1,055

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 709

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

Wang, R.-H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) · Cell Metabolism

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 614

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 571

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 509

Iron metabolism in the CNS: implications for neurodegenerative diseases

Rouault, T. A. (2013) · Nature Reviews Neuroscience

Neurological diseases and metabolismIron Metabolism and Disorders

Cited by 496

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

Cohen, L. A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.-L., Crooks, D. R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M. W., et al. (2010) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 452

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

Meyron‐Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre‐Wilson, H., Grinberg, A., Love, P., et al. (2004) · The EMBO Journal

Iron Metabolism and DisordersTrace Elements in Health

Cited by 408

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

Rouault, T. A., Hentze, M. W., Caughman, S. W., Harford, J. B., & Klausner, R. D. (1988) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 351

Iron-dependent regulation of the divalent metal ion transporter

Gunshin, H., Allerson, C. R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J. T., Kishi, F., Hentze, M. W., Rouault, T. A., Andrews, N. C., & Hediger, M. A. (2001) · FEBS Letters

Iron Metabolism and DisordersTrace Elements in Health

Cited by 305

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

Tong, W.-H., & Rouault, T. A. (2006) · Cell Metabolism

Metalloenzymes and iron-sulfur proteinsIron Metabolism and Disorders

Cited by 294

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L., & Rouault, T. A. (1998) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersUbiquitin and proteasome pathways

Cited by 293

A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression

Zhang, D.-L., Hughes, R. M., Ollivierre-Wilson, H., Ghosh, M. C., & Rouault, T. A. (2009) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 281

Brain Iron Metabolism

Rouault, T. A., & Cooperman, S. (2006) · Seminars in Pediatric Neurology

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 280

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

Hentze, M. W., Rouault, T. A., Caughman, S. W., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 249

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

Cooperman, S. S., Meyron-Holtz, E. G., Olivierre-Wilson, H., Ghosh, M. C., McConnell, J. P., & Rouault, T. A. (2005) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 235

Ferritin is secreted via 2 distinct nonclassical vesicular pathways

Truman-Rosentsvit, M., Berenbaum, D., Spektor, L., Cohen, L. A., Belizowsky-Moshe, S., Lifshitz, L., Ma, J., Li, W., Kesselman, E., Abutbul-Ionita, I., et al. (2018) · Blood

Iron Metabolism and DisordersCellular transport and secretion

Cited by 223

The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

Tong, W.-H., Sourbier, C., Kovtunovych, G., Jeong, S. Y., Vira, M., Ghosh, M., Romero, V. V., Sougrat, R., Vaulont, S., Viollet, B., et al. (2011) · Cancer Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 212

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

Iwai, K., Klausner, R. D., & Rouault, T. A. (1995) · The EMBO Journal

Iron Metabolism and DisordersRNA Research and Splicing

Cited by 211

Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier

Wu, L. J.-C., Leenders, A. G. M., Cooperman, S., Meyron-Holtz, E., Smith, S., Land, W., Tsai, R. Y. L., Berger, U. V., Sheng, Z.-H., & Rouault, T. A. (2004) · Brain Research

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 210

Mammalian iron-sulphur proteins: novel insights into biogenesis and function

Rouault, T. A. (2015) · Nature Reviews Molecular Cell Biology

Metalloenzymes and iron-sulfur proteinsMitochondrial Function and Pathology

Cited by 201

Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene☆

Gordeuk, V. R., Caleffi, A., Corradini, E., Ferrara, F., Jones, R. A., Castro, O., Onyekwere, O., Kittles, R., Pignatti, E., Montosi, G., et al. (2003) · Blood Cells, Molecules, and Diseases

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 198

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

Tong, W., & Rouault, T. (2000) · The EMBO Journal

Metalloenzymes and iron-sulfur proteinsMitochondrial Function and Pathology

Cited by 194