Iron, brain ageing and neurodegenerative disorders

Neurodegenerative diseases and oxidative stress

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Neurovascular regulation in the normal brain and in Alzheimer's disease

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A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

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Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

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Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

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Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

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Staging of Alzheimer-Related Cortical Destruction

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I <scp>RON</scp> S <scp>TATUS AND</scp> N <scp>EURAL</scp> F <scp>UNCTIONING</scp>

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Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

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Aceruloplasminemia: molecular characterization of this disorder of iron metabolism.

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Brain iron and ferritin in Parkinson’s and Alzheimer’s diseases

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Iron, Neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

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A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains

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Metal complexing agents as therapies for Alzheimer’s disease

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Ironing Iron Out in Parkinson's Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6‐Hydroxydopamine and Iron Chelators, Desferal and VK‐28

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Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

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Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson?s disease and other neurodegenerative diseases

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Association of <i>HFE</i> mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with <i>APOE</i>

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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Oxidative stress and neurodegeneration: where are we now?

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13 reasons why the brain is susceptible to oxidative stress

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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

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Regulation of cellular iron metabolism

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The Aging Brain

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Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

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Forging a field: the golden age of iron biology.

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

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Alzheimer's disease as homeostatic responses to age-related myelin breakdown

Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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Copper and iron disorders of the brain

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Intracellular iron transport and storage: from molecular mechanisms to health implications

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Iron metabolism in the CNS: implications for neurodegenerative diseases

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Oxidative stress and aberrant signaling in aging and cognitive decline

Dröge, W., & Schipper, H. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00294.x · Cited by 479 · see citing works

Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature

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Current challenges in understanding melanogenesis: Bridging chemistry, biological control, morphology, and function

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

Galaris, D., & Pantopoulos, K. (2008) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701713104 · Cited by 352 · see citing works

Microglial pathology

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Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders

Mills, E., Dong, X.-P., Wang, F., & Xu, H. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.09.140 · Cited by 309 · see citing works

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

Zheng, W., & Monnot, A. D. (2012) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2011.10.006 · Cited by 302 · see citing works

Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring

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Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings

Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.009 · Cited by 293 · see citing works

Brain Iron Metabolism

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Heme scavenging and the other facets of hemopexin

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Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258 · see citing works

Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

Bartzokis, G., Lu, P. H., Tishler, T. A., Fong, S. M., Oluwadara, B., Finn, J. P., Huang, D., Bordelon, Y., Mintz, J., & Perlman, S. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9352-7 · Cited by 238 · see citing works

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

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Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

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In vivo detection of iron and Neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage

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The pivotal role of astrocytes in the metabolism of iron in the brain

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Diverse functional roles of lipocalin-2 in the central nervous system

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A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

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Mitochondrial iron metabolism and its role in neurodegeneration

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Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

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Novel multifunctional neuroprotective iron chelator‐monoamine oxidase inhibitor drugs for neurodegenerative diseases.<i>In vivo</i>selective brain monoamine oxidase inhibition and prevention of MPTP‐induced striatal dopamine depletion

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Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

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Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

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Cortical iron reflects severity of Alzheimer's disease

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Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

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Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives

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Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

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Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

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Three-Dimensional Tomographic Imaging and Characterization of Iron Compounds within Alzheimer's Plaque Core Material

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Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

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Serial Susceptibility Weighted MRI Measures Brain Iron and Microbleeds in Dementia

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Therapeutic targets and potential of the novel brain‐ permeable multifunctional iron chelator–monoamine oxidase inhibitor drug, M‐30, for the treatment of Alzheimer's disease¹

Avramovich‐Tirosh, Y., Amit, T., Bar‐Am, O., Zheng, H., Fridkin, M., & Youdim, M. B. H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04258.x · Cited by 130 · see citing works

Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

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Hepcidin antagonists for potential treatments of disorders with hepcidin excess

Poli, M., Asperti, M., Ruzzenenti, P., Regoni, M., & Arosio, P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00086 · Cited by 124 · see citing works

Iron: A New Target for Pharmacological Intervention in Neurodegenerative Diseases

Whitnall, M., & Richardson, D. R. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.08.008 · Cited by 113 · see citing works

Role of brain iron accumulation in cognitive dysfunction: evidence from animal models and human studies

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Plants-derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms

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Biogenic metallic elements in the human brain?

Everett, J., Lermyte, F., Brooks, J., Tjendana-Tjhin, V., Plascencia-Villa, G., Hands-Portman, I., Donnelly, J. M., Billimoria, K., Perry, G., Zhu, X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf6707 · Cited by 94 · see citing works

Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection

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Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage #

Darshan, D., Vanoaica, L., Richman, L., Beermann, F., & Kühn, L. C. (2009) · Hepatology · doi:10.1002/hep.23058 · Cited by 86 · see citing works

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

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A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys

Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0835-10.2010 · Cited by 85 · see citing works

Senescent Microglia: The Key to the Ageing Brain?

Greenwood, E. K., & Brown, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094402 · Cited by 84 · see citing works

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Belaidi, A. A., Gunn, A. P., Wong, B. X., Ayton, S., Appukuttan, A. T., Roberts, B. R., Duce, J. A., & Bush, A. I. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0656-x · Cited by 83 · see citing works

Fluorescent probes for the detection of catalytic Fe(II) ion

Hirayama, T. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.004 · Cited by 79 · see citing works

Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Hare, D. J., Adlard, P. A., Doble, P. A., & Finkelstein, D. I. (2013) · Metallomics · doi:10.1039/c2mt20164j · Cited by 78 · see citing works

Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation

Hui, Y., Wang, D., Li, W., Zhang, L., Jin, J., Ma, N., Zhou, L., Nakajima, O., Zhao, W., & Gao, X. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102061 · Cited by 71 · see citing works

A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice

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M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson’s disease

Gal, S., Fridkin, M., Amit, T., Zheng, H., & Youdim, M. B. H. (2006) · Parkinson’s Disease and Related Disorders · doi:10.1007/978-3-211-45295-0_68 · Cited by 58 · see citing works

Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons

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Predicting white matter integrity from multiple common genetic variants

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Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide

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Iron Chelation Inhibits NF-κB–Mediated Adhesion Molecule Expression by Inhibiting p22 ^phox Protein Expression and NADPH Oxidase Activity

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The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats

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