Cited by 280Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

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Brain Iron Metabolism

Rouault, Tracey A., Cooperman, Sharon·2006·Seminars in Pediatric Neurology

DOI 10.1016/j.spen.2006.08.002

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Abstract

Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin. Transferrin synthesized by oligodendrocytes in the brain binds much of the iron that traverses the blood-brain barrier after oxidation of the iron, most likely by a glycophosphosinositide-linked ceruloplasmin found in astrocytic foot processes that ensheathe brain endothelial cells. Neurons acquire iron from diferric transferrin, but it is less clear how glial cells acquire iron. In aging mammals, iron accumulates in the basal ganglia, and iron accumulation is believed to contribute to neurodegenerative diseases, including Parkinson and Alzheimer disease. Here we consider the possibility that iron accumulations, which are often thought to facilitate free radical generation and oxidative damage, may contain insoluble iron that is unavailable for cellular use, and the pathology associated with iron accumulations may result from functional iron deficiency in some diseases.

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Authors: Rouault, T. A., & Cooperman, S.
Affiliations: National Institutes of Health (US)
Corresponding author: Rouault, Tracey A.
ORCID: Rouault, Tracey A.
Venue: Seminars in Pediatric Neurology
Publisher: Elsevier BV
Published: 2006-09
Volume: 13
Issue: 3
Pages: 142-148
ISSN: 1071-9091 (ISSN-L)
DOI: 10.1016/j.spen.2006.08.002
OpenAlex: W2049888915
Cited by: 280
References: 91
Citations by year: 2026: 8 · 2025: 10 · 2024: 8 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 7 · 2019: 9 · 2018: 13 · 2017: 16 · 2016: 12 · 2015: 13 · 2014: 18 · 2013: 23 · 2012: 19
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Pediatric Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: brain iron metabolism, blood-brain barrier, transferrin receptor 1, brain endothelial cells, ferroportin, transferrin, oligodendrocytes, ceruloplasmin, astrocytes, iron accumulation, basal ganglia, Parkinson's disease, Alzheimer's disease, neurodegeneration, iron deficiency, oxidative damage, free radicals
MeSH terms: Animals, Blood-Brain Barrier, Brain, Central Nervous System, Humans, Iron, Nerve Degeneration, Iron Metabolism Disorders

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