The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1
Open accessAbstract
Summary The traditional view of hematopoiesis has been that all the cells of the peripheral blood are the progeny of a unitary homogeneous pool of hematopoietic stem cells (HSCs). Recent evidence suggests that the hematopoietic system is actually maintained by a consortium of HSC subtypes with distinct functional characteristics. We show here that myeloid-biased HSCs (My-HSCs) and lymphoid-biased (Ly-HSCs) can be purified according to their capacity for Hoechst dye efflux in combination with canonical HSC markers. These phenotypes are stable under natural (aging) or artificial (serial transplantation) stress and are exacerbated in the presence of competing HSCs. My- and Ly-HSCs respond differently to TGFβ1, presenting a possible mechanism for differential regulation of HSC subtype activation. This study demonstrates definitive isolation of lineage-biased HSC subtypes and contributes to the fundamental change in view that the hematopoietic system is maintained by a continuum of HSC subtypes, rather than a functionally uniform pool.
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Cited by
Dnmt3a is essential for hematopoietic stem cell differentiation
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Metadata
- Authors
- Challen, G. A., Boles, N. C., Chambers, S. M., & Goodell, M. A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 6
- Issue
- 3
- Pages
- 265-278
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1984850507
- Cited by
- 577
- References
- 59
- FWCI
- 26.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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