Cited by 628Neurogenesis and neuroplasticity mechanismsSpinal Cord Injury ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

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Abstract

Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury.

Overview

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Crossref · 10.1016/j.stem.2010.07.014

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Metadata

Authors
Barnabé-Heider, F., Göritz, C., Sabelström, H., Takebayashi, H., Pfrieger, F. W., Meletis, K., & Frisén, J.
Affiliations
  • Karolinska Institutet (SE)
  • Kumamoto University (JP)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Frisén, Jonas
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2010-10
Volume
7
Issue
4
Pages
470-482
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W2128475302
Cited by
628
References
58
Citations by year
2026: 28 · 2025: 33 · 2024: 34 · 2023: 44 · 2022: 40 · 2021: 64 · 2020: 35 · 2019: 37 · 2018: 46 · 2017: 48 · 2016: 42 · 2015: 44 · 2014: 48 · 2013: 33 · 2012: 24
FWCI
8.51
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
adult spinal cord, glial cell origin, spinal cord injury, oligodendrocyte progenitors, astrocytes, ependymal cells, neural stem cells, cell proliferation, self-renewal, genetic fate mapping
MeSH terms
Animals, Immunohistochemistry, Mice, Transgenic, Neuroglia, Spinal Cord Injuries, Stem Cells, Mice, Spinal Cord Regeneration

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